Positron Emitter I124 Iododeoxyuridine as a Tracer to Follow DNA Metabolism onScans and in Tumor Samples in Advanced Breast Cancer

摘要

The objectives of this study are: (1) to determine whether the biologic activityof locally advanced Stage III breast cancer as measured by 1241-iododeoxyuridine (IUdR) uptake on positron emission tomography (PET) scans pre and post chemotherapy can be correlated with the clinical response as determined by physical examination and conventional radiographic studies, (2) to demonstrate that incorporation of TUdR is into the DNA contained within the tumor and that it correlates with the subsequent tumor response and proliferative activity of the tumor, (3) to further assess the biologic activity of tumor sites and clinical response by using a program which fuses PET scan images on computed tomography (CT) scans, magnetic resonance imaging (MRI) or SPECT bone scans.