Estrogen-DNA Adducts as Novel Biomarkers for Ovarian Cancer Risk and for Use in Prevention.

摘要

The purpose of this research is to determine the association between ovarian cancer and (1) imbalances in estrogen metabolism that lead to higher levels of estrogen-DNA adducts in urine and/or (2) genetic polymorphisms in selected enzymes that metabolize estrogens. We completed this study as planned, demonstrating that estrogen metabolism is unbalanced in women diagnosed with breast cancer, as detected by the ratio of estrogen-DNA adducts to estrogen metabolites and conjugates (ratio = 91.4 43.1) compared to the balanced estrogen metabolism in the healthy controls (ratio = 24.7 12.7, p<0.0001). In addition women who were homozygous for the catechol-O-methyltransferase allele and the cytochrome P450 1B1 high activity allele had significantly increased DNA adduct ratios and increased odds of having ovarian cancer.