Effect of Triazolam on Responses to a Cold-Water Immersion in Humans

摘要

Managing alertness of soldiers during sustained operations is a source of seriousconcern for military unit commanders. A frequently employed strategy is to induce sleep before an operation, especially operation requiring prolonged travel. Sleep-inducing drugs could have an action on thermoregulation through their effect on alertness and a possible direct effect on the brain. The goal of this study was therefore to evaluate the effect of a commonly prescribed triazolam (Halcion) on thermoregulatory responses to cold-water immersion. Eight subjects were immersed twice in 18 deg C water for up to 90 min in the morning; once after ingesting 0.25 mg triazolam (TRZ) the prior evening, and again after placebo (PLB) treatment. There were no significant differences between trials for mean duration of the immersion, the change in rectal temperature and mean skin temperature.