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Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 3. Results of GeneMutation at the HGPRT Locus in Cultured Chinese Hamster Ovary Cells

机译：1,3,3-三硝基氮杂环丁烷的遗传毒性评价。第3卷。培养的中国仓鼠卵巢细胞中HGpRT基因座的Genemutation结果

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The test substance, 1, 3,3-Trinitroazetidine (TNAZ)both in the presence andabsence of microsomal S-9 liver enzyme, failed to induce a significant increase in mutant colonies at the HGPRT locus in cultured Chinese hamster ovary cells. The effects of TNAZ at the dose levels selected based on the initial range finding assay were similar to those of the negative control (incomplete Ham's F 12 medium) and solvent control (dimethylsulfoxide) substances. Both positive

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Paika, I. J.;
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年度 1994
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总页数 28
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Toxicity; Enzymes; Mutations; Liver; Cells(Biology); Genetics; Ovaries; Test andevaluation; Control; Activation; Methyl radicals; Dosage; Level(Quantity); Solvents; Genes; Range finding; Assaying; Colonies(Biology); Induction systems; Hamsters; China; Loc;

机译：毒性;酶;突变;肝;细胞（生物学）;遗传学;卵巢;测试和评价;对照;活化;甲基;剂量;水平（数量）;溶剂;基因;测距;测定;菌落（生物学）;诱导系统;仓鼠;中国;禄;

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Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 3. Results of GeneMutation at the HGPRT Locus in Cultured Chinese Hamster Ovary Cells

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