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Comparison of the Effects of Hyperbaric Oxygenation and Transforming GrowthFactor Beta on Wound Healing in Rats

机译:高压氧与转化生长因子β对大鼠创面愈合影响的比较

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A pilot investigation was conducted to determine the effects of hyperbaricoxygenation (HBO) and topical transforming growth factor beta (TGF-Beta 1), alone and in combination, on the healing of standardized excisional wounds in normal rats. Excisional wounds were made on the dorsum of 96 adult male Sprague-Dawley rats, and rats were randomly allocated into groups receiving daily topical TGF-Beta 1 or placebo solution. Groups were subdivided into animals treated with either ground level air, 2.0 ATA air, ground level 100% oxygen, or 2.0 ATA 100% oxygen. Each 4 days, wounds were measured, animals weighed, and 2 animals euthanized for histologic study to assess healing. The study found that TGF-Beta I treated rats healed faster, with maximum effect 12 days after wounding. Breathing mix and depth had no significant effect on healing. Animals treated with oxygen gained significantly more weight than animals treated with air. Hyperbaric oxygen, Wound healing, Growth factor, Rat, Oxygen.

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