Mapping of a Human T-Lymphotropic Virus Type I Gag Protein Epitope that Cross-Reacts with Anti-Plasmodium Falciparum Antibodies

摘要

Studies in Palawan, Philippines, and Irian Jaya, Indonesia, showed thatindeterminate human T-lymphotropic virus type I (HTLV-l) Western blot immunoreactivity is due to cross-reacting anti-Plasmodium falciparum antibodies. To further define this immunoreactivity, mapping studies were conducted using the HTLV-l p19 protein to identify the precise epitope that reacts with these antibodies. Anti-P. falciparum anti-body-positive sera from Palawan, Philippines, and Irian Jaya, Indonesia, were studied using overlapping synthetic peptides.