Subchronic Toxicity Studies on 1,3,5-Trinitrobenzene, 1,3-Dinitrobenzene, and Tetryl in Rats. 14-Day Toxicity Evaluation of N-Methyl-N, 2,4,6-Tetranitroaniline in Fischer 344 Rats.

摘要

Subacute toxic effects of Tetryl in male and female rats were evaluated by feeding powdered certified laboratory chow diet supplemented with varied concentrations of Tetryl (0, 500, 1250, 2000, 2500 and 5000 mg/kg diet) for fourteen days. The average daily Tetryl doses consumed were 32, 82, 130, 178 and 374 for females and 31, 80, 121, 170 and 350 for males. Food and water consumption were not significantly altered. Final body weight was reduced in only the high dose males while relative organ weights were significantly changed in this same dose group involving the liver (females), kidneys (males), and spleen (males). Hematology and clinical chemistry studies indicated increased values relating to reticulocytes (females) and methemoglobin (females and males) in high and mid dose groups while total protein and albumin were significantly increased in all groups except the 50 mg/kg female group. Alkaline phosphatase was decreased in these same female groups. The only histopathological change noted which was considered meaningful was a mild increase in hyaline droplet deposition in male kidneys in all dose groups. Subacute oral toxicity, Tetryl, Fischer 344 Rats, Clinical chemistry, Hematology, N-Methyl-N, 2.4.6-Tetranitroaniline.