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Translation of Novel Serotonin 5-HT7 Agonist Drug Candidates in Rodent Models of Fragile X Syndrome.

机译：新型5-羟色胺5-HT7激动剂候选药物在脆性X综合征啮齿动物模型中的翻译。

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作者
Canal, C.; Booth, R.;
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年度 2016
页码 1-11
总页数 11
原文格式 PDF
正文语种 eng
中图分类
关键词
Fragile x syndrome;

机译：脆性x综合症;

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专利

1. Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome [J] . Lacivita Enza, Niso Mauro, Stama Madia Letizia, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2020,第1期

机译：基于脚手架的特权设计，以鉴定一种新的药物样5-HT7受体 - 偏美激动剂，以靶向脆弱的X综合征
2. Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. [J] . Pantaleo Di Pilato, Mauro Niso, Walter Adriani, Reviews in the neurosciences . 2014,第3期

机译：血清素7（5-HT7）受体选择性激动剂及其在临床前模型中的应用：概述。
3. Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and fmr1 knockout mice, a model of fragile X syndrome [J] . CostaL., SpatuzzaM., DAntoniS., Biological psychiatry . 2012,第11期

机译：5-HT7血清素受体的激活逆转了代谢型谷氨酸受体介导的野生型和fmr1基因敲除小鼠的脆弱X综合征模型中的突触可塑性
4. Gene Expression Models of BRAF Inhibitor Resistance in Melanoma Predict Drug Repurposing Candidates for Novel Combination Therapies [C] . Kelly Regan, Andrew R. Stiff, William E. Carson, International Molecular Medicine Tri-Conference. . 2016

机译：黑色素瘤中BRAF抑制剂抗性的基因表达模型预测了新型组合疗法的药物重新培养候选者
5. Drug Design of 5-Substituted-2-Aminotetralins Targeting the Serotonin 5-HT7 Receptor [D] . Perry, Charles K. 2018

机译：针对5-羟色胺5-HT7受体的5-取代-2-氨基四氢萘的药物设计
6. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice a model of Fragile X Syndrome [O] . Lara Costa, Lara M. Sardone, Enza Lacivita, 2015

机译：5-羟色胺5-HT7受体的新型激动剂逆转了代谢型谷氨酸受体介导的野生型和Fmr1 KO小鼠（脆性X综合征模型）海马中的长期抑郁
7. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome [O] . Lara eCosta, Lara Maria Sardone, Enza eLacivita, 2015

机译：用于5-羟色胺5-HT7受体的新型激动剂逆转代谢型谷氨酸受体介导的野生型和Fmr1 KO小鼠海马中的长期抑制，这是脆性X综合征的模型

Translation of Novel Serotonin 5-HT7 Agonist Drug Candidates in Rodent Models of Fragile X Syndrome.

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