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Protein Engineering, Design and Selection

【机译】：蛋白质工程，设计选型

ISSN：-
出版周期：Monthly
语言：English

起始发布年份：2004
出版者：Oxford, UK : Oxford University Press, c2003-
出版地：England

NLM刊名缩写：Protein Eng Des Sel

数据库引入：

MeSH词表主题词：Protein Engineering*

备注：Title from cover. Also available online.展开▼

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1.Seeking allosteric networks in PDZ domains

机译：在PDZ域中寻找变构网络
- 作者：Candice Gautier;Louise Laursen;Per Jemth;Stefano Gianni
- 期刊名称：《Protein Engineering, Design and Selection》
- allostery conformational changes peptide binding protein–protein interaction;
2.Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold

机译：蛋白质折叠的不可预测的可塑性促进了工程配体结合蛋白的意外特异性
- 作者：Austin L Day;Per Greisen;Lindsey Doyle;Alberto Schena;Nephi Stella;Kai Johnsson;David Baker;Barry Stoddard
- 期刊名称：《Protein Engineering, Design and Selection》
- affinity versus specificity crystal structure ligand binding protein engineering;
3.An adaptive geometric search algorithm for macromolecular scaffold selection

机译：高分子支架选择的自适应几何搜索算法
- 作者：Tian Jiang;P Douglas Renfrew;Kevin Drew;Noah Youngs;Glenn L Butterfoss;Richard Bonneau;Den Nis Shasha
- 期刊名称：《Protein Engineering, Design and Selection》
- enzyme design foldamer loop modeling metal binding octree;
4.Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

机译：可变重可变轻域和带电荷残基交换的Fab臂CrossMab以强制正确的轻链组装
- 作者：Joerg Thomas Regula;Sabine Imhof-Jung;Michael Mølhøj;Joerg Benz;Andreas Ehler;Alexander Bujotzek;Wolfgang Schaefer;Christian Klein
- 期刊名称：《Protein Engineering, Design and Selection》
- Angiopoietin-2 bispecific antibody CrossMab VEGF;
5.Molecular dynamics-derived rotamer libraries for d-amino acids within homochiral and heterochiral polypeptides

机译：分子动力学衍生的同构手性和杂手性多肽中d-氨基酸的旋转异构体文库
- 作者：Matthew Carter Childers;Clare-Louise Towse;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- computational protein design conformational analysis d-amino acids intrinsic propensities molecular dynamics simulation rotamer library;
6.Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen

机译：迈向第四级HIV-1表位的构象保真度：最小V1V2抗原的计算设计和定向进化
- 作者：Jennifer I Lai;Deeptak Verma;Chris Bailey-Kellogg;Margaret E Ackerman
- 期刊名称：《Protein Engineering, Design and Selection》
- computational protein design directed evolution epitope-focusing HIV-1 structure-based vaccine design;
7.Identification of high affinity HER2 binding antibodies using CHO Fab surface display

机译：使用CHO Fab表面展示鉴定高亲和力HER2结合抗体
- 作者：Annalee W Nguyen;Kevin C Le;Jennifer A Maynard
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody engineering expression engineering hu4D5 mammalian display Trastuzumab;
8.A new method for post-translationally labeling proteins in live cells forfluorescence imaging and tracking

机译：一种翻译后标记活细胞中蛋白质的新方法荧光成像和跟踪
- 作者：M Hinrichsen;M Lenz;J M Edwards;O K Miller;S G J Mochrie;P S Swain;U Schwarz-Linek;L Regan
- 期刊名称：《Protein Engineering, Design and Selection》
- membrane protein protein engineering S. cerevisiae single cell SpyCatcher-SpyTag;
9.Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator

机译：替代Yor1p NBD1残基可改善人囊性纤维化跨膜电导调节剂的热稳定性
- 作者：B M Xavier;E Hildebrandt;F Jiang;H Ding;J C Kappes;I L Urbatsch
- 期刊名称：《Protein Engineering, Design and Selection》
- ABC transporter chimera CFTR nucleotide-binding domains stabilizing mutations thermal stability;
10.A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family

机译：一组选择性识别和拮抗干扰素α家族成员的合成抗体
- 作者：S Miersch;S Kuruganti;M R Walter;S S Sidhu
- 期刊名称：《Protein Engineering, Design and Selection》
- antagonist antibody engineering cytokine interferon alpha interferon signaling phage display;
11.Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display

机译：通过酵母展示筛选亲和力成熟的人硫酸软骨素蛋白聚糖4抗体片段
- 作者：Xin Yu;Liang Qu;Darell D Bigner;Vidyalakshmi Chandramohan
- 期刊名称：《Protein Engineering, Design and Selection》
- affinity maturation CSPG4 random mutagenesis scFv yeast display;
12.Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening

机译：拴系可变CL双特异性IgG：快速双特异性抗体筛选的抗体平台
- 作者：Hok Seon Kim;Diana Ronai Dunshee;Angie Yee;Raymond K Tong;Ingrid Kim;Farzam Farahi;Jo-Anne Hongo;James A Ernst;Junichiro Sonoda;Christoph Spiess
- 期刊名称：《Protein Engineering, Design and Selection》
- biepitopic antibody bispecific antibody FGF21 FGFR1 high throughput screening KLB therapeutic mAb;
13.Quercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant

机译：槲皮素和槲皮素3-β-d-葡萄糖苷作为引起A4V SOD1 ALS突变体的化学分子伴侣
- 作者：Philbert Ip;Priya Roy Sharda;Anna Cunningham;Sumon Chakrabartty;Vijay Pande;Avijit Chakrabartty
- 期刊名称：《Protein Engineering, Design and Selection》
- amyotrophic lateral sclerosis chemical chaperones CuZn superoxide dismutase native-state stabilizers protein misfolding;
14.Modulating and evaluating receptor promiscuity through directed evolution and modeling

机译：通过定向进化和建模来调节和评估受体的混杂
- 作者：Sarah C. Stainbrook;Jessica S. Yu;Michael P. Reddick;Neda Bagheri;Keith E. J. Tyo
- 期刊名称：《Protein Engineering, Design and Selection》
- directed evolution partial least squares regression (PLSR) receptor promiscuity;
15.Engineering a high-affinity peptide binding site into the anti-CEA mAb M5A

机译：将高亲和力肽结合位点工程化到抗CEA mAb M5A中
- 作者：Cindy Zer;Kendra N. Avery;Kassondra Meyer;Leah Goodstein;Krzysztof P. Bzymek;Gagandeep Singh;John C. Williams
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody-drug conjugate antibody engineering CEA grafting meditope;
16.Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633 a member of the Class 3 aldehyde dehydrogenase superfamily

机译：3类乙醛脱氢酶超家族成员恶臭假单胞菌ATCC 12633的苯甲醛脱氢酶的结构和机理
- 作者：Megan P.D. Zahniser;Shreenath Prasad;Malea M. Kneen;Cheryl A. Kreinbring;Gregory A. Petsko;Dagmar Ringe;Michael J. McLeish
- 期刊名称：《Protein Engineering, Design and Selection》
- hydride transfer isotope effect mutagenesis NAD(P)sup+/sup X-ray;
17.Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase

机译：从单纯疱疹病毒胸苷激酶开发癌症标志物激活的酶促开关
- 作者：Nirav Y. Shelat;Sidhartha Parhi;Marc Ostermeier
- 期刊名称：《Protein Engineering, Design and Selection》
- directed evolution herpes simplex virus thymidine kinase HSV protein switch thymidine kinase;
18.Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus

机译：噬菌体展示肽库的深度测序揭示了检测诺如病毒的序列基序
- 作者：Amy M. Hurwitz;Wanzhi Huang;Mary K. Estes;Robert L. Atmar;Timothy Palzkill
- 期刊名称：《Protein Engineering, Design and Selection》
- diagnostics informatics norovirus peptide phage display;
19.Dual chemistry catalyzed by human acireductone dioxygenase

机译：人a啶酮双加氧酶催化的双重化学反应
- 作者：Aditi R. Deshpande;Thomas C. Pochapsky;Gregory A. Petsko;Dagmar Ringe
- 期刊名称：《Protein Engineering, Design and Selection》
- acireductone dual chemistry Klebsiella oxytoca mammalian metal;
20.Allosteric control of antibody-prion recognition through oxidation of a disulfide bond between the CH and CL chains

机译：通过CH和CL链之间的二硫键氧化来对抗体-pr病毒识别进行变构控制
- 作者：Jun Zhao;Ruth Nussinov;Buyong Ma
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody–antigen interaction bound water molecules community analysis disulfide bond dynamic network motion correlation;
21.Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation

机译：工程化最少的G蛋白以促进G蛋白偶联受体的活性构象结晶
- 作者：Byron Carpenter;Christopher G. Tate
- 期刊名称：《Protein Engineering, Design and Selection》
- complex G protein G protein-coupled receptor GPCR Gs mini G protein mini-Gs;
22.A deimmunised form of the ribotoxin α-sarcin lacking CD4+ T cell epitopes and its use as an immunotoxin warhead

机译：缺乏CD4 + T细胞表位的核糖毒素α-sarcin的去免疫形式及其作为免疫毒素弹头的用途
- 作者：Tim D. Jones;Arron R. Hearn;Robert G.E. Holgate;Dorota Kozub;Mark H. Fogg;Francis J. Carr;Matthew P. Baker;Javier Lacadena;Kurt R. Gehlsen
- 期刊名称：《Protein Engineering, Design and Selection》
- α-sarcin deimmunisation immunogenicity immunotoxin T cell epitope;
23.Revisiting antibody modeling assessment for CDR-H3 loop

机译：回顾CDR-H3环的抗体建模评估
- 作者：Hiroshi Nishigami;Narutoshi Kamiya;Haruki Nakamura
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody CDR-H3 loop multicanonical molecular dynamics simulation free energy landscape crystal packing;
24.TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations

机译：TetraMabs：同时靶向四种致癌受体酪氨酸激酶以抑制异种肿瘤细胞群体中的肿瘤生长
- 作者：Raffaella Castoldi;Jürgen Schanzer;Christian Panke;Ute Jucknischke;Natalie J. Neubert;Rebecca Croasdale;Werner Scheuer;Johannes Auer;Christian Klein;Gerhard Niederfellner;Sebastian Kobold;Claudio Sustmann
- 期刊名称：《Protein Engineering, Design and Selection》
- cancer cMet EGFR HER3 IGF1R receptor tyrosine kinase tetraspecific antibody therapeutic antibody;
25.Improved prediction of antibody VL–VH orientation

机译：改善了抗体VL–VH方向的预测
- 作者：Nicholas A. Marze;Sergey Lyskov;Jeffrey J. Gray
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody modeling antibody structure computational structure prediction domain orientation;
26.Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12

机译：小鼠白介素12 p40亚基融合蛋白糖基化变异体的不同组织分布特性
- 作者：F. Bootz;D. Venetz;B. Ziffels;D. Neri
- 期刊名称：《Protein Engineering, Design and Selection》
- biodistribution glycoproteins F8 antibody immunocytokines;
27.An in silico algorithm for identifying stabilizingpockets in proteins: test case the Y220C mutant of the p53 tumor suppressorprotein

机译：一种用于识别稳定度的计算机模拟算法蛋白质中的口袋：测试用例p53抑癌药的Y220C突变体蛋白
- 作者：Dennis Bromley;Matthias R. Bauer;Alan R. Fersht;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- cancer docking drug design ligand pharmacophore small-molecule visual analytics;
28.Probing the minimal determinants of zinc binding with computational protein design

机译：用计算蛋白质设计探索锌结合的最小决定因素
- 作者：Sharon L. Guffy;Bryan S. Der;Brian Kuhlman
- 期刊名称：《Protein Engineering, Design and Selection》
- metalloproteins protein design Rosetta zinc binding;
29.Influenza evolution and H3N2 vaccine effectiveness with application to the 2014/2015 season

机译：流感演变和H3N2疫苗有效性应用于2014/2015赛季
- 作者：Xi Li;Michael W. Deem
- 期刊名称：《Protein Engineering, Design and Selection》
- dominant strains influenza evolution pepitope phylogeny vaccine effectiveness;
30.The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design

机译：手性和位阻对内在骨架构象倾向的影响：蛋白质设计工具
- 作者：Matthew Carter Childers;Clare-Louise Towse;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- chirality conformational propensity denatured state host–guest series intrinsic propensity molecular dynamics simulation;
31.Transthyretin variants with improved inhibition of β-amyloid aggregation

机译：转甲状腺素蛋白变体具有更好的β-淀粉样蛋白聚集抑制作用
- 作者：Parth Mangrolia;Dennis T. Yang;Regina M. Murphy
- 期刊名称：《Protein Engineering, Design and Selection》
- amyloid protein aggregation transthyretin;
32.Structural features determining thermal adaptation of esterases

机译：决定酯酶热适应性的结构特征
- 作者：Filip Kovacic;Agathe Mandrysch;Chetan Poojari;Birgit Strodel;Karl-Erich Jaeger
- 期刊名称：《Protein Engineering, Design and Selection》
- esterase molecular dynamics psychrophilic psychrotrophic mesophilic thermophilic bacteria thermophilicity thermostability;
33.Modular protein switches derived from antibody mimetic proteins

机译：源自抗体模拟蛋白的模块化蛋白开关
- 作者：N. Nicholes;A. Date;P. Beaujean;P. Hauk;M. Kanwar;M. Ostermeier
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody mimetic proteins DARPins monobodies protein switches;
34.Directed evolution of human scFvs in DT40 cells

机译：人scFv在DT40细胞中的定向进化
- 作者：Alfred W.Y. Lim;Gareth T. Williams;Cristina Rada;Julian E. Sale
- 期刊名称：《Protein Engineering, Design and Selection》
- affinity maturation in vitro selection monoclonal antibodies scFv somatic hypermutation;
35.Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

机译：通过基于结构的设计和噬菌体展示工程化KEAP1-NRF2相互作用的遗传编码竞争性抑制剂
- 作者：Gurkan Guntas;Steven M. Lewis;Kathleen M. Mulvaney;Erica W. Cloer;Ashutosh Tripathy;Thomas R. Lane;Michael B. Major;Brian Kuhlman
- 期刊名称：《Protein Engineering, Design and Selection》
- KEAP1 NRF2 protein design redox regulation Rosetta molecular modeling program;
36.Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies

机译：嫁接的淀粉样蛋白基序域抗体的亲和力和稳定性的共同进化
- 作者：Mark C. Julian;Christine C. Lee;Kathryn E. Tiller;Lilia A. Rabia;Evan K. Day;Arthur J. Schick III;Peter M. Tessier
- 期刊名称：《Protein Engineering, Design and Selection》
- CDR directed evolution scFv VH yeast surface display;
37.A switchable yeast display/secretion system

机译：可切换的酵母展示/分泌系统
- 作者：James A. Van Deventer;Ryan L. Kelly;Saravanan Rajan;K. Dane Wittrup;Sachdev S. Sidhu
- 期刊名称：《Protein Engineering, Design and Selection》
- amber suppression antibody screening phage display synthetic antibody library yeast display;
38.Increased Fab thermoresistance via VH-targeted directed evolution

机译：通过VH定向进化提高Fab热阻
- 作者：Kevin C. Entzminger;Jennifer L. Johnson;Jeongmin Hyun;Raquel L. Lieberman;Jennifer A. Maynard
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody engineering directed evolution phage display protein expression protein stability;
39.Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity

机译：梭菌醇脱氢酶辅因子磷酸结合位点的取代导致底物特异性的意外变化
- 作者：Danielle J. Maddock;Wayne M. Patrick;Monica L. Gerth
- 期刊名称：《Protein Engineering, Design and Selection》
- alcohol dehydrogenase Clostridium autoethanogenum cofactor specificity enzyme engineering mutagenesis;
40.Studying protein fold evolution with hybrids of differently folded homologs

机译：用不同折叠同源物的杂种研究蛋白质折叠进化
- 作者：Karen V. Eaton;William J. Anderson;Matthew S. Dubrava;Vlad K. Kumirov;Emily M. Dykstra;Matthew H. J. Cordes
- 期刊名称：《Protein Engineering, Design and Selection》
- chimera folding specificity hybrid sequence structural evolution;
41.Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis

机译：通过shot弹枪蛋白水解源自膜蛋白的可溶性片段的溶液结构
- 作者：Mark D. Allen;Mary Christie;Peter Jones;Benjamin T. Porebski;Brendan Roome;Stefan M.V. Freund;Ashley M. Buckle;Mark Bycroft;Daniel Christ
- 期刊名称：《Protein Engineering, Design and Selection》
- membrane proteins NMR spectroscopy phage display protein domains proteolysis;
42.Cytokine refacing effect reduces granulocyte macrophage colony-stimulating factor susceptibility to antibody neutralization

机译：细胞因子的表面置换作用降低了粒细胞巨噬细胞集落刺激因子对抗体中和的敏感性
- 作者：Pete Heinzelman;Sharon J. Carlson;George N. Cox
- 期刊名称：《Protein Engineering, Design and Selection》
- Alzheimers disease Crohns disease GM-CSF immunogenicity irritable bowel syndrome;
43.Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide

机译：半合成双环肽的亚基拆卸和抑制TNFα
- 作者：Stefan Luzi;Yasushi Kondo;Elise Bernard;Lukas K. J. Stadler;Marina Vaysburd;Greg Winter;Philipp Holliger
- 期刊名称：《Protein Engineering, Design and Selection》
- bicyclic peptide phage display protein engineering TNF;
44.Alteration of substrate specificity of alanine dehydrogenase

机译：丙氨酸脱氢酶底物特异性的改变
- 作者：Puja Fernandes;Hannah Aldeborgh;Lauren Carlucci;Lauren Walsh;Jordan Wasserman;Edward Zhou;Scott T. Lefurgy;Emily C. Mundorff
- 期刊名称：《Protein Engineering, Design and Selection》
- alanine dehydrogenase amino acid dehydrogenase evolvability saturation mutagenesis superfamily;
45.Engineering the respiratory membrane-bound hydrogenase of the hyperthermophilic archaeon Pyrococcus furiosus and characterization of the catalytically active cytoplasmic subcomplex

机译：工程化嗜热古细菌激烈热球菌的呼吸膜结合氢酶和催化活性胞质亚复合体的表征。
- 作者：Patrick M. McTernan;Sanjeev K. Chandrayan;Chang-Hao Wu;Brian J. Vaccaro;W. Andrew Lancaster;Michael W. W. Adams
- 期刊名称：《Protein Engineering, Design and Selection》
- Hydrogenase Membrane protein Differential expression Archaea;
46.Design and characterization of structured protein linkers with differing flexibilities

机译：具有不同灵活性的结构化蛋白质接头的设计和表征
- 作者：Joshua S. Klein;Siduo Jiang;Rachel P. Galimidi;Jennifer R. Keeffe;Pamela J. Bjorkman
- 期刊名称：《Protein Engineering, Design and Selection》
- fusion proteins hydrodynamic radius linker design size-exclusion chromatography;
47.Nature versus design: the conformational propensities of d-amino acids and the importance of side chain chirality

机译：自然与设计：d-氨基酸的构象倾向和侧链手性的重要性
- 作者：Clare-Louise Towse;Gene Hopping;Ivan Vulovic;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- conformational sampling d-amino acids epimerization MD simulation racemization;
48.SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected synthetic protein libraries for directed evolution

机译：SpeedyGenes：一种改进的基因合成方法可有效产生经纠错的合成蛋白质库用于定向进化
- 作者：Andrew Currin;Neil Swainston;Philip J. Day;Douglas B. Kell
- 期刊名称：《Protein Engineering, Design and Selection》
- directed evolution error correction gene synthesis protein libraries;
49.Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells

机译：第二代人抗ErbB2免疫RNA酶对曲妥珠单抗耐药的肿瘤和心脏细胞的影响
- 作者：Chiara DAvino;Rolando Paciello;Gennaro Riccio;Melina Coppola;Paolo Laccetti;Nicola Maurea;Ronald T. Raines;Claudia De Lorenzo
- 期刊名称：《Protein Engineering, Design and Selection》
50.An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network

机译：一种改进的蛋白质G其通过计算设计的极性网络对人/兔IgG Fc域具有更高的亲和力
- 作者：Ramesh K. Jha;Tiziano Gaiotto;Andrew R.M. Bradbury;Charlie E.M. Strauss
- 期刊名称：《Protein Engineering, Design and Selection》
- Computational protein design Fc domain Immunoglobulin G Polar interaction Protein G;
51.In vitro Fab display: a cell-free system for IgG discovery

机译：体外Fab展示：用于发现IgG的无细胞系统
- 作者：Ryan L. Stafford;Marissa L. Matsumoto;Gang Yin;Qi Cai;Juan Jose Fung;Heather Stephenson;Avinash Gill;Monica You;Shwu-Hwa Lin;Willie D. Wang;Mary Rose Masikat;Xiaofan Li;Kalyani Penta;Alex R. Steiner;Ramesh Baliga;Christopher J. Murray;Christopher D. Thanos;Trevor J. Hallam;Aaron K. Sato
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody reformatting cell-free protein synthesis Fab selections ribosome display;
52.Quantification of cell surface proteins with bispecific antibodies

机译：用双特异性抗体定量细胞表面蛋白
- 作者：C. Panke;D. Weininger;A. Haas;F. Schelter;T. Schlothauer;S. Bader;R. Sircar;H.P. Josel;U. Baer;H. Burtscher;O. Mundigl;M. Grote;U. Brinkmann;C. Sustmann
- 期刊名称：《Protein Engineering, Design and Selection》
- bispecific antibodies cMET digoxigenin ErbB receptor quantification;
53.Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons

机译：真菌P450单加氧酶CYP5136A3的合理工程设计以提高其对多环芳烃的氧化活性
- 作者：Khajamohiddin Syed;Aleksey Porollo;David Miller;Jagjit S. Yadav
- 期刊名称：《Protein Engineering, Design and Selection》
- biocatalyst cytochrome P450 monooxygenase Phanerochaete chrysosporium polycyclic aromatic hydrocarbon protein engineering;
54.Isolation of αL I domain mutants mediating firm cell adhesion using a novel flow-based sorting method

机译：使用新型基于流的分选方法分离介导牢固细胞粘附的αLI域突变体
- 作者：Lauren R. Pepper;Ranganath Parthasarathy;Gregory P. Robbins;Nicholas N. Dang;Daniel A. Hammer;Eric T. Boder
- 期刊名称：《Protein Engineering, Design and Selection》
- αL integrin conformational regulation I domain rolling adhesion yeast display;
55.Design and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation

机译：用于核糖体翻译研究的高效tRNA：EF-Tu FRET系统的设计和性质
- 作者：Maxim Chudaev;Kiran Poruri;Emanuel Goldman;Hieronim Jakubowski;Mohit Raja Jain;Wei Chen;Hong Li;Sanjay Tyagi;Wlodek Mandecki
- 期刊名称：《Protein Engineering, Design and Selection》
- elongation factor Tu transfer RNA fluorescence resonance energy transfer ternary complex;
56.A structural bioinformatics approach for identifying proteins predisposed to bind linear epitopes on pre-selected target proteins

机译：一种结构生物信息学方法用于鉴定易于结合预选靶蛋白上线性表位的蛋白
- 作者：Eun Jung Choi;Ron Jacak;Brian Kuhlman
- 期刊名称：《Protein Engineering, Design and Selection》
- epitope protein engineering protein–protein interaction protein scaffold structural bioinformatics;
57.A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor

机译：一种新型的抗RNase抑制剂的完全人类抗肿瘤ImmunoRNase
- 作者：Gennaro Riccio;Chiara DAvino;Ronald T. Raines;Claudia De Lorenzo
- 期刊名称：《Protein Engineering, Design and Selection》
- breast cancer ErbB2 human RNase immunotherapy RNase inhibitor;
58.Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

机译：结合功能受限的双特异性抗体衍生物可通过蛋白水解过程激活
- 作者：Silke Metz;Christian Panke;Alexander K. Haas;Jürgen Schanzer;Wilma Lau;Rebecca Croasdale;Eike Hoffmann;Britta Schneider;Johannes Auer;Christian Gassner;Birgit Bossenmaier;Pablo Umana;Claudio Sustmann;Ulrich Brinkmann
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody engineering bispecific antibodies disulfide stabilization protease activation;
59.Improved drug-like properties of therapeutic proteins by directed evolution

机译：通过定向进化改善治疗性蛋白质的类药物特性
- 作者：Andrew Buchanan;Franco Ferraro;Steven Rust;Sudharsan Sridharan;Ruth Franks;Greg Dean;Matthew McCourt;Lutz Jermutus;Ralph Minter
- 期刊名称：《Protein Engineering, Design and Selection》
- developability directed evolution expression ribosome display stability;
60.Molecular characterization of novel trispecificErbB-cMet-IGF1R antibodies and theirantigen-binding properties

机译：新型三特异性分子的分子表征ErbB-cMet-IGF1R抗体及其抗原结合特性
- 作者：R. Castoldi;U. Jucknischke;L.P. Pradel;E. Arnold;C. Klein;S. Scheiblich;G. Niederfellner;C. Sustmann
- 期刊名称：《Protein Engineering, Design and Selection》
- ITC receptor tyrosine kinase SPR therapeutic antibodies trispecific antibodies;
61.Design and analysis of immune-evading enzymes for ADEPT therapy

机译：ADEPT疗法的免疫逃避酶的设计与分析
- 作者：Daniel C. Osipovitch;Andrew S. Parker;Christabell D. Makokha;Joseph Desrosiers;Warren C. Kett;Leonard Moise;Chris Bailey-Kellogg;Karl E. Griswold
- 期刊名称：《Protein Engineering, Design and Selection》
- ADEPT computational protein design deimmunization T-cell epitope therapeutic protein;
62.An enhanced approach for engineering thermally stable proteins using yeast display

机译：使用酵母展示工程热稳定蛋白的增强方法
- 作者：Tej V. Pavoor;Jean A. Wheasler;Viraj Kamat;Eric V. Shusta
- 期刊名称：《Protein Engineering, Design and Selection》
- protein engineering thermal stability yeast surface display;
63.Computer-aided antibody design

机译：计算机辅助抗体设计
- 作者：Daisuke Kuroda;Hiroki Shirai;Matthew P. Jacobson;Haruki Nakamura
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody design antibody engineering protein therapeutics vaccine design;
64.Disruption of the X-loop turn of the prion protein linked to scrapie resistance

机译：与瘙痒病抗性有关的the病毒蛋白X环转向的破坏
- 作者：Alexander D. Scouras;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- prion disease resistance to disease species barrier X-loop;
65.Landscape phages and their fusion proteins targeted to breast cancer cells

机译：针对乳腺癌细胞的景观噬菌体及其融合蛋白
- 作者：Olusegun A. Fagbohun;Deepa Bedi;Natalia I. Grabchenko;Patricia A. Deinnocentes;Richard C. Bird;Valery A. Petrenko
- 期刊名称：《Protein Engineering, Design and Selection》
- breast cancer landscape phage nucleolin phage display phage library;
66.A method for multi-codon scanning mutagenesis of proteins based on asymmetric transposons

机译：基于不对称转座子的蛋白质多密码子扫描诱变方法
- 作者：Jia Liu;T.Ashton Cropp
- 期刊名称：《Protein Engineering, Design and Selection》
- codon mutagenesis directed evolution transposon;
67.Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications

机译：用于质谱分析的CFTR的纯化：棕榈酰化和其他翻译后修饰的鉴定
- 作者：Michelle McClure;Lawrence J. DeLucas;Landon Wilson;Marjorie Ray;Steven M. Rowe;Xiaoyun Wu;Qun Dai;Jeong S. Hong;Eric J. Sorscher;John C. Kappes;Stephen Barnes
- 期刊名称：《Protein Engineering, Design and Selection》
- CFTR mass spectrometry palmitoylation post-translational modification protein purification;
68.A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

机译：通过添加二硫键提高稳定性的重组免疫毒素的免疫原性降低
- 作者：Wenhai Liu;Masanori Onda;Changhoon Kim;Laiman Xiang;John E. Weldon;Byungkook Lee;Ira Pastan
- 期刊名称：《Protein Engineering, Design and Selection》
- disulfide bond immunotoxin immunogenicity;
69.An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein DSC and NMR

机译：结合FKBP-mTOR融合蛋白DSC和NMR评估FKBP12依赖性和非依赖性mTOR抑制剂的评估工具
- 作者：Mitsuhiro Sekiguchi;Yoshihiro Kobashigawa;Masashi Kawasaki;Masashi Yokochi;Tetsuo Kiso;Ken-ichi Suzumura;Keitaro Mori;Toshio Teramura;Fuyuhiko Inagaki
- 期刊名称：《Protein Engineering, Design and Selection》
- DSC FRB domain NMR fusion protein;
70.The Class D β-lactamase family: residues governing the maintenance and diversity of function

机译：D类β-内酰胺酶家族：控制功能维持和功能多样性的残基
- 作者：Agnieszka Szarecka;Kimberly R. Lesnock;Carlos A. Ramirez-Mondragon;Hugh B. Nicholas Jr;Troy Wymore
- 期刊名称：《Protein Engineering, Design and Selection》
- Class D β-lactamase disulfide bond group entropy protein evolution structure–function relationship;
71.Systematic placement of structural water molecules for improved scoring of protein–ligand interactions

机译：系统地放置结构水分子以改善蛋白质-配体相互作用的评分
- 作者：David J. Huggins;Bruce Tidor
- 期刊名称：《Protein Engineering, Design and Selection》
- dead-end elimination inverse molecular design protein–ligand interaction scoring function structural water molecules;
72.Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences

机译：进化通往新蛋白质折叠的桥梁：C末端Cro蛋白质变色龙序列的设计
- 作者：William J. Anderson;Laura O. Van Dorn;Wendy M. Ingram;Matthew H. J. Cordes
- 期刊名称：《Protein Engineering, Design and Selection》
- chameleon sequence protein design NMR spectroscopy;
73.Conversion of scFv peptide-binding specificity for crystal chaperone development

机译：scFv肽结合特异性转化为晶体伴侣的发展。
- 作者：Jennifer C. Pai;Jeffrey A. Culver;Jason E. Drury;Rakesh S. Motani;Raquel L. Lieberman;Jennifer A. Maynard
- 期刊名称：《Protein Engineering, Design and Selection》
- antibody binding affinity co-crystallization protein complex protein engineering;
74.Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid β-lactamase display

机译：使用杂种β-内酰胺酶展示的抗CD22免疫毒素CAT-8015的抗原决定簇定位和关键氨基酸鉴定
- 作者：D. Bannister;B. Popovic;S. Sridharan;F. Giannotta;P. Filée;N. Yilmaz;R. Minter
- 期刊名称：《Protein Engineering, Design and Selection》
- beta-lactamase display CD22 epitope mapping immunotoxin;
75.Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin

机译：结合多种血清型肉毒杆菌神经毒素的中和人单克隆抗体
- 作者：C. Garcia-Rodriguez;I.N. Geren;J. Lou;F. Conrad;C. Forsyth;W. Wen;S. Chakraborti;H. Zao;G. Manzanarez;T.J. Smith;J. Brown;W.H. Tepp;N. Liu;S. Wijesuriya;M.T. Tomic;E.A. Johnson;L.A. Smith;J.D. Marks
- 期刊名称：《Protein Engineering, Design and Selection》
- botulism botulinum neurotoxin molecular evolution single-chain Fv yeast display;
76.Construction and maintenance of randomized retroviral expression libraries for transmembrane protein engineering

机译：跨膜蛋白工程随机逆转录病毒表达文库的构建和维护
- 作者：Sara A. Marlatt;Yong Kong;Tobin J. Cammett;Gregory Korbel;James P. Noonan;Daniel DiMaio
- 期刊名称：《Protein Engineering, Design and Selection》
- bovine papillomavirus E5 protein randomization sequencing traptamers;
77.Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes

机译：活性重组eIF5A的生产：通过与修饰酶共表达在大肠杆菌中重建eIF5A的真核生物酪氨酸修饰
- 作者：Jong Hwan Park;Camila A. O. Dias;Seung Bum Lee;Sandro R. Valentini;Masaaki Sokabe;Christopher S. Fraser;Myung Hee Park
- 期刊名称：《Protein Engineering, Design and Selection》
- eIF5A hypusine polyamine polycistronic vector post-translational modification;
78.A novel sequence-based antigenic distance measure for H1N1 with application to vaccine effectiveness and the selection of vaccine strains

机译：一种新型的基于序列的H1N1抗原距离测定方法用于疫苗有效性和疫苗株的选择
- 作者：Keyao Pan;Krystina C. Subieta;Michael W. Deem
- 期刊名称：《Protein Engineering, Design and Selection》
- antigenic distance antigenic drift influenza pepitope vaccine effectiveness;
79.The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays

机译：使用生物信息学过滤器和肽阵列鉴定新型环状依赖AMP的蛋白激酶锚定蛋白
- 作者：William A. McLaughlin;Tingjun Hou;Susan S. Taylor;Wei Wang
- 期刊名称：《Protein Engineering, Design and Selection》
- A-kinase anchoring proteins cAMP signaling computational prediction peptide array protein–protein interactions;
80.Computational design of the lasso peptide antibiotic microcin J25

机译：套索肽抗生素微素J25的计算设计
- 作者：Si Jia Pan;Wai Ling Cheung;Ho Ki Fung;Christodoulos A. Floudas;A. James Link
- 期刊名称：《Protein Engineering, Design and Selection》
- antimicrobial peptide cyclic peptide global optimization lasso peptide protein design;
81.Adnectins: engineered target-binding protein therapeutics

机译：Adnectins：工程化的靶标结合蛋白疗法
- 作者：D. Lipovšek
- 期刊名称：《Protein Engineering, Design and Selection》
- sup10/supFn3 Adnectin Engineered therapeutic proteins mRNA display PROfusion;
82.Biopharmaceuticals and monoclonal antibodies in oncology trials—a cross-sectional analysis

机译：肿瘤学试验中的生物药物和单克隆抗体—横断面分析
- 作者：T. Janowitz
- 期刊名称：《Protein Engineering, Design and Selection》
- biopharmaceuticals cancer clinical trials cross-sectional analysis monoclonal antibody;
83.Mutational analysis of kinetic partitioning in protein folding and protein–DNA binding

机译：蛋白质折叠和蛋白质-DNA结合中动力学分配的突变分析
- 作者：Ignacio E. Sánchez;Diego U. Ferreiro;Gonzalo de Prat Gay
- 期刊名称：《Protein Engineering, Design and Selection》
- kinetic partitioning point mutation protein design protein–DNA binding protein folding;
84.Expression of soluble active fragments of the morphogenetic protein SpoIIE from Bacillus subtilis using a library-based construct screen

机译：使用基于文库的构建体筛选表达枯草芽孢杆菌形态发生蛋白SpoIIE的可溶性活性片段
- 作者：Andrea E. Rawlings;Vladimir M. Levdikov;Elena Blagova;Vicki L. Colledge;Philippe J. Mas;James Tunaley;Ludmila Vavrova;Keith S. Wilson;Imrich Barak;Darren J. Hart;Anthony J. Wilkinson
- 期刊名称：《Protein Engineering, Design and Selection》
- SpoIIE sporulation ESPRIT phosphatase cell division;
85.Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins

机译：调节人血清白蛋白结构域III：双抗体融合蛋白的血清持久性
- 作者：Vania E. Kenanova;Tove Olafsen;Felix B. Salazar;Lawrence E. Williams;Scott Knowles;Anna M. Wu
- 期刊名称：《Protein Engineering, Design and Selection》
- blood clearance FcRn HSA DIII PET imaging protein scaffold;
86.Subunit and small-molecule interaction of ribonucleotide reductases via surface plasmon resonance biosensor analyses

机译：通过表面等离振子共振生物传感器分析核糖核苷酸还原酶的亚基和小分子相互作用
- 作者：Mikael Crona;Ernst Furrer;Eduard Torrents;David R. Edgell;Britt-Marie Sjöberg
- 期刊名称：《Protein Engineering, Design and Selection》
- Bacillus anthracis biotin-streptavidin immobilization inhibitors interaction constants nucleotides;
87.Sub-AQUA: real-value quality assessment of protein structure models

机译：Sub-AQUA：蛋白质结构模型的实值质量评估
- 作者：Yifeng David Yang;Preston Spratt;Hao Chen;Changsoon Park;Daisuke Kihara
- 期刊名称：《Protein Engineering, Design and Selection》
- error estimation homology modeling model quality assessment protein structure prediction regression analysis threading;
88.Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody

机译：通过定点掩蔽在细胞表面蛋白中进行抗原决定基定位：定义单克隆抗体对NTPDase3抑制的结构要素
- 作者：Vasily V. Ivanenkov;Patrick A. Crawford;Aimi Toyama;Jean Sévigny;Terence L. Kirley
- 期刊名称：《Protein Engineering, Design and Selection》
- alanine scanning mutagenesis ecto-nucleotidase epitope mapping NTPDase site-directed masking;
89.Structural analysis of thermostabilizing mutations of cocaine esterase

机译：可卡因酯酶热稳定突变的结构分析
- 作者：Diwahar Narasimhan;Mark R. Nance;Daquan Gao;Mei-Chuan Ko;Joanne Macdonald;Patricia Tamburi;Dan Yoon;Donald M. Landry;James H. Woods;Chang-Guo Zhan;John J.G. Tesmer;Roger K. Sunahara
- 期刊名称：《Protein Engineering, Design and Selection》
- cocaine esterase computational drug abuse thermostable;
90.A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

机译：人类溶菌酶（I59T）的非天然变体模仿了导致家族性淀粉样变性病形式的I56T变体的体外行为
- 作者：Christine L. Hagan;Russell J.K. Johnson;Anne Dhulesia;Mireille Dumoulin;Janice Dumont;Erwin De Genst;John Christodoulou;Carol V. Robinson;Christopher M. Dobson;Janet R. Kumita
- 期刊名称：《Protein Engineering, Design and Selection》
- fibril formation human lysozyme protein misfolding systemic amyloidosis;
91.Creating novel proteins by combining design and selection

机译：通过结合设计和选择来创建新颖的蛋白质
- 作者：Tijana Z. Grove;Michael Hands;Lynne Regan
- 期刊名称：《Protein Engineering, Design and Selection》
- peptide binding protein design Rosetta Design split-GFP assay tetratricopeptide repeat protein 1 (TPR1);
92.Cancer cell-specific internalizing ligands from phage displayed β-lactamase-peptide fusion libraries

机译：来自噬菌体的癌细胞特异性内在配体展示了β-内酰胺酶-肽融合文库
- 作者：Girja S. Shukla;David N. Krag
- 期刊名称：《Protein Engineering, Design and Selection》
- cancer cell-internalized ligands enzyme prodrug therapy phage display β-lactamase;
93.Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant

机译：源自stefin A的工程支架蛋白的结构功能研究。I：SQM变体的开发
- 作者：Toni Hoffmann;Lukas Kurt Josef Stadler;Michael Busby;Qifeng Song;Anthony T. Buxton;Simon D. Wagner;Jason J. Davis;Paul Ko Ferrigno
- 期刊名称：《Protein Engineering, Design and Selection》
- circular dichroism spectroscopy epitope recognition peptide aptamer scaffold protein;
94.Engineering a two-helix bundle protein for folding studies

机译：工程两螺旋束蛋白进行折叠研究
- 作者：Charlotte A. Dodson;Neil Ferguson;Trevor J. Rutherford;Christopher M. Johnson;Alan R. Fersht
- 期刊名称：《Protein Engineering, Design and Selection》
- α-helix model protein protein structure two-helix bundle two state folding mechanism;
95.Reengineering natural design by rational design and in vivo library selection: the HLH subdomain in bHLHZ proteins is a unique requirement for DNA-binding function

机译：通过合理的设计和体内文库选择来重新设计自然设计：bHLHZ蛋白中的HLH子域是DNA结合功能的独特要求
- 作者：Jing Xu;Antonia T. De Jong;Gang Chen;Hiu-Kwan Chow;Christopher O. Damaso;Adrian Schwartz Mittelman;Jumi A. Shin
- 期刊名称：《Protein Engineering, Design and Selection》
- Arnt C/EBP conformational adaptability fluorescence anisotropy Max;
96.Directed evolution of copper nitrite reductase to a chromogenic reductant

机译：将亚硝酸铜还原酶定向进化为发色还原剂
- 作者：Iain S. MacPherson;Federico I. Rosell;Melanie Scofield;A. Grant Mauk;Michael E.P. Murphy
- 期刊名称：《Protein Engineering, Design and Selection》
- colony screen crystallography directed evolution electrochemistry nitrite reductase;
97.The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold

机译：在从纤连蛋白支架中选择高亲和力免疫球蛋白G结合物时完整的氨基酸库优于丝氨酸/酪氨酸
- 作者：Benjamin J. Hackel;K. Dane Wittrup
- 期刊名称：《Protein Engineering, Design and Selection》
- fibronectin type III domain Fn3 immunoglobulin G protein engineering synthetic library;
98.Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2

机译：新型杂合酶的工程设计：具有三重催化活性的抗炎药物靶标将花生四烯酸直接转化为炎性前列腺素E2
- 作者：Ke-He Ruan;Vanessa Cervantes;Shui-Ping So
- 期刊名称：《Protein Engineering, Design and Selection》
- cyclooxygenase (COX) inflammation prostaglandin E2 (PGE2) prostaglandin E2 synthase (PGES) protein engineering;
99.Towards evolving a better repressor

机译：致力于发展更好的阻遏物
- 作者：Robert Daber;Mitchell Lewis
- 期刊名称：《Protein Engineering, Design and Selection》
- induction regulation repression transcription;
100.The consequences of pathogenic mutations to the human prion protein

机译：致病性突变对人类病毒蛋白的影响
- 作者：Marc W. van der Kamp;Valerie Daggett
- 期刊名称：《Protein Engineering, Design and Selection》
- aggregation genetics protein stability TSE;