Role of Mg(2+) in the Inactivation of Inwardly Rectifying K(+) Channels in AorticEndothelial Cells

摘要

We have studied the role of Mg2+ in the inactivation of inwardly rectifying K+channels in vascular endothelial cells. Inactivation was largely eliminated in Mg2+-free external solutions and the extent of inactivation was increased by raising Mg02+. The dose-response relation for the reduction of channel open