Assessment of Skin Penetration of Environmental Contaminants in Air andBioremediated Soil Utilizing the Pig Skin Model

摘要

The percutaneous absorption of carbon-14 labeled trinitrotoluene (TNT) fromvarious media (air, water, acetone and soil) and carbon-14 TNT or its degradation products from compost was determined using excised skin mounted in skin penetration-evaporation chambers. Appearance of label in tissue culture media was used to measure the steady state absorption rate of TNT from saturated air or water. Radiolabel recovered from the dermis and tissue culture media was used to determine percent absorption from acetone, soil and compost. Due to low vapor concentration, the absorption rate of TNT from saturated air was found to be insignificant. The permeability coefficient of TNT from saturated water was used