Natural History of HIV Infection in Filipino Female Commercial Sex Workers

摘要

A prospective follow-up study of the progression of HlV infection, fromseroconversion to onset of opportunistic infections (OI) indicative of immune deficiency and to death, was performed in a cohort of 54 HIV-1 antibody positive Filipino female commercial sex workers (FCSW). The cumulative probability of having a CD4+ T cell count of <200/mm3 and/or an OI indicative of severe immune deficiency was 52.9% within 5 years and 73.8% within 6 years after seroconversion. The cumulative probability of death was B 52.1% within 6.5 years following seroconversion and 52.7% within 1.5 years after a depressed (<200/mm3) CD4 T cell or onset of an 01. Although several OI associated with immune impairment were observed a CD4(+) cell count of <200/mm3 was the initial indicator of a failing immune system in more than 50% of the patients. Mycobacterium tuberculosis or unidentified acid fast bacilli (presumed to be M. tuberculosis) and Pneumocystis carinii pneumonia were the initial indicators of immune deficiency in the remaining patients. pg2. JMD.