Characterization of the Heregulin-Stimulated Activation of the Neu/ErbB2 TyrosineKinase and its Involvement in Breast Cancer

摘要

The studies outlined in the original proposal were aimed at determining themolecular basis underlying the actions of the neu/erbB2 tyrosine kinase and its involvement in the development and progression of breast cancer. Within this section of the annual report (for the period July 15, 1994-June 15, 1995), I will discuss the background of the research problem (within the context of previous work performed by our laboratory and other laboratories), the purpose of the present research and the methods of approach that are being used.