Inhalation Uptake and Metabolism of Halon 1301 Replacement Candidates, HFC-227ea,HFC-125, and FC-218

摘要

The purpose of this study was to measure the tissue to air partition coefficientsand to describe the uptake and distribution kinetics of bromotrifluoromethane's (Halon 1301) proposed replacement chemicals HFC-227ea, HFC-125, and FC-218. Parallel information pertaining to Halon 1301 and CF(3)I can be found in AL/OE-TR-1994-0068. Tissue to air partition coefficients were determined using the vial equilibration method. Inhalation pharmacokinetics for all Halon 1301 replacements were determined experimentally in Fischer 344 (F-344) male rats via a closed chamber recirculating gas uptake methods. A physiologically-based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these experiments.