Comparison of the Efficacy of HI6 and 2-PAM against Soman, Tabun, Sarin, and VXin the Rabbit

摘要

This study compared the efficacy of H16 and 2-PAM against nerve agent (somantabun sarin and VX) -induced lethality in the atropinesterase-free rabbits pretreated with vehicle (controls) or pyridostigmine. Treatment was administered at signs or 2 min after agent challenge and consisted ofoxime (l00umol/lkg) + atropine 13 mg(kg) (alone or together with diazepam). Twenty-four-h LD50 values