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Molecular Pharmacology

【机译】：分子药理学

ISSN：-
出版周期：Monthly
语言：English

起始发布年份：1965
出版者：Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics
出版地：United States

NLM刊名缩写：Mol Pharmacol

数据库引入：PubMed: v1n1,Jul. 1965-

MeSH词表主题词：Pharmacology*

备注：Publication of the American Society for Pharmacology and Experimental展开▼

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1.POTENT INHIBITION OF HUMAN AP ENDONUCLEASE 1 BY ARYLSTIBONIC ACIDS

机译：杏基酸对人AP核酸酶1的潜在抑制作用
- 作者：Lauren A. Seiple;John H. Cardellina II;Rhone Akee;James T. Stivers
- 期刊名称：《Molecular Pharmacology》
2.Repression of Aryl Hydrocarbon Receptor (AHR) Signaling by AHR Repressor: Role of DNA Binding and Competition for AHR Nuclear Translocator

机译：AHR阻遏物抑制芳烃受体（AHR）信号：DNA结合和AHR核转运子竞争的作用
- 作者：Brad R. Evans;Sibel I. Karchner;Lenka L. Allan;Richard S. Pollenz;Robert L. Tanguay;Matthew J. Jenny;David H. Sherr;Mark E. Hahn
- 期刊名称：《Molecular Pharmacology》
3.Conformational Flexibility of Helix VI is Essential for Substrate Permeation of the Human Apical Sodium-dependent Bile Acid Transporter (ASBT)

机译：螺旋VI的构象灵活性对于人类根尖钠依赖性胆汁酸转运蛋白（ASBT）的底物渗透至关重要
- 作者：Naissan Hussainzada;Akash Khandewal;Peter W. Swaan
- 期刊名称：《Molecular Pharmacology》
4.Conformational Variations of Both Phosphodiesterase-5 and Inhibitors Provide the Structural Basis for the Physiological Effects of Vardenafil and Sildenafil

机译：磷酸二酯酶5和抑制剂的构象变化为伐地那非和西地那非的生理效应提供了结构基础
- 作者：Huanchen Wang;Mengchun Ye;Howard Robinson;Sharron H. Francis;Hengming Ke
- 期刊名称：《Molecular Pharmacology》
5.Electrophysiological Properties of Cardiomyocytes Isolated from CYP2J2 Transgenic Mice

机译：CYP2J2转基因小鼠心肌细胞的电生理特性
- 作者：Qingen Ke;Yong-Fu Xiao;J. Alyce Bradbury;Joan P. Graves;Laura M. DeGraff;John M. Seubert;Darryl C. Zeldin
- 期刊名称：《Molecular Pharmacology》
6.Structural Determinates for Apolipoprotein E-Derived Peptide Interaction with the α7 Nicotinic Acetylcholine Receptor

机译：载脂蛋白E衍生肽与α7烟碱乙酰胆碱受体相互作用的结构决定。
- 作者：Elaine A. Gay;Rachelle J. Bienstock;Patricia W. Lamb;Jerrel L. Yakel
- 期刊名称：《Molecular Pharmacology》
7.Extracellular Signal-Regulated Kinase Is an Endogenous Signal Retaining the Nuclear Constitutive Active/Androstane Receptor (CAR) in the Cytoplasm of Mouse Primary Hepatocytes

机译：细胞外信号调节激酶是一种内源性信号在小鼠原代肝细胞的细胞质中保留核组成性主动/雄激素受体（CAR）。
- 作者：Chika Koike;Rick Moore;Masahiko Negishi
- 期刊名称：《Molecular Pharmacology》
8.Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077)

机译：新型选择性慢后超极化通道阻断剂3-（三苯基甲基氨基甲基）吡啶（UCL2077）增强海马锥体细胞兴奋性。
- 作者：Mala M. Shah;Mazyar Javadzadeh-Tabatabaie;David C. H. Benton;C. Robin Ganellin;Dennis G. Haylett
- 期刊名称：《Molecular Pharmacology》
9.Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

机译：靶向效应记忆T细胞与Kv1.3通道的选择性肽抑制剂治疗自身免疫性疾病
- 作者：Christine Beeton;Michael W. Pennington;Heike Wulff;Satendra Singh;Daniel Nugent;George Crossley;Ilya Khaytin;Peter A. Calabresi;Chao-Yin Chen;George A. Gutman;K. George Chandy
- 期刊名称：《Molecular Pharmacology》
10.Alternative Promoters Determine Tissue-Specific Expression Profiles of the Human Microsomal Epoxide Hydrolase Gene (EPHX1)

机译：替代启动子确定人微粒体环氧水解酶基因（EPHX1）的组织特异性表达谱。
- 作者：Shun-Hsin Liang;Christopher Hassett;Curtis J. Omiecinski
- 期刊名称：《Molecular Pharmacology》
11.Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3 Adenosine Receptor

机译：鉴定涉及人A3腺苷受体的变构调节的基本残基
- 作者：ZHAN-GUO GAO;SOO-KYUNG KIM;ARIEL S. GROSS;AISHE CHEN;JOSHUA B. BLAUSTEIN;KENNETH A. JACOBSON
- 期刊名称：《Molecular Pharmacology》
12.A3 Adenosine Receptors in Human Astrocytoma Cells: Agonist-Mediated Desensitization Internalization and Down-Regulation

机译：人类星形细胞瘤细胞中的A3腺苷受体：激动剂介导的脱敏内在化和下调。
- 作者：M. L. TRINCAVELLI;D. TUSCANO;M. MARRONI;A. FALLENI;V. GREMIGNI;S. CERUTI;M. P. ABBRACCHIO;K. A. JACOBSON;F. CATTABENI;C. MARTINI
- 期刊名称：《Molecular Pharmacology》
13.Quantitation of the P2Y1 Receptor with a High Affinity Radiolabeled Antagonist

机译：高亲和力放射性标记的拮抗剂对P2Y1受体的定量
- 作者：Gary L. Waldo;James Corbitt;José L. Boyer;Gnana Ravi;Hak Sung Kim;Xiao-Duo Ji;James Lacy;Kenneth A. Jacobson;T. Kendall Harden
- 期刊名称：《Molecular Pharmacology》
14.Selective Allosteric Enhancement of Agonist Binding and Function at Human A3 Adenosine Receptors by a Series of Imidazoquinoline Derivatives

机译：一系列咪唑喹啉衍生物对人A3腺苷受体激动剂结合和功能的选择性变构增强。
- 作者：Zhan-Guo Gao;Seong Gon Kim;Kelly A. Soltysiak;Neli Melman;Adriaan P. Ijzerman;Kenneth A. Jacobson
- 期刊名称：《Molecular Pharmacology》
15.Allosteric Modulation of A3 Adenosine Receptors by a Series of 3-(2-Pyridinyl)isoquinoline Derivatives

机译：一系列3-（2-吡啶基）异喹啉衍生物对A3腺苷受体的变构调节。
- 作者：Zhan-Guo Gao;Jacqueline E. Van Muijlwijk-Koezen;Aishe Chen;Christa E. Müller;Adriaan P. Ijzerman;Kenneth A. Jacobson
- 期刊名称：《Molecular Pharmacology》
16.Selective Potentiation of Paclitaxel (Taxol)-Induced Cell Death by Mitogen-Activated Protein Kinase Kinase Inhibition in Human Cancer Cell Lines

机译：紫杉醇（紫杉醇）诱导的人类癌细胞系中的丝裂素活化的蛋白激酶激酶抑制细胞死亡的选择性增强。
- 作者：Hayley M. McDaid;Susan Band Horwitz
- 期刊名称：《Molecular Pharmacology》
17.Persistent Activation by and Receptor Reserve for an Irreversible A1-Adenosine Receptor Agonist in DDT1 MF-2 Cells and in Guinea Pig Heart

机译：不可逆的A1-腺苷受体激动剂在DDT1 MF-2细胞和豚鼠心脏中的持久活化和受体储备
- 作者：JIAHUI ZHANG;LUIZ BELARDINELLI;KENNETH A. JACOBSON;DEBORAH H. OTERO;STEPHEN P. BAKER
- 期刊名称：《Molecular Pharmacology》
18.A Mutational Analysis of Residues Essential for Ligand Recognition at the Human P2Y1 Receptor

机译：对人类P2Y1受体配体识别必不可少的残基进行突变分析。
- 作者：QIAOLING JIANG;DANPING GUO;BRIAN X. LEE;A. MICHIEL VAN RHEE;YONG-CHUL KIM;ROBERT A. NICHOLAS;JOEL B. SCHACHTER;T. KENDALL HARDEN;KENNETH A. JACOBSON
- 期刊名称：《Molecular Pharmacology》
19.Expression of Human NAD(P)H:Quinone Oxidoreductase (DT-Diaphorase) in Chinese Hamster Ovary Cells: Effect on the Toxicity of Antitumor Quinones

机译：人NAD（P）H：奎宁氧化还原酶（DT-Diaphorase）在中国仓鼠卵巢细胞中的表达：对抗肿瘤醌毒性的影响
- 作者：DANIEL L. GUSTAFSON;HOWARD D. BEALL;EMIKO M. BOLTON;DAVID ROSS;CHARLES A. WALDREN
- 期刊名称：《Molecular Pharmacology》
20.125I-4-(2-7-Amino-2-{2-furyl}{124}triazolo{23-a}{135}triazin-5-yl-aminoethyl)phenol a High Affinity Antagonist Radioligand Selective for the A2a Adenosine Receptor

机译：125I-4-（2- 2-氨基-2- {2-呋喃基} {124}三唑并{23-a} {135}三嗪-5-基-氨基乙基）苯酚对A2a腺苷受体具有选择性的高亲和力拮抗剂放射性配体
- 作者：TIMOTHY M. PALMER;SIMON M. POUCHER;KENNETH A. JACOBSON;GARY L STILES
- 期刊名称：《Molecular Pharmacology》
21.Differential Down- and Up-regulation of Rat Brain Opioid Receptor Types and Subtypes by Buprenorphine

机译：丁丙诺啡对大鼠脑阿片受体类型和亚型的差异下调和上调
- 作者：MARIANA M. BELCHEVA;JACOB BARG;ROBERT J. McHALE;SAMUEL DAWN;MATTHEW T. HO;ELENA IGNATOVA;CARMINE J. COSCIA
- 期刊名称：《Molecular Pharmacology》
22.The A2 Adenosine Receptor: Guanine Nucleotide Modulation of Agonist Binding Is Enhanced by Proteolysis

机译：A2腺苷受体：激动剂结合的鸟嘌呤核苷酸调节通过蛋白水解增强。
- 作者：CHRISTIAN NANOFF;KENNETH A. JACOBSON;GARY L. STILES
- 期刊名称：《Molecular Pharmacology》
23.Glycoprotein Nature of the A2-Adenosine Receptor Binding Subunit

机译：A2-腺苷受体结合亚基的糖蛋白性质
- 作者：William W. Barrington;Kenneth A. Jacobson;Gary L. Stiles
- 期刊名称：《Molecular Pharmacology》
24.Analysis of Agonist-Antagonist Interactions at A1 Adenosine Receptors

机译：A1腺苷受体激动剂-拮抗剂相互作用的分析
- 作者：EDWARD LEUNG;KENNETH A. JACOBSON;RICHARD D. GREEN
- 期刊名称：《Molecular Pharmacology》
25.High Affinity Acylating Antagonists for the A1 Adenosine Receptor: Identification of Binding Subunit

机译：A1腺苷受体的高亲和力酰化拮抗剂：结合亚基的鉴定。
- 作者：GARY L. STILES;KENNETH A. JACOBSON
- 期刊名称：《Molecular Pharmacology》
26.A New High Affinity Iodinated Adenosine Receptor Antagonist as a Radioligand/Photoaffinity Crosslinking Probe

机译：一种新型的高亲和力碘化腺苷受体拮抗剂作为放射性配体/光亲和力交联探针
- 作者：Gary L. Stiles;Kenneth A. Jacobson
- 期刊名称：《Molecular Pharmacology》
27.Correction to Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer

机译：对将ErbB / MAPK信号级联确定为犬膀胱癌的治疗靶标的更正
- 期刊名称：《Molecular Pharmacology》
28.Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

机译：秋水仙碱结合位点剂DJ95克服了耐药性并展现出抗肿瘤功效
- 作者：Kinsie E. Arnst;Yuxi Wang;Zi-Ning Lei;Dong-Jin Hwang;Gyanendra Kumar;Dejian Ma;Deanna N. Parke;Qiang Chen;Jinliang Yang;Stephen W. White;Tiffany N. Seagroves;Zhe-Sheng Chen;Duane D. Miller;Wei Li
- 期刊名称：《Molecular Pharmacology》
29.The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells

机译：角雌激素和雌激素受体α引发乳腺癌细胞中雌激素诱导的细胞凋亡的结构-功能关系。
- 作者：Philipp Y. Maximov;Balkees Abderrahman;Yousef M. Hawsawi;Yue Chen;Charles E. Foulds;Antrix Jain;Anna Malovannaya;Ping Fan;Ramona F. Curpan;Ross Han;Sean W. Fanning;Bradley M. Broom;Daniela M. Quintana Rincon;Jeffery A. Greenland;Geoffrey L. Greene;V. Craig Jordan
- 期刊名称：《Molecular Pharmacology》
30.Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics

机译：气态信号分子一氧化氮和硫化氢的最新进展：捕获其功能的人类疗法的策略。
- 作者：Nathan S. Bryan;David J. Lefer
- 期刊名称：《Molecular Pharmacology》
31.Active-Site Tryptophan the Target of Antineoplastic C-Terminal Binding Protein Inhibitors Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

机译：活性部位色氨酸抗肿瘤C末端结合蛋白抑制剂的目标介导CtBP寡聚化和转录调控活动的抑制剂破坏。
- 作者：M. Michael Dcona;Priyadarshan K. Damle;Francisco Zarate-Perez;Benjamin L. Morris;Zaid Nawaz;Michael J. Dennis;Xiaoyan Deng;Sudha Korwar;Sahib J. Singh;Keith C. Ellis;William E. Royer;Dipankar Bandyopadhyay;Carlos Escalante;Steven R. Grossman
- 期刊名称：《Molecular Pharmacology》
32.Correction to Long-Acting β2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)–Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR

机译：校正长效β2-肾上腺素受体激动剂增强糖皮质激素受体（GR）介导的转录通过基因特异性机制而不是通过GR的通用效应
- 期刊名称：《Molecular Pharmacology》
33.Correction to Pathogen-Associated Molecular Pattern-Induced TLR2 and TLR4 Activation Increases Keratinocyte Production of Inflammatory Mediators and Is Inhibited by Phosphatidylglycerol

机译：对病原体相关的分子模式诱导的TLR2和TLR4活化的校正增加了炎症介质的角质形成细胞产生并被磷脂酰甘油抑制
- 期刊名称：《Molecular Pharmacology》
34.Correction to Sodium Ion Binding Pocket Mutations and Adenosine A2A Receptor Function

机译：校正钠离子结合口袋突变和腺苷A2A受体功能
- 期刊名称：《Molecular Pharmacology》
35.Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

机译：苯巴比妥介导的人类的机械洞察但不是小鼠妊娠X受体
- 作者：Linhao Li;Matthew A. Welch;Zhihui Li;Bryan Mackowiak;Scott Heyward;Peter W. Swaan;Hongbing Wang
- 期刊名称：《Molecular Pharmacology》
36.Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism

机译：单羧酸盐转运蛋白的表征和蛋白质组学 - 转录组研究6敲除小鼠：葡萄糖和脂质代谢中潜在作用的证据
- 作者：Robert S. Jones;Chengjian Tu;Ming Zhang;Jun Qu;Marilyn E. Morris
- 期刊名称：《Molecular Pharmacology》
37.Steady-State Activation and Modulation of the Concatemeric α1β2γ2L GABAA Receptor

机译：稳态激活和调节串联α1β2γ2LgabaA受体
- 作者：Allison L. Germann;Spencer R. Pierce;Ariel B. Burbridge;Joe Henry Steinbach;Gustav Akk
- 期刊名称：《Molecular Pharmacology》
38.Pharmacological Mechanistic and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs

机译：新型褪黑激素 - 莫昔芬药物缀合物作为乳腺癌药物的药理学机械和药代动力学评估
- 作者：Mahmud Hasan;Mohamed Akmal Marzouk;Saugat Adhikari;Thomas D. Wright;Benton P. Miller;Margarite D. Matossian;Steven Elliott;Maryl Wright;Madlin Alzoubi;Bridgette M. Collins-Burow;Matthew E. Burow;Ulrike Holzgrabe;Darius P. Zlotos;Robert E. Stratford;Paula A. Witt-Enderby
- 期刊名称：《Molecular Pharmacology》
39.The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain

机译：孔隙脂质界面：Ivabradine对Herg1孔结构域的亲脂酸的氨基酸决定簇的作用
- 作者：Laura Perissinotti;Jiqing Guo;Meruyert Kudaibergenova;James Lees-Miller;Marina Ol’khovich;Angelica Sharapova;German L. Perlovich;Daniel A. Muruve;Brenda Gerull;Sergei Yu Noskov;Henry J. Duff
- 期刊名称：《Molecular Pharmacology》
40.Modulation of Burst Firing of Neurons in Nucleus Reticularis of the Thalamus by GluN2C-Containing NMDA Receptors

机译：含GLUN2C的NMDA受体丘脑核近似岩中神经元爆发的调节
- 作者：Jinxu Liu;Gajanan P. Shelkar;Fabao Zhao;Rasmus P. Clausen;Shashank M. Dravid
- 期刊名称：《Molecular Pharmacology》
41.The L46P Mutant Confers a Novel Allosteric Mechanism of Resistance Toward the Influenza A Virus M2 S31N Proton Channel Blockers

机译：L46P突变体赋予肺部血压抗性的新型变体机制病毒M2 S31N质子沟道阻挡机
- 作者：Rami Musharrafieh;Panagiotis I. Lagarias;Chunlong Ma;Gene S. Tan;Antonios Kolocouris;Jun Wang
- 期刊名称：《Molecular Pharmacology》
42.Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

机译：小分子抑制剂确认泛素依赖于TOP2-DNA共价复合物的去除
- 作者：Rebecca L. Swan;Luke L.K. Poh;Ian G. Cowell;Caroline A. Austin
- 期刊名称：《Molecular Pharmacology》
43.Correction to Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

机译：功能性RNAi屏幕定义了EGFR依赖的HNSCC细胞系中不同的蛋白激酶脆弱性的校正
- 期刊名称：《Molecular Pharmacology》
44.Correction to CXL146 a Novel 4H-Chromene Derivative Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells

机译：校正CXL146一种新型的4H-铬衍生物靶向GRP78以选择性地消除多药抗癌细胞
- 期刊名称：《Molecular Pharmacology》
45.M3 Muscarinic Acetylcholine Receptor-Mediated Signaling is Regulated by Distinct Mechanisms

机译：M3肌肉素乙酰胆碱受体介导的信号通过明显的机制调节
- 作者：Jiansong Luo;John M. Busillo;Jeffrey L. Benovic
- 期刊名称：《Molecular Pharmacology》
46.Long-Acting β2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)–Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR

机译：长效β2-肾上腺素受体激动剂通过基因特异性机制而不是通用效应来增强糖皮质激素受体（GR）介导的转录
- 作者：Christopher F. Rider;Mohammed O. Altonsy;Mahmoud M. Mostafa;Suharsh V. Shah;Sarah Sasse;Martijn L. Manson;Dong Yan;Carina Kärrman-Mårdh;Anna Miller-Larsson;Anthony N. Gerber;Mark A. Giembycz;Robert Newton
- 期刊名称：《Molecular Pharmacology》
47.A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors

机译：尼古丁吡咯烷环的甲基扫描揭示了与α7和α4β2烟碱乙酰胆碱受体相互作用的显着差异
- 作者：Hong Xing;Kristin W. Andrud;Ferenc Soti;Anne Rouchaud;Stephan C. Jahn;Ziang Lu;Yeh-Hyon Cho;Sophia Habibi;Patrick Corsino;Svetoslav Slavov;James R. Rocca;Jon M. Lindstrom;Ron J. Lukas;William R. Kem
- 期刊名称：《Molecular Pharmacology》
48.Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4

机译：人趋化因子受体CXCR4早期信号步骤的动力学分析
- 作者：Cristina Perpiñá-Viciano;Ali Işbilir;Aurélien Zarca;Birgit Caspar;Laura E. Kilpatrick;Stephen J. Hill;Martine J. Smit;Martin J. Lohse;Carsten Hoffmann
- 期刊名称：《Molecular Pharmacology》
49.Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine

机译：吗啡调节神经系统中丰富和进化保守的阿片受体圆形RNA的鉴定
- 作者：Takeshi Irie;Rebecca Shum;Ioanna Deni;Amanda Hunkele;Valerie Le Rouzic;Jin Xu;Roger Wilson;Gregory W. Fischer;Gavril W. Pasternak;Ying-Xian Pan
- 期刊名称：《Molecular Pharmacology》
50.Chemical Pharmacological and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor

机译：GABAA 受体的新型丙烯酰胺衍生调节剂的化学、药理学和结构表征
- 作者：Hugo R Arias;Itaru Hamachi;Sophia Q Xu;Seiji Sakamoto;Marcelo O Ortells;Spencer R Pierce;Dina Manetti;Maria Novella Romanelli;Allison L Germann;Gustav Akk
- 期刊名称：《Molecular Pharmacology》 | 2023年第3期
51.Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

机译：肌型肌酸激酶的天然突变在体外以底物依赖性方式影响其经典和药理活性
- 作者：Eric P Mosher;Namandjé N Bumpus;Colten D Eberhard
- 期刊名称：《Molecular Pharmacology》 | 2021年第6期
52.CCT and CCT-Like Modular Protein Interaction Domains in WNK Signaling

机译：WNK 信号转导中的 CCT 和 CCT 样模块化蛋白相互作用结构域
- 作者：Clinton A Taylor IV;Melanie H Cobb
- 期刊名称：《Molecular Pharmacology》 | 2022年第4期
53.BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex

机译：BAY58-2667 通过不同的机制激活不同的可溶性鸟苷酸环化酶种类表明其在细胞中的主要靶标是无血红素的可溶性鸟苷酸环化酶-热休克蛋白 90 复合物
- 作者：Yue Dai;Dennis J Stuehr
- 期刊名称：《Molecular Pharmacology》 | 2023年第5期
54.Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance

机译：TARP γ8 选择性负变构调节剂 JNJ-55511118 对 AMPA 受体门控和通道电导的影响
- 作者：Ian D Coombs;Mark Farrant;Craig A Sexton;Stuart G Cull-Candy
- 期刊名称：《Molecular Pharmacology》 | 2022年第5期
55.Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

机译：β-arrestin 偏倚的 β 受体阻滞剂卡维地洛和 β2-肾上腺素能受体的小分子阳性变构调节剂之间独特的正协同作用
- 作者：Dean P Staus;Paula K Rambarat;Alem W Kahsai;Shashank Vege;Robert J Lefkowitz;Bruno N Valan;Andrew Liu;Seungkirl Ahn;Biswaranjan Pani;Tommaso Costa
- 期刊名称：《Molecular Pharmacology》 | 2021年第5期
56.TP53 Null Mutations Identify Lung Cancer Cell Lines with Highest Sensitivity to the Nontaxane Microtubule Inhibitor Eribulin

机译：TP53 无效突变可识别对非紫杉烷微管抑制剂艾立布林最敏感的肺癌细胞系
- 作者：Roshni Kalkur;Lynn E Heasley;Trista K Hinz;Jonathan Rabinovitch;Wyatt Hinkle
- 期刊名称：《Molecular Pharmacology》 | 2021年第2期
57.Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

机译：促胰液素氨基末端构效关系和与促胰液素受体对接部位的互补诱变
- 作者：Laurence J Miller;Patrick M Sexton;Sarah J Piper;Sweta Raval;Denise Wootten;Kaleeckal G Harikumar;Juliana E Milburn;Arthur Christopoulos
- 期刊名称：《Molecular Pharmacology》 | 2022年第6期
58.Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake

机译：酪氨酸激酶抑制对有机阴离子转运多肽 1B3 介导的摄取的影响
- 作者：Alice A Gibson;Kyle Z Pasquariello;Yan Jin;Vusumuzi N Hove;Jun Qu;Jeffrey C Miecznikowski;Shuiying Hu;Jason A Sprowl;Elizabeth R Hayden;Shichen Shen;Kenneth Anderson
- 期刊名称：《Molecular Pharmacology》 | 2022年第6期
59.Atypical Chemokine Receptor 3 Senses CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

机译：非典型趋化因子受体 3 通过 GPCR 激酶磷酸化感知CXC 趋化因子受体 4 激活
- 作者：Qiuyan Chen;Tracy M Handel;Christopher T Schafer;John J G Tesmer
- 期刊名称：《Molecular Pharmacology》 | 2023年第4期
60.Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors

机译：深入了解通过突变受体的正变构调节获得的 α4β2 烟碱乙酰胆碱受体亚型的差异脱敏
- 作者：Roger L Papke;Clare Stokes
- 期刊名称：《Molecular Pharmacology》 | 2023年第2期
61.Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells

机译：白藜芦醇结合核受体 4A1 （NR4A1）并在肺癌细胞中充当 NR4A1 拮抗剂
- 作者：Lei Zhang;Wenshe Ray Liu;Greg Martin;Kumaravel Mohankumar;Stephen Safe;Joshua Trae Hampton
- 期刊名称：《Molecular Pharmacology》 | 2022年第2期
62.Notice of Retraction: Acharya P Engel JC Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2α (eIF2α)-kinase (PERK) and general control nonderepressible-2 eIF2α kinase (GCN2) and global translational shutoff. Mol Pharmacol 76(3):503–515; DOI: https://doi.org/10.1124/mol.109.056002

机译：撤回通知：Acharya P、Engel JC、Correia MA （2009）高浓度蛋白酶体抑制剂对肝脏 CYP3A 的抑制：内质网（ER）应激诱导、RNA 依赖性蛋白激酶样 ER 结合的真核起始因子 2α （eIF2α）-激酶（PERK）和一般对照非抑制性 2 eIF2α 激酶（GCN2）激活的结果以及整体翻译关闭。分子药理学76（3）：503–515;DOI： https://doi.org/10.1124/mol.109.056002
- 期刊名称：《Molecular Pharmacology》 | 2021年第2期
63.Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone

机译：亚基内和亚基间类固醇结合位点独立和叠加介导内源性神经类固醇 allopregnanolone 的 α1β2γ2L GABAA 受体增强
- 作者：Alex S Evers;Yusuke Sugasawa;Joe Henry Steinbach;David E Reichert;Spencer R Pierce;Hiroki Tateiwa;Allison L Germann;Gustav Akk
- 期刊名称：《Molecular Pharmacology》 | 2021年第1期
64.Lubiprostone is a Non-Selective Activator of cAMP-Gated Ion Channels and Chloride Channel Protein 2 (Clc-2) Has a Minor Role in its Prosecretory Effect in Intestinal Epithelial Cells

机译：鲁比前列酮是 cAMP 门控离子通道的非选择性激活剂氯离子通道蛋白 2 （clc-2）在其肠上皮细胞中的分泌作用中起次要作用
- 作者：Apurva A Oak;Pattareeya Yottasan;Tifany Chu;J Du Bois;Jie Zhu;Onur Cil;Parth D Chhetri
- 期刊名称：《Molecular Pharmacology》 | 2022年第2期
65.The Small Molecule Antagonist KCI807 Disrupts Association of the Amino-Terminal Domain of the Androgen Receptor with ELK1 by Modulating the Adjacent DNA Binding Domain

机译：小分子拮抗剂 KCI807 通过调节相邻的 DNA 结合域来破坏雄激素受体的氨基末端结构域与 ELK1 的结合
- 作者：Manohar Ratnam;Yanfang Huang;Claire Soave;Seongho Kim;Luke Pardy;Peter E Shaw;Sally Yurgelevic;Charles Ducker;Gregory Auner;Nathan I Nicely;Naeyma Islam;Alex Dickson
- 期刊名称：《Molecular Pharmacology》 | 2023年第4期
66.VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

机译：VU6036720：首个有效的选择性体外异聚 Kir4.1/5.1 内向整流钾通道抑制剂
- 作者：Craig W Lindsley;Samantha J McClenahan;Olivier Boutaud;Robert Gresham III;C David Weaver;Gary A Sulikowski;Sujay V Kharade;Raymond Harris;Caitlin N Kent;Emily L Days;Ian M Romaine;Jerod S Denton;Changho Han;Andrew Terker;Jade C Williams;Elena Isaeva;Roman M Lazarenko;Alexander Staruschenko;Joshua A Bauer
- 期刊名称：《Molecular Pharmacology》 | 2022年第5期
67.Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling

机译：新型人源 RET 融合 NSCLC 细胞系对 RET 抑制剂和下游信号传导的差异调节具有异质性反应
- 作者：Andrew Goodspeed;Adriana Estrada-Bernal;Fumi Kinose;Anh T Le;Andrea E Doak;Aik-Choon Tan;Minjae Yoo;Uwe Rix;Laura Schubert;Robert C Doebele;Sarah E Ferrara
- 期刊名称：《Molecular Pharmacology》 | 2021年第6期
68.Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle

机译：血清素介导的 1 型血清素受体激活相反地调节支配后肢肌肉的大鼠感觉神经元的电压门控钙通道电流
- 作者：Joyce S Kim;Shouhao Zhou;Victor Ruiz-Velasco;Laura Anselmi;Marc P Kaufman
- 期刊名称：《Molecular Pharmacology》 | 2022年第5期
69.Antidepressants Produce Persistent Gαs-Associated Signaling Changes in Lipid Rafts after Drug Withdrawal

机译：停药后抗抑郁药在脂筏中产生持续的 Gαs 相关信号变化
- 作者：Mark M Rasenick;Nicolas B Senese
- 期刊名称：《Molecular Pharmacology》 | 2021年第2期
70.Multiomics Analyses Identify Proline Endopeptidase–Like Protein As a Key Regulator of Protein Trafficking a Pathway Underlying Alzheimer’s Disease Pathogenesis

机译：多组学分析确定脯氨酸内肽酶样蛋白是蛋白质运输的关键调节因子这是阿尔茨海默病发病机制的途径
- 作者：Mariana Lemos Duarte;Ivone Gomes;Bin Zhang;Chenge Liu;Amanda K Fakira;Lakshmi A Devi;Achla Gupta;Seshat M Mack;Minghui Wang;Ali Sharma
- 期刊名称：《Molecular Pharmacology》 | 2023年第1期
71.Differential In Vitro Pharmacological Profiles of Structurally Diverse Nociceptin Receptor Agonists in Activating G Protein and Beta-Arrestin Signaling at the Human Nociceptin Opioid Receptor

机译：结构多样的伤害感受蛋白受体激动剂在激活人伤害感受蛋白阿片受体的 G 蛋白和 β-arrestin 信号传导中的差异体外药理学特征
- 作者：James J Lu;Anika Mann;Nurulain T Zaveri;Stefan Schulz;Willma E Polgar;Pooja Dasgupta
- 期刊名称：《Molecular Pharmacology》 | 2021年第1期
72.A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward

机译：RGSz1 在腹外侧导水管周围灰色中在吗啡奖励调节中的区域和投射特异性作用
- 作者：Andrew Nicolais;Ivone Gomes;Angélica Torres-Berrío;Daniel Wacker;Feodora Bertherat;Kerri D Pryce;Venetia Zachariou;Lakshmi A Devi;Anne Ruiz;Randal A Serafini;Omar B Sanchez-Reyes;Farhana Sakloth
- 期刊名称：《Molecular Pharmacology》 | 2023年第1期
73.Effects of Small Molecule Ligands on ACKR3 Receptors

机译：小分子配体对 ACKR3 受体的影响
- 作者：Richard J Miller;Neha Malik;Wei Lv;Kirill A Martemyanov;Ikuo Masuho;Dongjun Ren;Gary E Schiltz;Iredia D Iyamu;Brittany E Hopkins
- 期刊名称：《Molecular Pharmacology》 | 2022年第3期
74.Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline

机译：热蛋白质组分析显示谷胱甘肽过氧化物酶 4 是自噬诱导剂茶碱的靶标
- 作者：Junya Kakegawa;Takashi Hatanaka;Masahiro Yokoyama;Toru Hosoi;Satoshi Ohtsuka;Koichiro Ozawa
- 期刊名称：《Molecular Pharmacology》 | 2021年第3期
75.Physiologic Targets and Modes of Action for CBL0137 a Lead for Human African Trypanosomiasis Drug Development

机译：CBL0137 的生理靶点和作用方式非洲人类锥虫病药物开发的领导
- 作者：Kojo Mensa-Wilmot;Michael P Pollastri;Paul J Guyett;Benjamin Hoffman;Baljinder Singh;Andrei Purmal;Carlos E Sanz-Rodríguez
- 期刊名称：《Molecular Pharmacology》 | 2022年第1期
76.A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling Cytoprotection in Vitro and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)

机译：小鼠 Keap1 的 C151 点突变消除了甲基巴多索隆（CDDO-ME）的 NRF2 信号传导、体外细胞保护和体内保肝作用
- 作者：Nobunao Wakabayashi;Masayuki Yamamoto;Harini Srinivasan;Yoko Yagishita;Takafumi Suzuki;Tanvi Joshi;Tonibelle Gatbonton-Schwager;Thomas W Kensler
- 期刊名称：《Molecular Pharmacology》 | 2023年第2期
77.Commentary on Novel Interaction of the Dopamine D2 Receptor and the Ca2+ Binding Protein S100B: Role in D2 Receptor Function

机译：多巴胺 D2 受体和 Ca2+ 结合蛋白 S100B 的新型相互作用：在 D2 受体功能中的作用的评论
- 作者：Dayana Rodriguez-Contreras;Kim A Neve;Hun-Joo Lee
- 期刊名称：《Molecular Pharmacology》 | 2021年第2期
78.Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil

机译：抑制人尿嘧啶 DNA 糖基化酶使大部分结直肠癌细胞对 5-氟脱氧尿嘧啶和雷替曲塞敏感但对氟尿嘧啶不敏感
- 作者：Eric S Christenson;Anthony Gizzi;Matthew Egleston;Junru Cui;Michael DePasquale;Benjamin Orris;James T Stivers;Kyle J Seamon;Ben H Park
- 期刊名称：《Molecular Pharmacology》 | 2021年第6期
79.Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein–Coupled Receptors

机译：混合溶剂分子动力学模拟在 G 蛋白偶联受体变构位点预测中的应用
- 作者：John R Traynor;Heather A Carlson;Wallace KB Chan
- 期刊名称：《Molecular Pharmacology》 | 2023年第5期
80.Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

机译：纳米抗体介导的血管紧张素受体的双重空间结合拓宽了偏倚配体药理学
- 作者：Amanda R Keller;Laura M Wingler;Brandi M Small;Nayara Braga Emidio;Ross W Cheloha
- 期刊名称：《Molecular Pharmacology》 | 2024年第3期
81.Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1

机译：变构调节剂 KM822 通过与多巴胺转运蛋白 DAT-1 的相互作用减弱安非他明在秀丽隐杆线虫中的行为作用
- 作者：Osama Refai;Randy D Blakely;Joseph M Salvino;Ole V Mortensen;Zayna Gichi;Ivet Bahar;Shaili Aggarwal;Mary Hongying Cheng
- 期刊名称：《Molecular Pharmacology》 | 2022年第3期
82.Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

机译：咪咪啶酮抗癌药物 ONC201 的药理学特征揭示了 D2 多巴胺受体的负变构作用机制
- 作者：David R Sibley;Lei Shi;Varun V Prabhu;J Robert Lane;Marta Sanchez-Soto;Bing Xie;Caroline A Cuoco;Marilyn M Day;Joshua E Allen;Stéphane A Laporte;Yoon Namkung;R Benjamin Free;Blair KA Willette
- 期刊名称：《Molecular Pharmacology》 | 2021年第4期
83.The Synthetic Cannabinoid WIN55212-2 Can Disrupt the Golgi Apparatus Independent of Cannabinoid Receptor-1

机译：合成大麻素 WIN55212-2 可以独立于大麻素受体 1 破坏高尔基体
- 作者：Emily M Jutkiewicz;Joshua Lott;Manojkumar A Puthenveedu
- 期刊名称：《Molecular Pharmacology》 | 2022年第5期
84.Intracellular Allosteric Antagonist of the Olfactory Receptor OR51E2

机译：嗅觉受体 OR51E2 的细胞内变构拮抗剂
- 作者：Victor Kenyon;Maira Harume-Nagai;Tatjana Abaffy;Josh M Goldenberg;Terry Kenakin;Olivia Fu
- 期刊名称：《Molecular Pharmacology》 | 2024年第1期
85.β-Arrestin–Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection

机译：β-arrestin 偏倚的变构调节剂增强卡维地洛刺激的 β 肾上腺素能受体心脏保护
- 作者：Ilhan Gokhan;Alem W Kahsai;Jialu Wang;Howard A Rockman;Robert J Lefkowitz;Seungkirl Ahn;Biswaranjan Pani;Xinyu Xiong;Haoran Jiang
- 期刊名称：《Molecular Pharmacology》 | 2021年第6期
86.Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56

机译：六氢喹啉衍生物是粘附 G 蛋白偶联受体 ADGRG1/GPR56 的选择性激动剂
- 作者：Michael J Robertson;Gregory G Tall;Alexander L Vizurraga;Maiya Yu;Georgios Skiniotis
- 期刊名称：《Molecular Pharmacology》 | 2023年第1期
87.Mice Expressing Regulators of G protein Signaling–insensitive Gαo Define Roles of μ Opioid Receptor Gαo and Gαi Subunit Coupling in Inhibition of Presynaptic GABA Release

机译：表达 G 蛋白信号转导不敏感 Gαo 调节因子的小鼠定义了μ阿片受体 Gαo 和 Gαi 亚基偶联在抑制突触前 GABA 释放中的作用
- 作者：Susan L Ingram;Ming-hua Li;Courtney A Bouchet;Kylie B McPherson;John R Traynor
- 期刊名称：《Molecular Pharmacology》 | 2021年第3期
88.Decoding Cinnabarinic Acid–Specific Stanniocalcin 2 Induction by Aryl Hydrocarbon Receptor

机译：解码芳烃受体诱导的朱砂酸特异性 Stanniocalcin 2
- 作者：Aditya D Joshi;Hui Tang;Nikhil Y Patil;Iulia Rus;Kangling Zhang
- 期刊名称：《Molecular Pharmacology》 | 2022年第1期
89.The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families

机译：M3 毒蕈碱乙酰胆碱受体可以通过多个 G 蛋白家族发出信号
- 作者：Jeffrey S Smith;Andrew C Kruse;Meredith A Skiba;Ari S Hilibrand;Andrew N Dates;Victor G Calvillo-Miranda
- 期刊名称：《Molecular Pharmacology》 | 2024年第6期
90.A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants

机译：一种高通量筛选试验用于鉴定可以治疗由运输缺陷型 KV11.1 （hERG）变体引起的长 QT 综合征的药物
- 作者：Jeffrey Schmeckpeper;Christian L Egly;Björn C Knollmann;C David Weaver;Brian P Delisle;Daniel J Blackwell
- 期刊名称：《Molecular Pharmacology》 | 2022年第4期
91.Gα Protein Signaling Bias at Serotonin 1A Receptor

机译：5-羟色胺 1A 受体的 Gα 蛋白信号转导偏倚
- 作者：Rana Alabdali;Cesare Orlandi;Luca Franchini
- 期刊名称：《Molecular Pharmacology》 | 2023年第5期
92.Dynamic Expression of Transient Receptor Potential Vanilloid-3 and Integrated Signaling with Growth Factor Pathways during Lung Epithelial Wound Repair following Wood Smoke Particle and Other Forms of Lung Cell Injury

机译：木烟颗粒和其他形式的肺细胞损伤后肺上皮伤口修复过程中瞬时受体电位 Vanilloid-3 的动态表达和与生长因子通路的整合信号转导
- 作者：Tosifa A Memon;Nam D Nguyen;Christopher A Reilly;Samantha N Serna;John G Lamb;Emmanuel Rapp;Cassandra E Deering-Rice;Katherine L Burrell;Marysol Almestica-Roberts
- 期刊名称：《Molecular Pharmacology》 | 2021年第3期
93.Automated Intracellular Pharmacological Electrophysiology for Ligand-Gated Ionotropic Receptor and Pharmacology Screening

机译：用于配体门控离子型受体和药理学筛选的自动化细胞内药理学电生理学
- 作者：Mighten C Yip;Ona L McConnell;Andrew Jenkins;Eric T Wang;Riley E Perszyk;Craig R Forest;Stephen F Traynelis
- 期刊名称：《Molecular Pharmacology》 | 2021年第1期
94.Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

机译：内分泌成纤维细胞生长因子对全身能量代谢的昼夜节律调节
- 作者：Helmut Zarbl;Grace L Guo;Zhenning Yang
- 期刊名称：《Molecular Pharmacology》 | 2024年第3期
95.Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier

机译：实时组织成像揭示了血脑脊液屏障处有机阳离子和阴离子的不同跨细胞途径
- 作者：Austin Sun;Joanne Wang;Tao Hu;Weibin Zha
- 期刊名称：《Molecular Pharmacology》 | 2022年第5期
96.Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin

机译：顺铂诱导的头颈部肿瘤细胞的溶解消除
- 作者：Fereshteh Ahmadinejad;Erin Britt;Anthony C Faber;David A Gewirtz;Tasia Bos;Bin Hu;Joel D Leverson;Hisashi Harada;Andrew J Souers;Jennifer Koblinski
- 期刊名称：《Molecular Pharmacology》 | 2022年第3期
97.Decoding the Cardiac Actions of Protein Kinase D Isoforms

机译：解码蛋白激酶 D 亚型的心脏作用
- 作者：Susan F Steinberg
- 期刊名称：《Molecular Pharmacology》 | 2021年第6期
98.Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells

机译：依鲁替尼阻断黑色素瘤细胞中的 YAP1 活化并逆转 BRAF 抑制剂耐药性
- 作者：Sean A Misek;Andrea I Doseff;Bin Chen;Evgenii Chekalin;Richard R Neubig;Patrick A Newbury;Kathleen A Gallo;Shreya Paithankar
- 期刊名称：《Molecular Pharmacology》 | 2022年第1期
99.Use-Dependent Relief of Inhibition of Nav1.8 Channels by A-887826

机译：A-887826 对 Nav1.8 通道抑制的使用依赖性缓解
- 作者：Sooyeon Jo;Han-Xiong Bear Zhang;Bruce P Bean
- 期刊名称：《Molecular Pharmacology》 | 2023年第4期
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