Radioprotection by 16,16 Dimethyl Prostaglandin E2 is Equally Effective in Maleand Female Mice

摘要

Radioprotection Icytoprotecionl 16,16 dimethyl prostaglandin E2/sex factors/bonemarrow aplasia Pretreatment with 16,16 dimethyl prostaglandin E2 (DiPGE2) provides effective protection against radiation and chemical injury. Cytoprotection against chemical injury is known to be influenced by sex factors, and is more effective in females than males. Since prostaglandin metabolism and biological responses to prostaglandin may vary between sexes, studies were conducted to compare DiPOErinduced radioprotection in male and female mice. Pretreatment with 400 ug DiPGE2/kg body wt substantially enhanced 30-day survival in males and females. There was no significant difference in the LD50130 of male and female mice receiving vehicle alone prior to irradiation, 8.34 Gy versus 8.46 Gy, respectively. DiPGE2 treatment increased the LD50130 in males to 12.1 Gy, providing a dose modification factor (DMF) of 1.45. Similar increases were observed in females, with a LD50130 of 11.6 and a DMF of 1.37. The reported difference in DipOErinduced cytoprotection between males and females exposed to ethanol injury, and the lack of variation in the present radioprotection study suggests that separate mechanisms are involved in the two processes.