Vasopressin Receptor Signaling and Cycling of Water Channels in Renal Epithelia

摘要

Water reabsorption and urinary volume regulation are important processes inmaintaining normal physiological function and vasopressin (ADH) regulates water reabsorption by the kidney in response to changes in plasma volume as may occur during dehydration. This process is particularly important to soldiers who are subject to excess heat and fluid deprivation in and environments. We have been examining the mechanisms whereby ADH enhances water permeability in renal epithelia so we may find measures to enhance the kidney's responsiveness to ADH. Such regimens would maintain the water reabsorptive capacity of soldiers facing harsh conditions. Our observations suggest that an integral component of the water reabsorptive process by ADH is the cycling of water channels from the