Therapeutic Effects of Defence Against Nerve Agents: An Account of Research atAMRL, 1965-1994

摘要

This document contains an account of research conducted into medical defenceagainst chemical warfare nerve agents at this Laboratory, under its former names of Defence Standards Laboratories, Materials Research Laboratories and Materials Research Laboratory. Most of the work was done between 1965 and 1994, although there is evidence of some activity in this field in the preceding decade. The research was mainly basic studies of the mechanism of action of nerve agents and their antidotes, and into the properties of the biological systems affected by the nerve agents. Research was performed in the fields of neuromuscular pharmacology, cardiac pharmacology and electrophysiology, enzyme kinetics, drug distribution, chromatography, and receptor biochemistry. The achievements of this research are briefly summarised.