Prospective Longitudinal Evaluation of Salivary PAF Levels in Chronic AdultPeriodontitis

摘要

Periodontal diseases, including chronic adult periodontitis, are inflammatory innature. This inflammatory process involves a variety of host cells, cytokines and inflammatory mediators orchestrating events that are usually protective in nature. However, studies examining the relationship of various clinical and biochemical indicators of the destructive periodontal lesion in humans suggest that the host inflammatory response is also involved in the progression of chronic adult periodontitis. Platelet-activating factor (PAF), an extremely potent phospholipid mediator of inflammation, may have a role in the initiation and progression of the active periodontal lesion. In an attempt to gain information on the relevance of PAF in the pathogenesis of chronic adult periodontitis, a longitudinal study examining the relationship of salivary PAF levels and clinical parameters of periodontal disease was undertaken.