New Trends in Escherichia coli O111:B4 J5 Mutant (Rc chemotype) VaccineDevelopment for Use in Gram-Negative Bacillary Sepsis

摘要

In the course of our studies on the immunotherapy of gram%negativ% bacterialsepsis, we devised an animal model of sepsis which closely mimicked the clinical presentation of sepsis in humans in both the kinetics and level of bacteremia observed as well as in the cytokine profile generate%.