Clinical Effects of Organophosphorus Cholinesterase Inhibitors

摘要

Nerve agents, highly toxic organophosphorus cholinesterase inhibitors, inhibitacetyicholinesterase and cause an accumulation of acetyicholine. Clinical effects depend on the route and amount of exposure and include miosis, bronchoconstriction, excessive secretions, vomiting, seizures, and cessation of respiratory and cardiac activity. Eye effects include miosis, engorgement of ocular vessels, pain, and a decrease in light sensitivity. Therapy consists of atropine, a cholinesterase reactivator (pralidoxime), and ventilation as needed.