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Clinical and Translational Science

【机译】：临床和转化科学

ISSN：-
出版周期：Bimonthly, 2009-
语言：English

起始发布年份：2008
出版者：Malden, MA : WileyBlackwell Pub., 2008-
出版地：United States

数据库引入：PubMed: v1n1, 2008- ; Selected citations only, PMC

MeSH词表主题词：Biomedical Research*; Clinical Medicine

备注：Title from cover. Print issues ceased with v. 4 (2011) Also issued online.展开▼

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1.Systemic Lupus Erythematosus Activity Affects the Sinusoidal Uptake Transporter OATP1B1 Evaluated by the Pharmacokinetics of Atorvastatin

机译：Systemic Lupus红斑活性会影响由阿托伐他汀的药代动力学评估的正弦摄取运输器oatp1b1
- 作者：Roberta Natália Cestari;Renê Donizeti Ribeiro de Oliveira;Flávio Falcão Lima de Souza;Leandro Francisco Pippa;Glauco Henrique Balthazar Nardotto;Adriana Rocha;Eduardo Antônio Donadi;Vera Lucia Lanchote
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
2.Febuxostat But Not Allopurinol Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

机译：Febuxostat但不是Allopurinol显着提高乳腺癌抗性蛋白质底物血管蛋白血管素的血浆浓度
- 作者：Minna Lehtisalo;Jenni E. Keskitalo;Aleksi Tornio;Outi Lapatto‐Reiniluoto;Feng Deng;Taina Jaatinen;Jenni Viinamäki;Mikko Neuvonen;Janne T. Backman;Mikko Niemi
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
3.Twice‐Daily Doravirine Overcomes the Interaction Effect from Once‐Weekly Rifapentine and Isoniazid in Healthy Volunteers

机译：每日两次Doravirine克服了曾经每周过利福纳州的相互作用效果在健康志愿者身上
- 作者：Edwin Lam;Joseph Schaefer;Richard Zheng;Tingting Zhan;Walter K. Kraft
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
4.Dose‐Dependent Acute Effects of Everolimus Administration on Immunological Neuroendocrine and Psychological Parameters in Healthy Men

机译：艾弗里司血症管理对健康男性免疫学神经内分泌和心理参数的剂量依赖性急性效果
- 作者：Tina Hörbelt;Anna Lena Kahl;Frederike Kolbe;Susann Hetze;Benjamin Wilde;Oliver Witzke;Manfred Schedlowski
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
5.Evaluation of the Effect of Maribavir on Cardiac Repolarization in Healthy Participants: Thorough QT/QTc Study

机译：Maribavir对健康参与者心脏再渗灵极化的影响：彻底QT / QTC研究
- 作者：Katarina Ilic;Ivy Song;Jingyang Wu;Patrick Martin
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
6.Serum Metabolomic Profiles Associated With Untreated Metabolic Syndrome Patients in the Chinese Population

机译：与未经处理的代谢综合征患者在中国人口相关的血清代谢物谱
- 作者：Yuanyuan Li;Yongfa Wang;Yaodong Zhuang;Ping Zhang;Shujiao Chen;Tetsuya Asakawa;Bizhen Gao
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
7.Perioperative Dexmedetomidine Improves Outcomes of Kidney Transplant

机译：围手术期Dexmedetomidine改善了肾移植的结果
- 作者：Jun Chen;Richard Perez;Angelo Mario de Mattos;Cecilia Wang;Zhongmin Li;Richard L. Applegate II;Hong Liu
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
8.CYP2C19 Allele Frequencies in Over 2.2 Million Direct‐to‐Consumer Genetics Research Participants and the Potential Implication for Prescriptions in a Large Health System

机译：CYP2C19等位基因频率超过220万辆直接的消费者遗传学研究参与者以及大型卫生系统中处方的潜在含义
- 作者：Yelena Ionova;James Ashenhurst;Jianan Zhan;Hoang Nhan;Cindy Kosinski;Bani Tamraz;Alison Chubb
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
9.Safety Pharmacokinetics and Pharmacodynamics of TD‐0714 a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects

机译：TD-0714的安全性药代动力学和药效学一种新的成人和老年受试者的新型有效的内胚素抑制剂
- 作者：Jitendra Kanodia;Arthur Lo;R. Michael Baldwin;Ken Colley;Kefei Zhou;David L. Bourdet
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
10.A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat

机译：汇总分析三种随机阶段IIA IIA临床试验证实毫无疑问对QTC间隔的临床相关影响
- 作者：Stefan Viktor Vormfelde;Nicole Pezous;Gilbert Lefèvre;Carine Kolly;Ulf Neumann;Pierre Jordaan;Mike Ufer;Eric Legangneux
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
11.Fasting Status and Circadian Variation Must be Considered When Performing AUC‐based Therapeutic Drug Monitoring of Tacrolimus in Renal Transplant Recipients

机译：在进行肾移植受者的凝胶蛋白的基于Auc的治疗药物监测时必须考虑禁食状态和昼夜昼夜变异
- 作者：Marte Theie Gustavsen;Karsten Midtvedt;Ida Robertsen;Jean‐Baptiste Woillard;Jean Debord;Rolf Anton Klaasen;Nils Tore Vethe;Stein Bergan;Anders Åsberg
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
12.First Clinical Study with AP30663 ‐ a K

机译：第一个临床研究AP30663 - A K
- 作者：Pim Gal;Erica S. Klaassen;Kirsten R. Bergmann;Mahdi Saghari;Jacobus Burggraaf;Michiel J. B. Kemme;Christina Sylvest;Ulrik Sørensen;Bo H. Bentzen;Morten Grunnet;Jonas G. Diness;Nils Edvardsson
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
13.Early M‐Protein Dynamics Predicts Progression‐Free Survival in Patients With Relapsed/Refractory Multiple Myeloma

机译：早期的M-蛋白动态预测复发/难治性多发性骨髓瘤患者的无进展生存期
- 作者：Xiaoyu Yan;Xu Steven Xu;Katja C. Weisel;Maria‐Victoria Mateos;Pieter Sonneveld;Meletios A. Dimopoulos;Saad Zafar Usmani;Nizar J. Bahlis;Thomas Puchalski;Jon Ukropec;Kevin Bellew;Qi Ming;Steven Sun;Honghui Zhou
- 期刊名称：《Clinical and Translational Science》 | 2020年第6期
14.G970R‐CFTR Mutation (c.2908GC) Results Predominantly in a Splicing Defect

机译：G970R-CFTR突变（C.2908G C）主要导致拼接缺陷
- 作者：Meredith C. Fidler;Alexandra Buckley;James C. Sullivan;Marvin Statia;Sylvia F. Boj;Robert G. J. Vries;Anne Munck;Mark Higgins;Matteo Moretto Zita;Paul Negulescu;Fredrick van Goor;Kris De Boeck
- 期刊名称：《Clinical and Translational Science》 | 2021年第2期
15.GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel‐Based Chemotherapy in Ovarian Cancer

机译：GSTP1和ABCB1多态性预测卵巢癌中卡铂和紫杉醇化疗的毒性和临床管理
- 作者：Amanda Canato Ferracini;Leisa Lopes-Aguiar;Gustavo Jacob Lourenço;Adriana Yoshida;Carmen Silva Passos Lima;Luis Otávio Sarian;Sophie Derchain;Deanna L. Kroetz;Priscila Gava Mazzola
- 期刊名称：《Clinical and Translational Science》 | 2021年第2期
16.In Silico Approach to Predict Severe Cutaneous Adverse Reactions Using the Japanese Adverse Drug Event Report Database

机译：在硅方法中预测使用日本不利药物事件报告数据库的严重皮肤不良反应
- 作者：Kaori Ambe;Kazuyuki Ohya;Waki Takada;Masaharu Suzuki;Masahiro Tohkin
- 期刊名称：《Clinical and Translational Science》 | 2021年第2期
17.The COVID‐19 crisis as an opportunity to strengthen global regulatory coordination for sustained enhanced access to diagnostics and therapeutics

机译：Covid-19危机作为加强全球监管协调的机会以便持续加强诊断和治疗
- 作者：Uttara Soumyanarayanan;Mimi Choong;James Leong;Murray M. Lumpkin;Guido Rasi;John H. Skerritt;Silke Vogel;John C. W. Lim
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
18.Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective

机译：NAFLD中药物治疗方案的批判性需要：儿科的观点
- 作者：Chance S. Friesen;Sherwin S. Chan;Jonathan B. Wagner;Chelsea Hosey‐Cojocari;Iván L. Csanaky;Valentina Shakhnovich
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
19.Leveraging innovative technology to generate drug response phenotypes for the advancement of biomarker‐driven precision dosing

机译：利用创新技术为生物标志物驱动的精密剂量推进产生药物反应表型
- 作者：Akinyemi Oni‐Orisan;Nithya Srinivas;Krina Mehta;Jesmin Lohy Das;Thu T. Nguyen;Geoffrey H. Tison;Scott R. Bauer;Maria Burian;Ryan S. Funk;Richard A. Graham
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
20.Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae

机译：用于治疗脑袋和由自由致命的脑袋弥漫性感染的药物
- 作者：Alexandre Taravaud;Zineb Fechtali‐Moute;Philippe M. Loiseau;Sébastien Pomel
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
21.Overview of the Premarketing and Postmarketing Requirements for Drugs Granted Japanese Conditional Marketing Approval

机译：对毒品的预售和上市要求概述授予日本有条件营销批准
- 作者：Shunsuke Matsushita;Keisuke Tachibana;Tetsuya Kusakabe;Ryuichi Hirayama;Yasuo Tsutsumi;Masuo Kondoh
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
22.Early Clinical Experience With AZD4831 A Novel Myeloperoxidase Inhibitor Developed for Patients With Heart Failure With Preserved Ejection Fraction

机译：AZD4831的早期临床经验一种新型髓过氧化物酶抑制剂为心力衰竭患者开发保存的射血分数
- 作者：Karin Nelander;Maria Lagerstrom‐Fermer;Carl Amilon;Erik Michaëlsson;Maria Heijer;Magnus Kjaer;Muir Russell;David Han;Eva‐Lotte Lindstedt;Carl Whatling;Li‐Ming Gan;Hans Ericsson
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
23.A Phase I Randomized Double‐Blind Placebo‐Controlled Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects

机译：I期随机双盲安慰剂控制单剂量和健康受试者BTK抑制剂TAK-020的多重上升剂量研究
- 作者：Ehsanollah Esfandiari;Mary Chen;Glennda Smithson;Derek Blair;Helene Faessel;John Wagner;Lachy Mclean;Eric R. Fedyk
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
24.Effects on the Ocular Surface from Reading on Different Smartphone Screens: A Prospective Randomized Controlled Study

机译：不同智能手机屏幕上读取眼表面的影响：一项潜在随机对照研究
- 作者：Kelan Yuan;Haiping Zhu;Yujie Mou;Yaying Wu;Jingliang He;Xiaodan Huang;Xiuming Jin
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
25.Sarcopenia in Patients With Normal Body Mass Index Is an Independent Predictor for Postoperative Complication and Long‐Term Survival in Gastric Cancer

机译：患有正常体重指数的患者的肌钙蛋白是胃癌术后并发症和长期存活的独立预测因子
- 作者：Xiangwei Sun;Jianfeng Xu;Xiaodong Chen;Weiteng Zhang;Wenjing Chen;Ce Zhu;Jing Sun;Xinxin Yang;Xiang Wang;Yingying Hu;Yiqi Cai;Xian Shen
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
26.Tyrosine Kinase Inhibitors Reduce Glucose Uptake by Binding to an Exofacial Site on hGLUT‐1: Influence on 18F‐FDG PET Uptake

机译：酪氨酸激酶抑制剂通过与Hglut-1的外缺位结合来减少葡萄糖摄取：对18F-FDG宠物摄取的影响
- 作者：Vijaya L. Damaraju;Maral Aminpour;Michelle Kuzma;Philip Winter;Jordane Preto;Jack Tuszynski;Alexander B.J. McEwan;Michael B. Sawyer
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
27.Clinical Evaluation of an Investigational 5 mL Wearable Injector in Healthy Human Subjects

机译：在健康人体受试者中调查5 mL可穿戴注射器的临床评价
- 作者：Wendy D. Woodley;Wen Yue;Didier R. Morel;Audrey Lainesse;Ronald J. Pettis;Natasha G. Bolick
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
28.A Randomized Phase I Study to Evaluate the Safety Tolerability and Pharmacokinetics of Recombinant Erwinia Asparaginase (JZP‐458) in Healthy Adult Volunteers

机译：我研究的随机阶段以评估健康成人志愿者中重组Erwinia天冬酰胺酶（JZP-458）的安全性耐受性和药代动力学
- 作者：Tong Lin;Martha Hernandez‐Illas;Andres Rey;Jack Jenkins;Reddy Chandula;Jeffrey A. Silverman;Mi Rim Choi
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
29.Outreach to new mothers through direct mail and email: recruitment in the Early Check research study

机译：通过直接邮寄和电子邮件向新母亲提供外展：在早期检查研究学习中招聘
- 作者：Ryan S. Paquin;Megan A. Lewis;Blake A. Harper;Rebecca R. Moultrie;Angela Gwaltney;Lisa M. Gehtland;Holly L. Peay;Martin Duparc;Melissa Raspa;Anne C. Wheeler;Cynthia M. Powell;Nancy M. P. King;Scott M. Shone;Donald B. Bailey Jr
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
30.Outcomes of concurrent versus sequential icotinib therapy and chemotherapy in advanced non‐small cell lung cancer with sensitive EGFR mutations

机译：同期结果与顺序icotinib治疗和化疗在先进的非小细胞肺癌中具有敏感的EGFR突变
- 作者：Yun Zhang;Jing Wang;Zhuang Yu;Hong Ge;Lin‐Wei Zhang;Ling‐Xin Feng
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
31.SARS‐CoV‐2 infection as a trigger of autoimmune response

机译：SARS-COV-2感染作为自身免疫反应的触发
- 作者：Maria C. Sacchi;Stefania Tamiazzo;Paolo Stobbione;Lisa Agatea;Piera De Gaspari;Anna Stecca;Ernesto C. Lauritano;Annalisa Roveta;Renato Tozzoli;Roberto Guaschino;Ramona Bonometti
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
32.Evaluation of the performance of a prior tacrolimus population pharmacokinetic kidney transplant model among adult allogeneic hematopoietic stem cell transplant patients

机译：成人同种异体造血干细胞移植患者成人同种异体造血干细胞移植患者的前兆子群体药代动力学肾移植模型的表现评价
- 作者：Jing Zhu;Olivia Campagne;Chad D. Torrice;Gabrielle Flynn;Jordan A. Miller;Tejendra Patel;Oscar Suzuki;Jonathan R. Ptachcinski;Paul M. Armistead;Tim Wiltshire;Donald E. Mager;Daniel L. Weiner;Daniel J. Crona
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
33.Adverse event profiles of epidermal growth factor receptor‐tyrosine kinase inhibitors in cancer patients: A systematic review and meta‐analysis

机译：表皮生长因子受体 - 酪氨酸激酶抑制剂在癌症患者中的不良事件谱：系统审查和荟萃分析
- 作者：Xiaonan Yin;Zhou Zhao;Yuan Yin;Chaoyong Shen;Xin Chen;Zhaolun Cai;Jian Wang;Zhixin Chen;Yiqiong Yin;Bo Zhang
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
34.Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers

机译：膳食时序对健康男性志愿者藏替亚唑的药代动力学和药效学的影响
- 作者：Deok Y. Yoon;Jung Sunwoo;Naree Shin;Ah R. Kim;Bongtae Kim;Geun S. Song;In‐Jin Jang;SeungHwan Lee
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
35.Population pharmacokinetic and exposure‐response analyses of ivosidenib in patients with IDH1‐mutant advanced hematologic malignancies

机译：IVOSidenib患者IVOSIDENIB患者的人口药代动力学和暴露 - 反应分析晚期血液学恶性肿瘤
- 作者：Xuemin Jiang;Russ Wada;Bill Poland;Huub Jan Kleijn;Bin Fan;Guowen Liu;Hua Liu;Stephanie Kapsalis;Hua Yang;Kha Le
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
36.A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype

机译：甲蛋白和多西紫杉醇与甲基化检查点甲基化检查点具有叉头和无牙线指导域启动子和/或微卫星不稳定性表型
- 作者：Marina Baretti;Enusha Karunasena;Marianna Zahurak;Rosalind Walker;Yang Zhao;Thomas R. Pisanic 2nd;Tza‐Huei Wang;Tim F. Greten;Austin G. Duffy;Elske Gootjes;Gerrit Meijer;Henk M.W. Verheul;Nita Ahuja;James G. Herman;Nilofer S. Azad
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
37.Hypomethylation of NLRP3 gene promoter discriminates glucocorticoid‐resistant from glucocorticoid‐sensitive idiopathic nephrotic syndrome patients

机译：NLRP3基因启动子的低甲基化鉴别糖皮质激素敏感性特发性肾病综合征患者鉴别糖皮质激素抗性
- 作者：Marianna Lucafò;Simona Granata;Erik J. Bonten;Robert McCorkle;Gabriele Stocco;Chiara Caletti;Davide Selvestrel;Alessio Cozzarolo;Chan Zou;Eva Cuzzoni;Andrea Pasini;Giovanni Montini;Giovanni Gambaro;Giuliana Decorti;William Evans;Gianluigi Zaza
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
38.Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis

机译：改变的维生素在人肝切片中的代谢对应于纤维发生
- 作者：Lindsay C. Czuba;Xia Wu;Weize Huang;Nicole Hollingshead;Jessica B. Roberto;Heidi L. Kenerson;Raymond S. Yeung;Ian N. Crispe;Nina Isoherranen
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
39.A target‐mediated drug disposition population pharmacokinetic model of GC1118 a novel anti‐EGFR antibody in patients with solid tumors

机译：一种靶介导的药物处理群体GC1118的药代动力学模型一种新型抗EGFR抗体实体肿瘤患者
- 作者：Tae Kyu Chung;Hyun A. Lee;Sang‐In Park;Do‐Youn Oh;Keun‐Wook Lee;Jin Won Kim;Jee Hyun Kim;Ahmi Woo;Su Jin Lee;Yung‐Jue Bang;Howard Lee
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
40.Real‐world evidence of population differences in allopurinol‐related severe cutaneous adverse reactions in East Asians: A population‐based cohort study

机译：欧妥嘌呤醇相关严重皮肤不良反应的人口差异的现实世界：基于人群的队列研究
- 作者：Tsugumichi Sato;Ching‐Lan Cheng;Heung‐Woo Park;Yea‐Huei Kao Yang;Min‐Suk Yang;Mizuki Fujita;Yuji Kumagai;Masahiro Tohkin;Yoshiro Saito;Kimie Sai
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
41.Regulatory and operational challenges in conducting Asian International Academic Trial for expanding the indications of cancer drugs

机译：对扩大癌症药物迹象的亚洲国际学术审判进行监管和经营挑战
- 作者：Tomomi Hata;Kenichi Nakamura;Kan Yonemori;Emi Noguchi;Makiko Watanabe;Joohyuk Sohn;Yen‐Shen Lu;Yoon‐Sim Yap;Kenji Tamura;Yasuhiro Fujiwara
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
42.Rigor and reproducibility training for first year medical students in research pathways

机译：第一年在研究途径中医学生的严谨性和可重复性培训
- 作者：Kate L. Lapane;Catherine E. Dube
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
43.Characterization of LY2775240 a selective phosphodiesterase‐4 inhibitor in nonclinical models and in healthy subjects

机译：Ly2775240一种选择性磷酸二酯酶-4抑制剂在非临床模型和健康受试者中的表征
- 作者：Dipak R. Patel;Shweta Urva;Stephen Ho;Cody J. Buckman;Yanfei Ma;Jean Lim;Sean E. Sissons;Mary S. Zuniga;Diane Philips;Karen Cox;Daniel J. Dairaghi
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
44.Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity metabolism and accumulation

机译：表征使用肝脏微生物学系统进行测定药物毒性新陈代谢和积累的重现性
- 作者：Andrés Rubiano;Amruta Indapurkar;Ryosuke Yokosawa;Alina Miedzik;Barry Rosenzweig;Ayesha Arefin;Chloe M. Moulin;Keri Dame;Neil Hartman;Donna A. Volpe;Murali K. Matta;David J. Hughes;David G. Strauss;Tomasz Kostrzewski;Alexandre J. S. Ribeiro
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
45.Compassionate use of ruxolitinib in patients with SARS‐Cov‐2 infection not on mechanical ventilation: Short‐term effects on inflammation and ventilation

机译：富于SARS-COV-2感染患者的富含ruxolitinib的富于机械通气：对炎症和通风的短期影响
- 作者：Andrea Mortara;Simone Mazzetti;Davide Margonato;Pietro Delfino;Chiara Bersano;Francesco Catagnano;Marinella Lauriola;Paolo Grosso;Gianluca Perseghin;Giovanbattista Ippoliti
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
46.Hybrid physiologically‐based pharmacokinetic model for remdesivir: Application to SARS‐CoV‐2

机译：基于杂交生理学药代动力学模型的Remdesivir：应用于SARS-COV-2的应用
- 作者：James M. Gallo
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
47.Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study

机译：氯喹和羟氯喹突入高于临床上用于治疗Covid-19的浓度的心律失常：模拟研究
- 作者：Jun‐ichi Okada;Takashi Yoshinaga;Takumi Washio;Kohei Sawada;Seiryo Sugiura;Toshiaki Hisada
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
48.Mortality viral clearance and other clinical outcomes of hydroxychloroquine in COVID‐19 patients: A systematic review and meta‐analysis of randomized controlled trials

机译：Covid-19患者中羟氯喹的死亡率病毒清除和其他临床结果：随机对照试验的系统审查和荟萃分析
- 作者：Zakariya Kashour;Tarek Kashour;Danielle Gerberi;Imad M. Tleyjeh
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
49.Approval success rates of drug candidates based on target action modality application and their combinations

机译：基于目标行动模态申请及其组合的批准毒品候选人的成功率
- 作者：Shingo Yamaguchi;Masayuki Kaneko;Mamoru Narukawa
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
50.Virtual screening FDA approved drugs against multiple targets of SARS‐CoV‐2

机译：虚拟筛选FDA批准了针对SARS-COV-2的多个目标的药物
- 作者：Hualou Liang;Liang Zhao;Xiajing Gong;Meng Hu;Hongbin Wang
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
51.Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

机译：应用CIPA方法评估在第一波Covid-19中使用的抗疟药的心律失常风险
- 作者：Annie Delaunois;Matthew Abernathy;Warren D. Anderson;Kylie A. Beattie;Khuram W. Chaudhary;Julie Coulot;Vitalina Gryshkova;Simon Hebeisen;Mark Holbrook;James Kramer;Yuri Kuryshev;Derek Leishman;Isabel Lushbough;Elisa Passini;Will S. Redfern;Blanca Rodriguez;Eric I. Rossman;Cristian Trovato;Caiyun Wu;Jean‐Pierre Valentin
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
52.Assessing the impact of COVID‐19 on registered interventional clinical trials

机译：评估Covid-19对注册介入临床试验的影响
- 作者：Nour Hawila;Arthur Berg
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
53.In vitro safety clinical trial of the cardiac liability of drug polytherapy

机译：体外安全临床试验药物多疗法的心脏责任
- 作者：Bérénice Charrez;Verena Charwat;Brian Siemons;Henrik Finsberg;Evan W. Miller;Andrew G. Edwards;Kevin E. Healy
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
54.Contextualizing single‐arm trials with real‐world data: An emulated target trial comparing therapies for neovascular age‐related macular degeneration

机译：具有真实世界数据的语境化单臂试验：模拟疗法与新生血管年龄相关性黄斑变性的疗法进行比较
- 作者：Darren S. Thomas;Aaron Y. Lee;Philipp L. Müller;Roy Schwartz;Abraham Olvera‐Barrios;Alasdair N. Warwick;Praven J. Patel;Tjebo F.C. Heeren;Catherine Egan;Paul Taylor;Adnan Tufail
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
55.Gene therapy for diabetic peripheral neuropathy: A randomized placebo‐controlled phase III study of VM202 a plasmid DNA encoding human hepatocyte growth factor

机译：糖尿病外周神经病变的基因治疗：VM202的随机安慰剂控制第三阶段研究一种编码人肝细胞生长因子的质粒DNA
- 作者：John A. Kessler;Aziz Shaibani;Christine N. Sang;Mark Christiansen;David Kudrow;Aaron Vinik;Nari Shin
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
56.Adherence to triple‐component antihypertensive regimens is higher with single‐pill than equivalent two‐pill regimens: A randomized controlled trial

机译：对三重组分的抗高血压方案的粘附性比同等的双丸方案的单丸更高：随机对照试验
- 作者：Jidong Sung;Kye Taek Ahn;Byung‐Ryul Cho;Sung Yun Lee;Byung Jin Kim;Dae Kyeong Kim;Joong‐il Park;Wang‐Soo Lee
- 期刊名称：《Clinical and Translational Science》 | 2021年第3期
57.Is this the end for ranitidine? NDMA presence continues to confound

机译：这是雷尼尼的结束吗？ NDMA存在继续混淆
- 作者：Jennifer A. Wagner;Jean C. Dinh;Jennifer R. Lightdale;Benjamin D. Gold;Jennifer M. Colombo
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
58.COVID‐19 vaccines and treatments: When speed is necessary and not enough

机译：Covid-19疫苗和治疗方法：当速度是必要的并且不够
- 作者：Thaddeus H. Grasela;David A. Price;John A. Wagner
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
59.Pharmacists as facilitators of pharmacogenomic guidance for antidepressant drug selection and dosing

机译：药剂师作为抗抑郁药物选择和给药的药物替补指导的促进者
- 作者：Jeffrey R. Bishop
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
60.Reimagining the peer‐review system for translational health science journals

机译：重新称解对平移健康科学期刊的同行评审系统
- 作者：Elise M. Smith
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
61.Evolving drug regulatory landscape in China: A clinical pharmacology perspective

机译：中国不断发展的药物监管景观：临床药理学观点
- 作者：Weifeng Tang;Ying Huang;Diansong Zhou;Yao Huang;Yingxue Chen;Song Ren;Yan Li;Shengqian Wu;Xiaoying Zhao;Xuyang Song;Haidong Wang;Yuwen Jin;Hongtao Yu;Li Zhang;Yunfei Li;David Boulton;Kevin Shen
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
62.Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments

机译：新生阿片类药物戒断综合征治疗的临床药理学与给药方案优化
- 作者：Fei Tang;Chee M. Ng;Henrietta S. Bada;Markos Leggas
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
63.Beyond exposure‐response: A tutorial on statistical considerations in dose‐ranging studies

机译：超越曝光 - 反应：剂量范围研究中的统计考虑教程
- 作者：Glen Laird;Lei Xu;Meng Liu;Jin Liu
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
64.Quantitative protein expression of blood‐brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer

机译：肺癌患者脑转移血管屏障转运蛋白的定量蛋白表达
- 作者：Xun Bao;Jianmei Wu;Jun Jiang;An‐Chi Tien;Nader Sanai;Jing Li
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
65.Safety Tolerability and Pharmacokinetics of Single and Repeat Doses of Vixotrigine in Healthy Volunteers

机译：在健康志愿者中单一的vixotrigine的单一和重复剂量的安全性耐受性和药代动力学
- 作者：Himanshu Naik;Deb J. Steiner;Mark Versavel;Joanne Palmer;Regan Fong
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
66.Pharmacokinetic equivalence of CT‐P17 to high‐concentration (100 mg/ml) reference adalimumab: A randomized phase I study in healthy subjects

机译：CT-P17的药代动力学当量至高浓度（100mg / mL）参考Adalimalab：我在健康受试者中研究的随机阶段
- 作者：Kyung‐Sang Yu;In‐Jin Jang;Hyeong‐Seok Lim;Jang Hee Hong;Min‐Gul Kim;Min Kyu Park;Doo‐Yeoun Cho;Min Soo Park;Jae Yong Chung;Jong‐Lyul Ghim;SeungHwan Lee;Seok Kyu Yoon;In Sun Kwon;Sang Joon Lee;Sung Hyun Kim;Yun Ju Bae;Jung Bin Cha;Daniel E. Furst;Edward Keystone;Jonathan Kay
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
67.Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities targeting CYP3A4*1G allele function

机译：CYP3A药物发生变化的表征美国印度和阿拉斯加本地社区靶向CYP3A4 * 1G等位基因功能
- 作者：Alison E. Fohner;Rachel Dalton;Kasse Skagen;Konner Jackson;Katrina G. Claw;Scarlett E. Hopkins;Renee Robinson;Burhan A. Khan;Bhagwat Prasad;Erin G. Schuetz;Deborah A. Nickerson;Timothy A. Thornton;Denise A. Dillard;Bert B. Boyer;Kenneth E. Thummel;Erica L. Woodahl
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
68.Evaluating risk factors for acute graft versus host disease in pediatric hematopoietic stem cell transplant patients receiving tacrolimus

机译：儿科造血干细胞移植患者急性移植物与宿主病的危险因素接受他克莫司
- 作者：Michael Phan;Rishikesh Chavan;Richard Beuttler;Nicole Benipayo;Grace Magedman;David Buchbinder;Daniel Tomaszewski;Sun Yang
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
69.First‐in‐human study of the safety tolerability pharmacokinetics and pharmacodynamics of ALPN‐101 a dual CD28/ICOS antagonist in healthy adult subjects

机译：在健康成人对象中ALPN-101的安全性耐受性药代动力学和AlPN-101的药效学和药效学的第一次人体研究
- 作者：Jing Yang;Jason D. Lickliter;Jan L. Hillson;Gary D. Means;Russell J. Sanderson;Kay Carley;Almudena Tercero;Kristi L. Manjarrez;Jennifer R. Wiley;Stanford L. Peng
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
70.Metabolomics analysis of the serum from children with urolithiasis using UPLC‐MS

机译：利用UPLC-MS对尿道病患儿童血清的代谢组科分析
- 作者：Junxiang Wen;Yinyin Cao;Yang Li;Fenhua Zhu;Meifen Yuan;Jin Xu;Jian Li
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
71.Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events

机译：预处理二氢嘧啶脱氢酶基因型引导氟哌米啶给药对化疗相关不良事件的影响
- 作者：Theodore J. Wigle;Brandi L. Povitz;Samantha Medwid;Wendy A. Teft;Robin M. Legan;John Lenehan;Stephanie Nevison;Veera Panuganty;Denise Keller;Jaymie Mailloux;Victoria Siebring;Sisira Sarma;Yun‐hee Choi;Stephen Welch;Eric Winquist;Ute I. Schwarz;Richard B. Kim
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
72.Estimating peptide half‐life in serum from tunable sequence‐related physicochemical properties

机译：从可调谐序列相关的物理化学性质估算血清中的肽半衰期
- 作者：Marco Cavaco;Javier Valle;Isabel Flores;David Andreu;Miguel A. R. B. Castanho
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
73.Pharmacogenomics guided versus standard antidepressant treatment in a community pharmacy setting: A randomized controlled trial

机译：药替昔炎在社区药房环境中导致标准抗抑郁药物：随机对照试验
- 作者：John Papastergiou;Lena C. Quilty;Wilson Li;Thulasi Thiruchselvam;Esha Jain;Peter Gove;Leilany Mandlsohn;Bart van den Bemt;Nedzad Pojskic
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
74.Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

机译：人肝细胞的脂质液滴筛网将TRRAP鉴定为细胞甘油三酯代谢的调节剂
- 作者：Deepti Abbey;Donna Conlon;Christopher Rainville;Susannah Elwyn;Katherine Quiroz‐Figueroa;Jeffrey Billheimer;David C. Schultz;Nicholas J. Hand;Sara Cherry;Daniel J. Rader
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
75.Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

机译：羧基酯酶1遗传多态性对健康志愿者中肝腹部曲线肺泡活化的影响及药代动力学及药效学
- 作者：Xinwen Wang;Lucy Her;Jingcheng Xiao;Jian Shi;Audrey H. Wu;Barry E. Bleske;Hao‐Jie Zhu
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
76.Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto’s thyroiditis: A prospective randomized‐controlled trial

机译：硒对血小板甲状腺炎患者甲状腺自身免疫和监管T细胞的影响：预期随机对照试验
- 作者：Yifang Hu;Wenwen Feng;Huanhuan Chen;He Shi;Lin Jiang;Xuqin Zheng;Xiaoyun Liu;Wensong Zhang;Yaoqi Ge;Yun Liu;Dai Cui
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
77.Relationship of hemoglobin level and plasma coproporphyrin‐I concentrations as an endogenous probe for phenotyping OATP1B

机译：血红蛋白水平和血浆豆蔻卟啉-i浓度作为表型oatp1b的内源探针的关系
- 作者：Yosuke Suzuki;Yuri Sasamoto;Teruhide Koyama;Chisato Yoshijima;Ayako Oda;Masahiro Nakatochi;Michiaki Kubo;Yukihide Momozawa;Ritei Uehara;Keiko Ohno
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
78.A retrospective analysis of actionable pharmacogenetic/genomic biomarker language in FDA labels

机译：FDA标签中可行的药物发生/基因组生物标志物语言的回顾性分析
- 作者：Shinji Yamazaki
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
79.A randomized double‐blind placebo‐ and positive‐controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects

机译：随机双盲安慰剂安慰剂安慰剂和正控制的交叉分流对健康受试者心脏再渗色的影响
- 作者：John O’Donnell;Kathleen Maloney;Melissa Steidler;Royce Morrison;Robin Isaacs
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
80.Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics

机译：健康志愿者中的氧基林醇药代动力学和药效学：BCRP Q141K多态性和患者特征的影响
- 作者：Bianca Vora;Deanna J. Brackman;Ling Zou;Maria Garcia‐Cremades;Marina Sirota;Radojka M. Savic;Kathleen M. Giacomini
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
81.Integrating real‐world data and modeling to project changes in femoral neck bone mineral density and fracture risk in premenopausal women

机译：将现实世界数据与建模整合到股骨颈骨密度和骨折骨折骨折骨折的骨折风险
- 作者：Denise Beck;Insa Winzenborg;Wei Gao;Nael M. Mostafa;Peter Noertersheuser;Stephanie E. Chiuve;Charlotte Owens;Mohamad Shebley
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
82.Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease

机译：在健康受试者和帕金森病的患者中血管甲肽舌下胶片或皮下翼柳胺的人口药代动力学分析
- 作者：Felix Agbo;Ryan L. Crass;Yu‐Yuan Chiu;Sunny Chapel;Gerald Galluppi;David Blum;Bradford Navia
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
83.A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose

机译：对乙酰氨基酚overdose患者标准和改性N-乙酰半胱氨酸处理方案的硫醇反应的代谢分析
- 作者：James W Dear;Mei Li Ng;D. Nicholas Bateman;Pakkiri Leroy Sivappiragasam;Hyungwon Choi;Benjamin Bing Jie Khoo;Baharudin Ibrahim;Chester Lee Drum
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
84.Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

机译：鉴定致血管内诱导的神经毒性的小分子同时使白血病细胞敏感到血管内
- 作者：Barthelemy Diouf;Claudia Wing;John C. Panetta;Donnie Eddins;Wenwei Lin;Wenjian Yang;Yiping Fan;Deqing Pei;Cheng Cheng;Shannon M. Delaney;Wei Zhang;Erik J. Bonten;Kristine R. Crews;Steven W. Paugh;Lie Li;Burgess B. Freeman 3rd;Robert J. Autry;Jordan A. Beard;Daniel C. Ferguson;Laura J. Janke;Kirsten K. Ness;Taosheng Chen;Stanislav S. Zakharenko;Sima Jeha;Ching‐Hon Pui;Mary V. Relling;M. Eileen Dolan;William E. Evans
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
85.Pharmacokinetics and tolerability of apremilast in healthy Korean adult men

机译：健康韩国成人男子的药代动力学和耐受性
- 作者：Ki Young Huh;Yewon Choi;Jim Nissel;Maria Palmisano;Xiaomin Wang;Liangang Liu;Francisco Ramirez‐Valle;Howard Lee
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
86.Safety tolerability pharmacokinetics and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

机译：TLR7激动剂前药RO6870868在健康志愿者中的安全性耐受性药代动力学和药效学
- 作者：Joseph F. Grippo;Ilia Folitar;Sharon Passe;Qiudi Jiang;Ignacio Rodriguez;Scott H. Fettner;Elizabeth Calleja
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
87.Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP OATP1B1 and OAT3 transporters

机译：监管指南不准确地预测BCRPOATP1B1和OAT3运输司机的托尔瓦普坦和代谢物相互作用
- 作者：Susan E. Shoaf;Patricia Bricmont;Jennifer Repella Gordon
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
88.Model‐based approach to sampling optimization in studies of antibacterial drugs for infants and young children

机译：基于模型的婴幼儿抗菌药物的采样优化方法
- 作者：Yuji Orito;Makoto Kakara;Akira Okada;Naomi Nagai
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
89.A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation

机译：用于在程序镇静中与芬太尼共同施用芬太尼时测定Remimazolam诱导镇静的群体药效动物Markov混合效应模型
- 作者：Jie Zhou;Laura Curd;Lauren R. L. Lohmer;Natalie Delpratt;Joachim Ossig;Frank Schippers;Thomas Stoehr;Virginia D. Schmith
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
90.Associations between uncertainties identified by the European Medicines Agency and national decision making on reimbursement by HTA agencies

机译：欧洲药品局鉴定的不确定性与HTA机构报销报销的不确定性之间的协会
- 作者：Lourens T. Bloem;Rick A. Vreman;Niels W. L. Peeters;Jarno Hoekman;Menno E. van der Elst;Hubert G. M. Leufkens;Olaf H. Klungel;Wim G. Goettsch;Aukje K. Mantel‐Teeuwisse
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
91.Diagnostic and prognostic capabilities of a biomarker and EMR‐based machine learning algorithm for sepsis

机译：脓毒症生物标志物和基于EMR的机器学习算法的诊断和预后能力
- 作者：Ishan Taneja;Gregory L. Damhorst;Carlos Lopez‐Espina;Sihai Dave Zhao;Ruoqing Zhu;Shah Khan;Karen White;James Kumar;Andrew Vincent;Leon Yeh;Shirin Majdizadeh;William Weir;Scott Isbell;James Skinner;Manubolo Devanand;Syed Azharuddin;Rajamurugan Meenakshisundaram;Riddhi Upadhyay;Anwaruddin Syed;Thomas Bauman;Joseph Devito;Charles Heinzmann;Gregory Podolej;Lanxin Shen;Sanjay Sharma Timilsina;Lucas Quinlan;Setareh Manafirasi;Enrique Valera;Bobby Reddy Jr.;Rashid Bashir
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
92.First‐in‐human trial assessing the pharmacokinetic‐pharmacodynamic profile of a novel recombinant human chorionic gonadotropin in healthy women and men of reproductive age

机译：第一载于人体试验评估新型重组人绒毛膜促性腺药物的药代动力学药物动力学概况在健康妇女和生殖年龄的男性中
- 作者：Lars‐Erik Broksø Kyhl;Christiane Hesse;Per Larsson;Katharina Bruzelius;Bernadette Mannaerts
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
93.Comprehensive in vitro pro‐arrhythmic assays demonstrate that omecamtiv mecarbil has low pro‐arrhythmic risk

机译：综合体外促心律程验测定表明OMecamtiv Mecarbil具有低的亲心律失常风险
- 作者：Yusheng Qu;BaoXi Gao;Ziva Arimura;Mei Fang;Hugo M. Vargas
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期
94.Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis

机译：用子宫内膜异位症妇女的Elagolix第3期临床试验数据验证钙稳态的定量系统药理模型
- 作者：Sven Stodtmann;Ahmed Nader;Akshanth R. Polepally;Ahmed A. Suleiman;Insa Winzenborg;Peter Noertersheuser;Juki Ng;Nael M. Mostafa;Mohamad Shebley
- 期刊名称：《Clinical and Translational Science》 | 2021年第4期