Preclinical Evaluation of a Decision Support Medical Monitoring System for Early Detection of Potential Hemodynamic Decompensation During Blood Loss in Humans.

摘要

The goal of this research is to perform a preclinical evaluation of a non-Invasive medical monitoring device to predict blood loss and hemorrhage in humans . The aim is to be able to detect subtle changes in hemodynamic variables that provide prodromal clues to impending cardiovascular collapse. This will enhance the ability of first responders (medics), nurses , and physicians to intervene with appropriate resuscitative steps in individuals who have suffered injuries during combat. Since the last progress report we have studied a total of 12 subjects . These individuals have been subjected to -15 , -30, and -45 mmHg of lower body negative pressure ( LBNP ) and sequential blood loss of 333 , 666 , and 1 L total. Three abstracts related to this work have been presented and two additional abstracts have been submitted for presentation the high-resolution physiological records have been obtained for subsequent process in g by machine teaming algorithms, and further off-line validation of the cardiovascular reserve index (CRI) approach develop at the US Army Institute of Surgical Research Labs . In general, our preliminary data shows that there is good agreement for a number of physiological (blood pressures. CVP etc .) variables when LBNP is compared to blood loss and also good agreement between human and prior animal data. Nuances of the data are still being analyzed in collaboration with our colleagues at the U .S . Army Institute of Surgical Research.