Development of Novel Models for Describing Multiple Toxicity Effects

摘要

Models of additive and independent response of biological systems to mixtures ofchemical agents have been modified to incorporate interactive (e.g., synergistic, or antagonistic) response. Computer programs to fit these models to experimental data have been developed. An extensive literature review was conducted to obtain data that could be used to test these models. A synoptic review of these data sets is presented. The models developed have, in general, provided an adequate degree of description of the behavior of the chemical mixtures in biological systems. The computer programs could be used for the analysis of data obtained in future experiments.