Range-Finding Study for a Reproductive Screen of Modular Artillery Charge System(XM231/XM232) Administered in the Diet of Sprague-Dawley Rats

摘要

An artillery propellant under development b the U.S. Army is a granular mixtureof nitrocelinlose, nitroglycerin, nitroguanidine, ethylcentralite, cryolite, and graphite. The propellant, Modniar Artillery Charge System or MACS, consists of a single increment of propellant charge contained within a rigid combustible casing. Nitrocellulose, nitroglycerin, and nitroguanidine make up greater than 98% of the total propellant mixture. As part of the process to develop environmental and health effects criteria, a 90-day modified Screening Information Data Set reproductive assay is planned. In order to provide information on clinical signs, methemoglobin formation and possible target