B Lymphocyte Immunoglobulin Receptor Desensitization is Downstream of TyrosineKinase Activation. (Reannouncement with New Availability Information)

摘要

Resting mature B cells have two classes of immunoglobulin receptors on theirsurface, IgD and IgM. Activation of a cell by crosslinking one of these receptors leads to homologous and heterologous receptor anergy as judged by the inability to induce a second calcium signal 2 hr after the initial activation step. The mechanism for this anergy is not known. In this report we show that this receptor anergy is downstream of tyrosine kinase activation in that cells pretreated with anti-IgM, when stimulated with anti-IgD, showed tyrosine phosphorylation comparable to that of native cells, but had no calcium response. (Author).