Stereochemistry-Dependent Bending in Oligonucleotide Duplexes Induced by Site-Specific Covalent Benzo(a)pyrene Diol Epoxide-Guanine Lesions

摘要

The apparent persistence length of enzymatically linearized pIB130 plasmid DNAmolecules approx. 2300 bp long, as measured by a hydrodynamic linear flow dichroism method, is markedly decreased after covalent binding of the highly