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Drug Design, Development and Therapy

【机译】：药物设计，开发和治疗

ISSN：-
出版周期：
语言：English

起始发布年份：2007
出版者：[Auckland, N.Z.] : Dove Press Limited
出版地：New Zealand

数据库引入：PubMed: v1, 2007-, PMC

MeSH词表主题词：Drug Design; Drug Therapy*; Pharmaceutical Preparations

备注：Description based on first issue; title from journal homepage (publisher's Web展开▼

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1.Promising Swellable Floating Bupropion Tablets: Formulation in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers

机译：有前途的脱脂浮绒平片：制剂体外/体内评价和人类志愿者的比较药代动力学研究
- 作者：Mahmoud Teaima;Magdi M. Abdel Hamid;Nabil A. Shoman;Bhaskara R. Jasti;Mohamed A. El-Nabarawi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
2.Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling

机译：丹参酮IIA通过抑制Nogo-A / NGR1 / RoON / Roci / MLC信号传导促进局灶性脑缺血的大鼠轴突再生
- 作者：Jing Wang;Guangxiao Ni;Yanming Liu;Ying Han;Lin Jia;Yali Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
3.Does an Earlier or Late Intravenous Injection of Ondansetron Affect the Dose of Phenylephrine Needed to Prevent Spinal-Anesthesia Induced Hypotension in Cesarean Sections?

机译：ondansetron的较早或晚期静脉注射会影响预防脊髓麻醉诱导的剖宫产的低血压所需的剂量吗？
- 作者：Jing Qian;Lin Liu;Xiufeng Zheng;Fei Xiao
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
4.A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection

机译：合成肽2ABZ23S29减少细菌滴度并在尿路感染的小鼠模型中诱导促炎细胞因子
- 作者：Neda Moazzezy;Mohammad Reza Asadi Karam;Sima Rafati;Saeid Bouzari;Mana Oloomi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
5.Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes

机译：Lentinan抑制年龄诱导的炎症和人软骨细胞中基质降解酶的表达
- 作者：Zhaozhen Zhang;Zhuqing Zha;Zhiwei Zhao;Wenjing Liu;Wuyin Li
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
6.The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation

机译：不同剂量的Aliskiren在炎症大鼠模型中的抗炎作用
- 作者：Tavga Ahmed Aziz;Ahmed Azad Kareem;Hemn Hassan Othman;Zheen Aorahman Ahmed
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
7.Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis

机译：丹参酮IIA通过调节MIR-133A-3P / EGFR轴来调节心脏H9C2细胞增殖和细胞凋亡来改善CAD的进展
- 作者：Hong Xu;Haiqing Li;Pengxiong Zhu;Yun Liu;Mi Zhou;Anqing Chen
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
8.Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation

机译：间充质基质细胞源细胞间囊泡对脑缺血再灌注诱导的神经功能损伤的神经保护作用：AMPK和JAK2 / Stat3 / NF-κB信号传导途径调制的关键作用
- 作者：Min Han;Ying Cao;Hao Xue;Xili Chu;Tingting Li;Danqing Xin;Lin Yuan;Hongfei Ke;Gang Li;Zhen Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
9.Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes

机译：LorataDine减轻了先进的糖化末期产品诱导人类软骨细胞中NLRP3炎症的活化
- 作者：Feng Gao;Shanyong Zhang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
10.Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p

机译：雷丝酮通过上调miR-181b-5p抑制IL22诱导的HACAT细胞的增殖
- 作者：Qi He;Bo Zhang;Feng Hu;Jianwen Long;Quan Shi;Xianming Pi;Hongxiang Chen;Jiawen Li
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
11.The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma

机译：Dexmedetomidine和氯胺酮对钝胸创伤后氧化损伤和组织学变化的影响
- 作者：Seyfi Kartal;Gülay Kip;Ayşegül Küçük;Seyhan Sümeyra Aşçı;Özlem Erdem;Mustafa Arslan;Mustafa Kavutçu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
12.Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by NN-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer

机译：胰腺癌中NN-二甲基叔氨基部分在胰腺癌中提高紫杉醇加载的聚乙二醇化脂质体的抗肿瘤效果
- 作者：Yang Chen;Li Wang;Shi Luo;Jun Hu;Xing Huang;Pei-Wen Li;Yi Zhang;Chao Wu;Bo-Le Tian
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
13.Potential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen of S. sanguinis ATCC 10556 and as Inhibitor of MurA Enzymes: in vitro and in silico Study

机译：潜在的烯丙基丙酰衍生物作为抗菌剂的抗菌剂免受S.Sanguinis ATCC 10556和Mura酶的抑制剂：体外和硅研究
- 作者：Dikdik Kurnia;Geofanny Sarah Hutabarat;Devi Windaryanti;Tati Herlina;Yetty Herdiyati;Mieke Hemiawati Satari
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
14.Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

机译：冬虫夏素通过破坏CentrosomeSoosoTasis抑制人类妊娠期胆管癌细胞生长
- 作者：Chia-Yih Wang;Shih-Wei Tsai;Han-Hsiang Chien;Ting-Yu Chen;Shi-Yuan Sheu;Edmund Cheung So;Bu-Miin Huang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
15.Botulinum Toxin Type A Possibly Affects Cav3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity

机译：Botulinum毒素类型A可能会影响脊髓损伤肌痉挛大鼠的Cav3.2钙通道亚基
- 作者：Kening Ma;Dan Zhu;Chunguo Zhang;Lijie Lv
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
16.Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers

机译：橘子和阿托伐他汀对结肠癌联合治疗的协同作用：使用RGD肽装饰纳米载体的这些双药的靶向递送
- 作者：He Bao;Nanbo Zheng;Zhuanting Li;Yuan Zhi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
17.In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 74ʹ-Dimethyl Ether

机译：在体内筛选天然产物免受脱氧酮B 74-二甲醚的抗血管生成活性抗血管生成活性机制
- 作者：Kan Chen;Yuqi Fan;Jun Gu;Zhihua Han;Huasu Zeng;Chengyu Mao;Changqian Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
18.Antibacterial of Dibenzo-p-Dioxi-28-Dicarboxylic Acid Against Pathogenic Oral Bacteria E. faecalis ATCC 29212 Peptide Pheromones: Quorum Sensing of in vitro and in silico Study

机译：抗菌性抗菌性抗菌性口腔细菌抗菌抗菌性口腔细菌大肠杆菌ATCC 29212肽信息素：体外和硅研究的批量传感
- 作者：Dikdik Kurnia;Putri Rachmawati;Mieke H Satari
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
19.Nano-Graphene Oxide-supported APTES-Spermine as Gene Delivery System for Transfection of pEGFP-p53 into Breast Cancer Cell Lines

机译：纳米石墨烯氧化物支持的Aptes-菲尔明作为基因递送系统用于将PEGFP-P53转染到乳腺癌细胞系中
- 作者：Vida Mirzaie;Mehdi Ansari;Seyed Noureddin Nematollahi-Mahani;Mahshid Moballegh Nasery;Behzad Karimi;Touba Eslaminejad;Yaghoub Pourshojaei
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
20.Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

机译：姜黄素可以防止放疗诱导的皮肤氧化损伤
- 作者：Dheyauldeen Shabeeb;Ahmed Eleojo Musa;Hayder Shabeeb Abd Ali;Masoud Najafi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
21.Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury

机译：褪黑激素通过调节miR-26a-5p-nRSF和JAK2-STAT3途径来改善脑缺血再灌注损伤的自噬炎症和氧化应激来发挥保护作用
- 作者：Bo Yang;Li-E Zang;Jing-Wen Cui;Ming-Yuan Zhang;Xue Ma;Lin-Lin Wei
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
22.Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil

机译：考虑到Deinpezil的CYP2D6基因型依赖性代谢的Rivastigmine和Denpezil的治疗药物监测
- 作者：Marion Ortner;Marion Stange;Heike Schneider;Charlotte Schröder;Katharina Buerger;Claudia Müller;Felix Müller-Sarnowski;Janine Diehl-Schmid;Hans Förstl;Timo Grimmer;Werner Steimer
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
23.Atorvastatin Combined with Low-Dose Dexamethasone Treatment Protects Endothelial Function Impaired by Chronic Subdural Hematoma via the Transcription Factor KLF-2

机译：阿托伐他汀联合低剂量地塞米松治疗通过转录因子KLF-2保护慢性硬膜血肿损害的内皮函数
- 作者：Yueshan Fan;Dong Wang;Chenxu Rao;Ying Li;Hongtao Rong;Zengguang Wang;Jianning Zhang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
24.Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer

机译：Erianin对人结肠癌癌细胞生长和吞噬作用的双重靶向
- 作者：Yihan Sun;Guofeng Li;Qi Zhou;Danyue Shao;Jingwei Lv;Jianhua Zhou
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
25.Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

机译：评估新的人参皂苷RH2纳米瘤制剂用于增强前列腺癌的抗肿瘤疗效：体外研究
- 作者：Hadi Zare-Zardini;Ashraf Alemi;Asghar Taheri-Kafrani;Seyed Ahmad Hosseini;Hossein Soltaninejad;Amir Ali Hamidieh;Mojtaba Haghi Karamallah;Majid Farrokhifar;Mohammad Farrokhifar
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
26.Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model

机译：Genistein对OB / OB小鼠模型中糖尿病诱导脑损伤的有益效果
- 作者：Rong-zi Li;Xiao-Wen Ding;Thangiah Geetha;Layla Al-Nakkash;Tom L Broderick;Jeganathan Ramesh Babu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
27.New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis

机译：通过阻断TNF-α合成新的苯并呋喃N-酰基腙在肥胖大鼠中减少心血管功能障碍
- 作者：Gizele Cabral Costa;Tadeu Lima Montagnoli;Jaqueline Soares Da Silva;Allan Kardec Nogueira de Alencar;Luis Eduardo Reina Gamba;Bryelle Eccard Oliveira Alves;Marina Moraes Carvalho da Silva;Margarete Manhães Trachez;José Hamilton M do Nascimento;Pedro Moreno Pimentel-Coelho;Rosália Mendez-Otero;Lidia Moreira Lima;Eliezer J Barreiro;Roberto Takashi Sudo;Gisele Zapata-Sudo
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
28.Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model

机译：大麻提取物CT-921在神经性疼痛模型中具有高疗效不良反应谱
- 作者：Elham Rouhollahi;Bernard A MacLeod;Alasdair M Barr;Ernest Puil
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
29.Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4

机译：前列腺癌相关成纤维细胞的肉桂醛治疗可防止其通过Toll样受体4对T细胞的抑制作用
- 作者：Jie Mei;Jing Ma;Yuwei Xu;Yuanyuan Wang;Minghua Hu;Fangli Ma;Zhihai Qin;Rui Xue;Ning Tao
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
30.Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective Double Blind Randomized Controlled Study

机译：罗酮溴化物对止血带骨骼肌缺血再灌注损伤的保护作用在接受选修单侧全膝关节置换术患者中的脑肌轴承术：一种前瞻性双盲随机对照研究
- 作者：Hui Chen;Jing-Qiu Wei;Yi-Wen Wang;Kun-Peng Zhou;Ying He;He Liu;Yue-Ying Zhang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
31.Cyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H2S-Regulated AMPK/mTOR Pathway

机译：通过抑制H2S调节的AMPK / MTOR途径Cyanidin-3-O-葡糖苷改善严重急性胰腺炎的结肠运动性
- 作者：Wei Lian;Wensheng Chen
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
32.Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy

机译：Galangin通过促进自噬改善了小鼠的非酒精脂肪肝疾病
- 作者：Xinxu Zhang;Yuanyuan Deng;Juan Xiang;Huixia Liu;Jiani Zhang;Jie Liao;Ke Chen;Bo Liu;Jun Liu;Ying Pu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
33.Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation

机译：具有严重眼炎症兔环磷酰胺的亚叛股微灌注的疗效
- 作者：Libei Zhao;Manqiang Peng;Wenxiang Lin;Qian Tan;Muhammad Ahmad Khan;Ding Lin
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
34.Carboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis

机译：Carboplatin通过IncRNA XIST / MIR-200A-3P / NRP1轴抑制视网膜母细胞瘤的进展
- 作者：Hong Zhao;Jingjing Wan;Yu Zhu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
35.Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

机译：Sarsasapoolain抑制体外诱导的RANKL诱导的骨酸核并防止体内脂多糖诱导的骨质损失
- 作者：Jiaxuan Peng;Kangxian Zhao;Jiling Zhu;Yanben Wang;Peng Sun;Qichang Yang;Tan Zhang;Weiqi Han;Wenjun Hu;Wanlei Yang;Jianwei Ruan;Yu Qian
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
36.Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway

机译：左炔诺孕酮通过LNCRNA H19 / MIR-17 / TLR4途径改善腺瘤症
- 作者：Na Liang;Wenfeng Zhang;Hongjiang Wang;Wei Shi;Li Wang;Lijuan Ma
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
37.Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma

机译：Croarterial Chemobolization与索拉非尼患者BCLC阶段C肝细胞癌患者
- 作者：Kai-Cai Liu;Ying-Hong Hao;Wei-Fu Lv;Wei-Dong Jia;Chu-Shu Ji;Chun-Ze Zhou;De-Lei Cheng;Shao-Bao Xu;Zong-Gen Gao;Ming-Xue Su;Chang-Sheng Shi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
38.Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin

机译：乳腺癌患者血浆中的多柔比蛋白和多柔比霉素分析用于监测多柔比星毒性的血浆
- 作者：Yahdiana Harahap;Puspitasari Ardiningsih;Agatha Corintias Winarti;Denni Joko Purwanto
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
39.Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial

机译：视频教育减少癌症患者的疼痛和焦虑水平首先使用芬太尼透皮贴剂：随机对照试验
- 作者：Ziqi Ye;Jie Chen;Yanfang Zhang;Xi Hu;Zixue Xuan;Si Yang;Xiaohong Mao;Yuefeng Rao
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
40.Effectiveness of Metoprolol in Improving Cardiac and Motor Functions in Patients with Chronic Heart Failure: A Prospective Study

机译：富含托洛尔在慢性心力衰竭患者心脏和运动功能方面的有效性：预期研究
- 作者：XiaoLiang Cheng;Min Zhu;Qing Liu;Zhenxia Feng;Yong Meng
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
41.Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo

机译：外肌肉涂覆的miR-34a在体外和体内显示胰腺癌中有效的抗肿瘤活性
- 作者：Ling Zuo;Hongyu Tao;Huanli Xu;Cong Li;Gan Qiao;Mingyue Guo;Shousong Cao;Minghua Liu;Xiukun Lin
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
42.Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective Randomized Double-Blind Controlled Study

机译：静脉注射利用椰油在肥胖患者中进行无痛结肠镜检查的应用：一种前瞻性随机双盲对照研究
- 作者：Xiaoxiao Li;Xueli Lv;Zhenfei Jiang;Xinrui Nie;Xinghe Wang;Tong Li;Lianyi Zhang;Su Liu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
43.Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification

机译：骨靶向脂质体包封的萨尔维亚甲酸A通过调节HDAC3介导的胚胎骨化来改善非愈合
- 作者：Limin Zhou;Haojun Wu;Xiang Gao;Xiaoyan Zheng;Hang Chen;Hailong Li;Jun Peng;Weichong Liang;Wenxing Wang;Zuocheng Qiu;Anjaneyulu Udduttula;Kefeng Wu;Lin Li;Yuyu Liu;Yanzhi Liu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
44.Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer

机译：Futostatin与Tamoxifen组合诱导ER阳性乳腺癌的协同抑制
- 作者：Ying Liu;Ning Zhang;Hanwen Zhang;Lijuan Wang;Yi Duan;Xiaolong Wang;Tong Chen;Yiran Liang;Yaming Li;Xiaojin Song;Chen Li;Dianwen Han;Bing Chen;Wenjing Zhao;Qifeng Yang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
45.LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway

机译：LNCRNA PVT1通过灭活TGF-β信号通路抑制肾纤维化的进展
- 作者：Lu Cao;Peng Qin;Jianjiang Zhang;Huiju Qiao;Peipei Shi;Huali Huo
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
46.Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

机译：通过调节HGF和TGFβ-SMAD信号通路通过调节HGF和TGFβ-SMAD信号通路的大素延迟肾纤维化
- 作者：Fan Yang;Lu Deng;JinPeng Li;MuHu Chen;Ying Liu;YingChun Hu;Wu Zhong
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
47.Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway

机译：Pinocembrin改善了血管性痴呆症引起的认知障碍：Reelin-DAB1信号通路的贡献
- 作者：Ze-Chun Kang;Hai-Gang Wang;Yu-Lin Yang;Xiao-Yue Zhao;Qi-Meng Zhou;Ying-Lin Yang;Jing-Yu Yang;Guan-Hua Du
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
48.Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine

机译：通过在Lipofectamine上装饰的双促进剂载体增强HEK-293细胞系中的丁二醇胆碱酯酶活性
- 作者：Vida Mirzaie;Touba Eslaminejad;Homayoon Babaei;Seyed Noureddin Nematollahi-Mahani
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
49.Computational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders

机译：（e）-2-（4-甲氧基苄基）环戊酮用于神经系统疾病治疗潜力的计算和药理学研究
- 作者：Sabah Farooq;Arif-ullah Khan;Muhammad Shahid Iqbal
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
50.Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation

机译：基于网络药理学方法和实验验证的胃醋酸对胃癌细胞抑制作用的研究
- 作者：Youqiang Liu;Yanlin Ma;Zheng Li;Yang Yang;Bin Yu;Zhenya Zhang;Guiying Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
51.Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p

机译：LNCRNA HOXA-AS3的敲低通过海绵MIR-455-5P抑制动脉粥样硬化的进展
- 作者：Kui Chi;Jinwen Zhang;Huanhuan Sun;Yang Liu;Ye Li;Tao Yuan;Feng Zhang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
52.Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway

机译：Emodin通过抑制ILK / GSK-3β途径反转人子宫内膜基质细胞的上皮 - 间充质转变
- 作者：Qiaomei Zheng;Jinhua Wang;Wenwen Li;Xiaoyun Chen;Shaozhan Chen;Lihong Chen
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
53.Comparison of GnRH-a Prolonged Protocol and Short GnRH-a Long Protocol in Patients with Thin Endometrium for Assisted Reproduction: A Retrospective Cohort Study

机译：GNRH-A延长的议定书和短GNRH-A患者患者辅助繁殖繁殖的患者的比较：回顾性队列研究
- 作者：Jianyuan Song;Cuicui Duan;Wangyu Cai;Wei Wu;Houyi Lv;Jian Xu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
54.LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury

机译：在脑缺血再灌注损伤期间通过海绵MiR-449C-5P和Up-Consemate Stat6衰减炎症反应在脑缺血再灌注损伤期间
- 作者：Shuo Zhang;Wen-chong Sun;Zuo-di Liang;Xiu-ru Yin;Zhen-rong Ji;Xiao-huan Chen;Min-jie Wei;Ling Pei
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
55.Formulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization in vitro ‎Characterization and ex vivo Permeation Study

机译：作为改善天然白酮抑制剂（3-乙酰-11- keto-β-骨盆酸）的局部递送的有希望的方法：统计优化体外渗透研究和离体渗透研究
- 作者：Farid Badria;Eman Mazyed
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
56.Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent

机译：N-（4-氯苯基）-4-甲氧基-3-（甲基氨基）苯甲酰胺作为潜在抗HBV剂的合成和生物活性
- 作者：A-Long Cui;Wen-Fang Sun;Zhao-Jin Zhong;Jie Jin;Si-Tu Xue;Shuo Wu;Yu-Huan Li;Zhuo-Rong Li
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
57.The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats

机译：Aliskiren对大鼠慢性间歇性缺氧诱导的心房重塑的潜在影响
- 作者：Shuai Miao;Yu Yang;Ruiling Li;Li Yin;Kai Zhang;Lijun Cheng;Xiaona Xu;Weiding Wang;Zhiqiang Zhao;Guangping Li
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
58.Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis

机译：通过抑制糊酶来源自间充质干细胞的外泌体免受心肌免受缺血/再灌注损伤的影响
- 作者：Jiayou Tang;Lu Jin;Yang Liu;Lanlan Li;Yanyan Ma;Linhe Lu;Jipeng Ma;Peng Ding;Xiuling Yang;Jincheng Liu;Jian Yang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
59.Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels

机译：4-氟-N-（4-磺酰甲苄基）苯磺胺酰胺对尼古丁诱导的行为致敏和纹状腺腺苷水平的影响的影响
- 作者：Naeem Ur Rehman;Muzaffar Abbas;Mariya al-Rashida;Ahmed Tokhi;Muhammad Awais Arshid;Muhammad Sona Khan;Izhar Ahmad;Khalid Rauf
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
60.Quercetin Inhibits Adenomyosis by Attenuating Cell Proliferation Migration and Invasion of Ectopic Endometrial Stromal Cells

机译：槲皮素通过衰减细胞增殖迁移和异位子宫内膜间构间质细胞的侵袭来抑制腺脓剂
- 作者：Wenbin Xu;Yizuo Song;Kehan Li;Biyun Zhang;Xueqiong Zhu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
61.Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway

机译：富裕的盐水调节微胶质细胞症并通过AKT途径恢复新生儿小鼠缺氧缺血损伤后的行为缺陷
- 作者：Hongfei Ke;Dexiang Liu;Tingting Li;Xili Chu;Danqing Xin;Min Han;Shuanglian Wang;Zhen Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
62.Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding

机译：从HeLa细胞系的婚外链内酯和顺铂组合的协同细胞毒性效应：一种新的发现
- 作者：Sadia Sarwar;Jun Qing Yu;Humaira Nadeem;Fazlul Huq
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
63.Protective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway

机译：pravastatin对miR-93 / nrf2 / is信号途径调节心肌缺血再灌注损伤的保护作用
- 作者：Zhiqiang Liu;Fucheng Zhang;Lipei Zhao;Xueping Zhang;Yibo Li;Lingling Liu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
64.Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice

机译：Phoenixin 14在实验小鼠中抑制高脂饮食诱导的非酒精脂肪肝疾病
- 作者：Fan Yang;Ping Huang;Liandong Shi;Feng Liu;Aimei Tang;Shaohui Xu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
65.Effects of High-Dose Rosuvastatin on Ventricular Remodelling and Cardiac Function in ST-Segment Elevation Myocardial Infarction

机译：高剂量rosuvastatin对节段抬高心肌梗死心室重塑和心功能的影响
- 作者：Rong Luo;Xiaochen Sun;Feiyan Shen;Bin Hong;Zilong Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
66.Integrating Unified Medical Language System and Kleinberg’s Burst Detection Algorithm into Research Topics of Medications for Post-Traumatic Stress Disorder

机译：将统一的医疗语言系统与Kleinberg的突发检测算法集成到创伤后应激障碍药物的研究主题
- 作者：Shuang Xu;Dan Xu;Liang Wen;Chen Zhu;Ying Yang;Shuang Han;Peng Guan
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
67.Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

机译：具有FOSAPREPITANT和5-HT3-受体拮抗剂的避孕预防患者进行自体造血干细胞移植的儿科患者
- 作者：Karin Melanie Cabanillas Stanchi;Semjon Willier;Julia Vek;Patrick Schlegel;Manon Queudeville;Nora Rieflin;Veronika Klaus;Melanie Gansel;Joachim Vincent Rupprecht;Tim Flaadt;Vera Binder;Tobias Feuchtinger;Peter Lang;Rupert Handgretinger;Michaela Döring
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
68.DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

机译：DPP-4抑制剂Linagliptin改善氧化LDL诱导的THP-1巨噬细胞泡沫细胞形成和炎症
- 作者：Haoran Wang;Yue Li;Xiaoliang Zhang;Zhonglin Xu;Jianzhong Zhou;Wei Shang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
69.The Activity and Safety of Anlotinib for Patients with Extremity Desmoid Fibromatosis: A Retrospective Study in a Single Institution

机译：肢体纤维瘤患者ANLOTINIB的活性和安全性：单一机构的回顾性研究
- 作者：Chuanxi Zheng;Yong Zhou;Yitian Wang;Yi Luo;Chongqi Tu;Li Min
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
70.Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase

机译：HSA_CIRC_0059955的敲低通过抑制瘙痒的E3泛素蛋白连接酶诱导细胞核拷贝细胞中的细胞凋亡和细胞周期停滞
- 作者：Daliang Kong;Rui Gu;Chengtao Zhang;Ruofeng Yin
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
71.Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation and Induce Apoptosis via PARP PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells

机译：来自Garcinia Nujiangensis的抗肿瘤X吨数抑制了人类卵巢癌细胞中PARPPI3K / AKT / MTOR和MAPK / ERK信号通路的诱导细胞凋亡
- 作者：Zhongyan Tang;Lihua Lu;Zhengxiang Xia
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
72.Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma

机译：基于结构的虚拟筛选和对多骨髓瘤的抗癌作用的鉴定鉴定新型C-Myc抑制剂7594-0037
- 作者：Ruosi Yao;Yu Xie;Xiaoyang Sun;Menghui Zhang;Jian Zhou;Linlin Liu;Jian Gao;Kailin Xu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
73.Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling

机译：通过抑制氧化应激和炎症提高NRF2 / HO-1信号传导umbelliferone抑制了铅毒毒大鼠的精子缺陷和睾丸损伤
- 作者：Mohammed F Alotaibi;Fakhria Al-Joufi;Howida S Abou Seif;Mohammed A Alzoghaibi;Laiche Djouhri;Ahmad F Ahmeda;Ayman M Mahmoud
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
74.Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds

机译：综合网络药理学分析和实验验证揭示了辣木抗胰岛素抗性抗性作用机制
- 作者：Qiong Huang;Rong Liu;Jing Liu;Qi Huang;Shao Liu;Yueping Jiang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
75.6-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats

机译：6 -Giglingerol通过调节大鼠的TPH / MAO-A / SERT / 5-HT / 5-HT3受体系统来改善顺铂诱导的PICA
- 作者：Qianqian Cheng;Xiaodi Feng;Qi Meng;Yaqi Li;Siqi Chen;Guoen Wang;Ke Nie
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
76.Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats

机译：装载的地塞米松热敏水凝胶抑制了胶原诱导的关节炎大鼠的炎症和疼痛
- 作者：Qi-Shan Wang;Bing-Xin Xu;Kai-Jian Fan;Yun-Wu Li;Jing Wu;Ting-Yu Wang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
77.Charge Transfer Complex of Neostigmine with 23-Dichloro-56-Dicyano-14-Benzoquinone: Synthesis Spectroscopic Characterization Antimicrobial Activity and Theoretical Study

机译：Neostigmine的电荷转移络合物23-二氯-56-二氰基-14-苯并醌：合成光谱表征抗菌活性和理论研究
- 作者：Tarek A Yousef;Essam Ezzeldin;Hatem A Abdel-Aziz;Mohamed H Al-Agamy;Gamal A E Mostafa
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
78.Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy

机译：Wogonin通过抑制NF-κB和TGF-β1/ Smad3信号通路在糖尿病肾病中来改善肾炎和纤维化
- 作者：Zhi-chao Zheng;Wei Zhu;Lei Lei;Xue-qi Liu;Yong-gui Wu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
79.Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells

机译：Aspirin和Celecoxib的新分子机制靶向哺乳动物神经氨酸酶-1阻抗表皮生长因子受体信号轴诱导胰腺癌细胞凋亡
- 作者：Bessi Qorri;William Harless;Myron R Szewczuk
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
80.The Impact of Icariside II on Human Prostate Cancer Cell Proliferation Mobility and Autophagy via PI3K-AKT-mTOR Signaling Pathway

机译：ICARISIDE II对人道前列腺癌细胞增殖迁移率和自噬的影响通过PI3K-AKT-MTOR信号通路
- 作者：Shuang Li;Yunlu Zhan;Yingwei Xie;Yonghui Wang;Yuexin Liu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
81.Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9 Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration

机译：芬太尼盐酸苯基和纳洛酮盐酸钠氯化钠注射液中的物理兼容性和化学稳定性患者控制镇痛给药
- 作者：Peng Chen;Fuchao Chen;Jiexin Lei;Benhong Zhou
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
82.Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo

机译：促购蛋白在体外抑制骨蛋白分化和骨吸收并防止卵巢切除诱导的体内骨质损失
- 作者：Peng Sun;Qichang Yang;Yanben Wang;Jiaxuan Peng;Kangxian Zhao;Yewei Jia;Tan Zhang;Xuanyuan Lu;Weiqi Han;Yu Qian
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
83.Clinical Outcome of Systemic Treatment for Advanced Soft Tissue Sarcoma: Real-Life Perspective in Japan

机译：先进软组织肉瘤系统治疗的临床结果：日本现实透视
- 作者：Tomoki Nakamura;Kunihiro Asanuma;Tomohito Hagi;Akihiro Sudo
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
84.Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized Single Dose 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions

机译：缬沙坦80 mg胶囊两种配方的药代动力学和生物等效性：在禁食和美联储条件下的健康中国志愿者中的随机单剂量4周期交叉研究
- 作者：Qingqing Wu;Xiaodong Wang;Qian Chen;Yang Zou;Xiaoyan Xu;Tingting Li;Chen Yu;Fu Zhu;Kanyin E Zhang;Jingying Jia;Yanmei Liu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
85.Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress

机译：Dexmedetomidine通过调节P-38Mapk和内质网胁迫衰减H9C2心肌细胞中的细胞损伤和凋亡
- 作者：Zhipeng Zhu;Xiaoyan Ling;Hongmei Zhou;Caijun Zhang;Weiwei Yan
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
86.EGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis

机译：EGCG上调UCP3水平以保护来自白细胞介素-1β诱导的细胞凋亡的MIN6胰岛细胞
- 作者：Xu Jia;Ziren Luo;Ying Gao;Hua Liu;Xinghai Liu;Wenli Mai;Hong Liu;Qian Zheng
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
87.Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs

机译：含有羟基硫化物对有意识犬心血管和呼吸功能的影响
- 作者：Yunlu Liu;Lin Wang;Feng Wan;Na Yang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
88.Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation

机译：作为儿科适当剂型的Bucco-粘接膜用于盐酸普罗拉洛醇的全身递送：体外和体内评价
- 作者：Soad A Mohamad;Hesham Salem;Heba A Yassin;Heba F Mansour
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
89.HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition

机译：HLJ2通过抑制NF-κB和上皮 - 间充质转换有效地改善结肠炎相关癌症
- 作者：Huachen Song;Xiaonan Tang;Xiang Li;Yufei Wang;Anjun Deng;Wenjie Wang;Haijing Zhang;Hailin Qin;LianQiu Wu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
90.Simvastatin-Nicotinamide Co-Crystals: Formation Pharmaceutical Characterization and in vivo Profile

机译：辛伐他汀 - 烟酰胺共晶：形成药物表征和体内型材
- 作者：Fahad Mehmood Khan;Mahmood Ahmad;Hafiz Arfat Idrees
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
91.Synthesis and Identification of a Novel Peptide Ac-SDK (Biotin) Proline That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis

机译：一种新型肽AC-SDK（Biotin）脯氨酸的合成和鉴定可引发杀菌矽肺大鼠的抗纤维化作用
- 作者：Jin Wang;Ye Qian;Xuemin Gao;Na Mao;Yucong Geng;Gaojie Lin;Guibin Zhang;Han Li;Fang Yang;Hong Xu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
92.Development Characterization and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System

机译：晶粒固氮自纳乳化药物递送系统的发展表征和体内药代动力学研究
- 作者：Rehab Abdelmonem;Marian Sobhy Azer;Amna Makky;Abdelazim Zaghloul;Mohamed El-Nabarawi;Aly Nada
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
93.ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro

机译：ISL通过在体内和体外下调PI3K / AKT / MTOR途径下调肝细胞癌凋亡和自噬
- 作者：Lei Song;Yi Luo;Shaoling Li;Ming Hong;Qi Wang;Xiaoling Chi;Cong Yang
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
94.Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study

机译：基于微孔的基于微孔的光谱氟化物方法用于定量大鼠血浆中Ravidasvir（新抗慢性丙型肝炎病毒-GT4）及其在药代动力学研究中的应用
- 作者：Mohamed Hefnawy;Mona Al-Shehri;Sara Al-Rashood;Sherif Hammad;Mohammed Alanazi;Nawaf Alsaif;Mostafa Mohammed;Ahmad Obaidullah;Manal El-Gendy
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
95.Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition

机译：Alprostadil注射通过GSK-3β/ NRF2 / HO-1信号介导的凋亡抑制衰减冠状动脉微栓栓塞诱导的心肌损伤
- 作者：Zhenbai Qin;Binghui Kong;Jing Zheng;Xiantao Wang;Lang Li
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
96.Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity

机译：Berberrubine的代谢活化和共价蛋白质结合：洞察与其肝毒性有关的潜在机制
- 作者：Kai Wang;Jinqiu Rao;Tingting Zhang;Qing Gao;Jichao Zhang;Chenxi Guang;Liqin Ding;Feng Qiu
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
97.LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay

机译：LC-MS / MS估计人肝微粒体中抗癌剂甘蛋白水平：代谢稳定性评估测定
- 作者：Mohamed W Attwa;Ali S Abdelhameed;Nasser S Al-Shakliah;Adnan A Kadi
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
98.Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase

机译：通过激活AMP活化的蛋白激酶白藜芦醇通过激活来保护骨细胞抵抗地塞米松诱导的细胞毒性
- 作者：Liang Wang;Qiushi Li;Haibo Yan;Guangjun Jiao;Hongliang Wang;Hai Chi;Hongming Zhou;Lu Chen;Yu Shan;Yunzhen Chen
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
99.Enhancement of Pancreatic Cancer Therapy Efficacy by Type-1 Matrix Metalloproteinase-Functionalized Nanoparticles for the Selective Delivery of Gemcitabine and Erlotinib

机译：通过1型基质金属蛋白酶官能化纳米粒子来增强胰腺癌治疗效果进行蛋白酶蛋白和欧尔替尼的选择性递送
- 作者：Na Yin;Hui Yu;Xiaodi Zhang;Xiaodan Lv
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期
100.Synthesis Cytotoxic Analysis and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials

机译：通过N-MANNICH基础缩合作为潜在抗微生物的三唑衍生物的合成细胞毒性分析和分子对接研究
- 作者：Ashraf Atef Hatamleh;Dunia Al Farraj;Sarah Salah Al-Saif;SathishKumar Chidambaram;Surendrakumar Radhakrishnan;Idhayadhulla Akbar
- 期刊名称：《Drug Design, Development and Therapy》 | 2020年第-1期