Use of a Porous Implant to Develop an Optimum Method to Examine BoneGrowth/Repair for Biodynamic and Toxicologic Analysis

摘要

Bone repair in experimentally produced defects is regarded as very similar to thehealing of bone after fractures. A cooperative effort within Armstrong Laboratory brought together a combination of resources to accurately assess bone growth and repair. The goal was development of standard procedures for use in determining the effects of biomechanical and toxicological testing. Methods: Simulated bone defects were surgically prepared in twelve rhesus monkeys. These defects were evaluated after one, four, or eight months using histomorphometry and scanning electron microscopy (SEM). Results: Histological evaluation of bone sections showed that bone removed from defect sites had not been replaced. There was no evidence of active bone formation. Conclusion: Healing of bone defects in this group of subjects was not successful under the experimental conditions used. Efforts to determine the reasons for this will not be possible due to new mission guidelines.