Protection Against the Acute and Delayed Toxicities of Mustard and Mustard-LikeCompounds

摘要

We are investigating the hypothesis that modalities which cause a reversible cellcycle arrest will decrease sulfur mustard toxicity by allowing more time for DNA repair before cell division takes place. Both human fibroblasts and NM-1 keratinocytes have been exposed to hypothermic conditions (280C). This temperature arrests the growth of both cell lines, but they recover rapidly on transfer back to 37 deg C. Similarly, exposure to 8 uM ciclopirox olamine produces a readily reversible cell cycle arrest. Experiments are currently in progress to determine the efficacy of these treatments in reducing sulfur mustard cytotoxicity.