Role of Accessory Molecule in Endotoxin-Endothelial Interactions and EndothelialBarrier Dysfunction

摘要

This grant has been renegotiated and the new technical objectives are: (1) Todetermine whether LPS induces tyrosine phosphorylation of endothelial cell proteins that can be coupled to changes in barrier function. (2) To determine whether this LPS-induced endothelial intercellular gap formation and barrier dysfunction is due to zonula adherens and/or focal adhesion disassembly. (3) To determine which protein substrates are the targets of LPS-induced tyrosine phosphorylation.