Laser Induced Vitreoretinal Scarring - Evaluation of Causative Factors and aTherapeutic Approach

摘要

Eyes subjected to laser exposure develop an inflammatory reaction, lead toscattering, bleeding ensuing in visual impairment. This study demonstrated two main findings: (1) the angiogenic (neovascularization) activity of vitreous from lasered eye in rats cornea. The DPI an NADPH inhibitor curtailed significantly angiogenesis, as well as the initial vascular response. (2) vitreous of lasered eyes enhances cell proliferation of retinal pigment epithelium, vascular endothel. This unique finding explains the development of visual impairment weeks and months post laser of subjects unaware of being hit by laser. Therefore subjects exposed to laser should be screened regularly to find laser lesions and a therapeutic regimen of antioxidants and/or steroidal should be initiated.