Staphylococcal Enterotoxin: Role of Intestinal Immunity in Enterotoxin BIntoxication

摘要

The purpose of the study was to investigate the role of intestinal immunity instaphylococcal enterotoxins intoxication. We have chosen the mouse as experimental model, which although resistant to enterotoxins, has a certain advantage by not having an emetic mechanism, thus no loss in peroral administered enterotoxin takes place. Parenteral administration of enterotoxins induced a high titer of specific antibodies in serum, mainly of IgG and IgG2a subclasses. Peroral administration of enterotoxin elicited a good response at the intestinal level as showed by specific anti-enterotoxin antibodies in the supernatants of in vitro cultured intestinal fragments and the synthesized immunoglobulin was IgA. When different routes and combinations of them were studied it was observed that a parenteral followed by peroral administration of enterotoxin induced the higher intestinal immune response. Secretion of specific anti-enterotoxin antibodies by intestinal immune system also lasted longer compared to the presence of antibodies in serum of perorally by immunized animals. Staphylococcus aureus, Enterotoxin B, IgA, Immunity.