Liposomes as Carriers of Peptide Antigens: Induction of Antibodies and CytotoxicT Lymphocytes to Conjugated and Unconjugated Peptides

摘要

Strategies underlying the creation and development of modern vaccines have undergone rapid evolutionary changes both because of the opportunities that have been driven by advances in biotechnology, and because of the challenges that have been imposed by vaccines against complex diseases such as cancer, AIDS, parasitic diseases, and others (Melief l992; Greenberg 1991, Ravetch et al. 1985, Hilleman 1992, Karzon et al. 1992). The enormous magnitude of the diseases facing mankind, as well as the social and economic urgencies involved, have been powerful forces that have imposed imperatives to explore the degree to which technology can be expanded and the limits that exist in the creative scientific boundaries in the general field of vaccines, a field that has now been endowed by Jonas Salk with the unique identifying name of vaccinology (Warren 1986). Among the many major fields that have been heavily stimulated by vaccine research in recent years, major advances of interest to vaccinologists have been made in the areas of antigen development (Berzofsky 1985), and vaccine carrier, vehicle, and adjuvant development.