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Molecular Neurodegeneration

Molecular Neurodegeneration

【机译】：分子神经退行性疾病

ISSN：-
出版周期：
语言：English

起始发布年份：2006
出版者：[London] : BioMed Central, 2006-
出版地：England

NLM刊名缩写：Mol Neurodegener

数据库引入：PubMed: v1, 2006-, PMC

MeSH词表主题词：Neurobiology; Neurodegenerative Diseases/genetics*Neurodegenerative Diseases/immunology*Neurodegenerative Diseases/therapy*

备注：Title from PDF caption (publisher's Web site, viewed July 19, 2006). Latest issue展开▼

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1.Retroviral vector-mediated hypoxia-regulated neurotrophin-3 gene transfer reduces apoptosis induced by hypoxia in PC12 cells

机译：逆转录病毒载体介导的缺氧调节的Neurotrophin-3基因转移减少缺氧诱导的PC12细胞凋亡
- 作者：Junfeng Zhang;Qindong Shi;Xinlin Chen;Pengbo Yang;Cunfang Qi;Jianshui Zhang;Haixia Lu;Lingyu Zhao;Bingqiao Zhao;Ping Zheng;Yong Liu
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
2.Glucocerebrosidase and its relevance to Parkinson disease

机译：葡萄糖脑苷脂酶及其与帕金森病的关系
- 作者：Jenny Do;Cindy McKinney;Pankaj Sharma;Ellen Sidransky
- 期刊名称：《Molecular Neurodegeneration》 | 2019年第-1期
- Gaucher disease GBA1 Parkinson disease Glucocerebrosidase α-Synuclein Lysosome;
3.Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

机译：抵消MHCI和CD8 + T细胞在ALS SOD1G93A小鼠的外周和中枢神经系统中的作用
- 作者：Giovanni Nardo;Maria Chiara Trolese;Mattia Verderio;Alessandro Mariani;Massimiliano de Paola;Nilo Riva;Giorgia Dina;Nicolò Panini;Eugenio Erba;Angelo Quattrini;Caterina Bendotti
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Amyotrophic lateral sclerosis SOD1G93A mice Neuroinflammation MHCI CD8+ T cells Motor neuron Peripheral nervous system;
4.Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death

机译：Caspase-7：视神经损伤引起的视网膜神经节细胞死亡的关键介质
- 作者：Shreyasi Choudhury;Yang Liu;Abbot F. Clark;Iok-Hou Pang
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Caspase-7 Optic nerve injury Retinal ganglion cell Neuroprotection;
5.Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

机译：小胶质细胞源性IL-1β促进局灶性视网膜变性中Müller细胞和RPE趋化因子的表达
- 作者：Riccardo Natoli;Nilisha Fernando;Michele Madigan;Joshua A. Chu-Tan;Krisztina Valter;Jan Provis;Matt Rutar
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Retinal degeneration Microglia Interleukin-1β IL-1β Chemokines RPE Müller cells Macrophages Age-related macular degeneration AMD;
6.Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism

机译：实验性帕金森病上调灵长类尾状核中组织蛋白酶D的表达
- 作者：Sowmya V Yelamanchili;Amrita Datta Chaudhuri;Claudia T Flynn;Howard S Fox
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Parkinsons MPTP striatum caudate neurodegeneration cathepsin apoptosis nonhuman primate;
7.Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel surgery-free model of traumatic brain injury

机译：使用CHIMERA（工程旋转加速度的闭合头冲击模型）将病理学与生物力学相结合：创伤性脑损伤的新型免手术模型
- 作者：Dhananjay R Namjoshi;Wai Hang Cheng;Kurt A McInnes;Kris M Martens;Michael Carr;Anna Wilkinson;Jianjia Fan;Jerome Robert;Arooj Hayat;Peter A Cripton;Cheryl L Wellington
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Traumatic brain injury Animal model of traumatic brain injury Animal model of closed head injury Diffuse axonal injury Microglia activation Neuroinflammation Tau hyperphosphorylation Head kinematics Head injury biomechanics Impact-acceleration traumatic brain injury model Surgery-free animal model of traumatic brain injury Traumatic brain injury biomechanics;
8.Serum from Parkinson’s disease patients presents excess of protein halogenation and nitrosylation with anomalous nitrosylation of serum α-synuclein as potentially etiological factor

机译：帕金森氏病患者的血清中存在过多的蛋白质卤化和亚硝化作用而血清α-突触核蛋白的亚硝化异常是潜在的病因
- 作者：Emilio Fernandez;Jose-Manuel Garcia-Moreno;Angel Martin de Pablos;Jose Chacon
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
9.Pioglitazone ameliorates the phenotype of a novel Parkinson’s disease mouse model by reducing neuroinflammation

机译：吡格列酮通过减少神经炎症改善了新型帕金森氏病小鼠模型的表型
- 作者：Milena Pinto;Nadee Nissanka;Susana Peralta;Roberta Brambilla;Francisca Diaz;Carlos T. Moraes
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- Mitochondria Pioglitazone Neuroinflammation;
10.Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

机译：校正至：将α-突触核蛋白预先形成的原纤维接种到小鼠胃肠道中通过迷走神经在脑干中诱导路易体样聚集体
- 作者：Norihito Uemura;Hisashi Yagi;Maiko T. Uemura;Yusuke Hatanaka;Hodaka Yamakado;Ryosuke Takahashi
- 期刊名称：《Molecular Neurodegeneration》 | 2019年第-1期
11.Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

机译：巨自噬缺陷通过磷酸-tau途径介导年龄依赖性神经变性。
- 作者：Keiichi Inoue;Joanne Rispoli;Hanoch Kaphzan;Eric Klann;Emily I Chen;Jongpil Kim;Masaaki Komatsu;Asa Abeliovich
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
12.mGluR5 regulated proliferation of neural stem cells after hypoxia with activation of MAPK signaling pathway

机译：缺氧后mGluR5通过激活MAPK信号通路调节神经干细胞的增殖
- 作者：Lingyu Zhao;Qian Jiao;Xinlin Chen;Pengbo Yang;Bingqiao Zhao;Ping Zheng;Yong Liu
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
13.Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

机译：靶向Toll样受体2的免疫疗法通过调节α-突触核蛋白的传递和神经炎症来减轻突触核病模型中的神经变性
- 作者：Changyoun Kim;Brian Spencer;Edward Rockenstein;Hodaka Yamakado;Michael Mante;Anthony Adame;Jerel Adam Fields;Deborah Masliah;Michiyo Iba;He-Jin Lee;Robert A. Rissman;Seung-Jae Lee;Eliezer Masliah
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Immunotherapy α-synuclein Toll-like receptor 2 Transmission Neuroinflammation Neurodegeneration Synucleinopathy Parkinson’s disease;
14.Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation

机译：与SNCA复制和H50Q突变相比G51D SNCA突变病例有明显的临床和神经病理学特征
- 作者：Aoife P. Kiely;Helen Ling;Yasmine T. Asi;Eleanna Kara;Christos Proukakis;Anthony H. Schapira;Huw R. Morris;Helen C. Roberts;Steven Lubbe;Patricia Limousin;Patrick A. Lewis;Andrew J. Lees;Niall Quinn;John Hardy;Seth Love;Tamas Revesz;Henry Houlden;Janice L. Holton
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Parkinson’s disease Multiple system atrophy α-synuclein Clinical features Phosphorylation Mutation SNCA;
15.The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

机译：PINK1 p.I368N突变影响蛋白质稳定性和泛素激酶活性
- 作者：Maya Ando;Fabienne C. Fiesel;Roman Hudec;Thomas R. Caulfield;Kotaro Ogaki;Paulina Górka-Skoczylas;Dariusz Koziorowski;Andrzej Friedman;Li Chen;Valina L. Dawson;Ted M. Dawson;Guojun Bu;Owen A. Ross;Zbigniew K. Wszolek;Wolfdieter Springer
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Parkinson’s disease PINK1 PARKIN Ubiquitin Mitophagy Autophagy PARK2 Mitochondria Phospho-ubiquitin E3 ubiquitin ligase;
16.Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53

机译：白细胞介素1β通过激活凋亡蛋白p53引起兴奋性神经变性和多发性硬化症疾病进展
- 作者：Silvia Rossi;Caterina Motta;Valeria Studer;Giulia Macchiarulo;Elisabetta Volpe;Francesca Barbieri;Gabriella Ruocco;Fabio Buttari;Annamaria Finardi;Raffaele Mancino;Sagit Weiss;Luca Battistini;Gianvito Martino;Roberto Furlan;Jelena Drulovic;Diego Centonze
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Apoptosis Glutamate Inflammation MS Synaptic transmission Tumor necrosis factor-α;
17.The role of SorLA in neurotrophic activity and complex behavior

机译：SorLA在神经营养活动和复杂行为中的作用
- 作者：Simon Glerup;Mart Saarma;Anders Nykjaer
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
18.High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

机译：需要线粒体复合物III和IV的高水平抑制以增加从神经末梢释放的谷氨酸盐
- 作者：Seán M Kilbride;Sonia A Gluchowska;Jayne E Telford;Catherine OSullivan;Gavin P Davey
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
19.Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

机译：抑制补体级联的经典途径可预防青光眼的早期树突和突触变性
- 作者：Pete A. Williams;James R. Tribble;Keating W. Pepper;Stephen D. Cross;B Paul Morgan;James E. Morgan;Simon W. M. John;Gareth R. Howell
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- Glaucoma Dendrite Synapse Complement C1 C1qa Retinal ganglion cell;
20.Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

机译：结合使用Maneb和百草枯可改变帕金森氏病小鼠模型中神经发生相关基因的转录调控
- 作者：Paula Desplats;Pruthul Patel;Kori Kosberg;Michael Mante;Christina Patrick;Edward Rockenstein;Masayo Fujita;Makoto Hashimoto;Eliezer Masliah
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Adult neurogenesis Parkinson’s disease Maneb Paraquat Pesticides Environmental exposure Gene expression Gene x environment interactions;
21.Self-renewal potential of NPCs decreased in vitro during human embryonic brain development with reduced activation of mitogen-activated protein kinases signaling

机译：在人胚胎脑发育过程中NPC的自我更新潜力在体外降低而丝裂原激活的蛋白激酶信号转导降低
- 作者：Lingyu Zhao;Qian Jiao;Xinlin Chen;Pengbo Yang;Bingqiao Zhao;Ping Zheng;Yong Liu
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
22.PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

机译：PU.1调节人类小胶质细胞中与阿尔茨海默氏病相关的基因
- 作者：Justin Rustenhoven;Amy M. Smith;Leon C. Smyth;Deidre Jansson;Emma L. Scotter;Molly E. V. Swanson;Miranda Aalderink;Natacha Coppieters;Pritika Narayan;Renee Handley;Chris Overall;Thomas I. H. Park;Patrick Schweder;Peter Heppner;Maurice A. Curtis;Richard L. M. Faull;Mike Dragunow
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Alzheimer’s disease Vorinostat Phagocytosis Antigen presentation Drug screening Neuroinflammation;
23.Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

机译：病理Tau N端特异的人源化单克隆抗体armanezumab：表征和治疗潜能
- 作者：Michael G. Agadjanyan;Karen Zagorski;Irina Petrushina;Hayk Davtyan;Konstantin Kazarian;Maxim Antonenko;Joy Davis;Charles Bon;Mathew Blurton-Jones;David H. Cribbs;Anahit Ghochikyan
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Alzheimer’s disease Tauopathy Phosphatase activation domain Immunotherapy Monoclonal antibody Humanization Therapeutic efficacy;
24.Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

机译：TDP-43转基因猪脑中RNA剪接因子的胞质错定位和异常神经元基因剪接
- 作者：Guohao Wang;Huaqiang Yang;Sen Yan;Chuan-En Wang;Xudong Liu;Bentian Zhao;Zhen Ouyang;Peng Yin;Zhaoming Liu;Yu Zhao;Tao Liu;Nana Fan;Lin Guo;Shihua Li;Xiao-Jiang Li;Liangxue Lai
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- TDP-43 PSF NeuN NMHC II-B ALS transgenic Pig;
25.Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1

机译：ubiquilin-1对阿尔茨海默氏病分子发病机理中关键蛋白的调控
- 作者：Mari Takalo;Jayashree Viswanathan;Teemu Natunen;Kaisa MA Kurkinen;Heikki Tanila;Hilkka Soininen;Rudolph E Tanzi;Mikko Hiltunen;Annakaisa Haapasalo
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
26.Replication of EPHA1 and CD33 associations with late-onset Alzheimers disease: a multi-centre case-control study

机译：EPHA1和CD33与迟发性阿尔茨海默氏病的复制：一项多中心病例对照研究
- 作者：Minerva M Carrasquillo;Olivia Belbin;Talisha A Hunter;Li Ma;Gina D Bisceglio;Fanggeng Zou;Julia E Crook;V Shane Pankratz;Sigrid B Sando;Jan O Aasly;Maria Barcikowska;Zbigniew K Wszolek;Dennis W Dickson;Neill R Graff-Radford;Ronald C Petersen;Peter Passmore;Kevin Morgan;Steven G Younkin
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
27.The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity adult neurogenesis and neuroinflammation

机译：新生儿辐照小鼠的认知缺陷伴有突触可塑性变化成年神经发生和神经炎症
- 作者：Stefan J Kempf;Arianna Casciati;Sonja Buratovic;Dirk Janik;Christine von Toerne;Marius Ueffing;Frauke Neff;Simone Moertl;Bo Stenerlöw;Anna Saran;Michael J Atkinson;Per Eriksson;Simonetta Pazzaglia;Soile Tapio
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Dendritic spines Hippocampus Cortex CREB miR-132 Ionising radiation Proteomics Rac1 Cofilin Alzheimer;
28.Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

机译：人类诱导的多能干细胞衍生神经元的亨廷顿舞蹈病病理表现
- 作者：Evgeny D. Nekrasov;Vladimir A. Vigont;Sergey A. Klyushnikov;Olga S. Lebedeva;Ekaterina M. Vassina;Alexandra N. Bogomazova;Ilya V. Chestkov;Tatiana A. Semashko;Elena Kiseleva;Lyubov A. Suldina;Pavel A. Bobrovsky;Olga A. Zimina;Maria A. Ryazantseva;Anton Yu. Skopin;Sergey N. Illarioshkin;Elena V. Kaznacheyeva;Maria A. Lagarkova;Sergey L. Kiselev
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- Huntington’s disease Human induced pluripotent stem cells Differentiation GABAergic medium spiny neurons Nuclear indentations Store-operated calcium entry Neurodegeneration Aging Neuroprotection;
29.Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

机译：超极化激活的环状核苷酸门控通道：在阿尔茨海默氏病中癫痫发作和Aβ生成之间的潜在分子联系
- 作者：Yuhki Saito;Tsuyoshi Inoue;Gang Zhu;Naoki Kimura;Motohiro Okada;Masaki Nishimura;Nobuyuki Kimura;Shigeo Murayama;Sunao Kaneko;Ryuichi Shigemoto;Keiji Imoto;Toshiharu Suzuki
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
30.Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats

机译：氧化性DNA损伤触发了6-OHDA处理的大鼠纹状体中ProNGF介导的细胞凋亡
- 作者：Tao Wang;Pingping Zuo;Piu Chan
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
31.Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

机译：视网膜下巨噬细胞产生经典补体激活剂C1q导致局灶性视网膜变性的发展
- 作者：Haihan Jiao;Matt Rutar;Nilisha Fernando;Ted Yednock;Sethu Sankaranarayanan;Riemke Aggio-Bruce;Jan Provis;Riccardo Natoli
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Macrophages Microglia Complement system Classical pathway C1q Inflammasome Retinal degeneration Photo-oxidative damage Inflammation Age-related macular degeneration;
32.A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

机译：新型BACE抑制剂NB-360在APP转基因小鼠中显示出优异的药理作用以及淀粉样β和神经炎症的强烈减少
- 作者：Ulf Neumann;Heinrich Rueeger;Rainer Machauer;Siem Jacob Veenstra;Rainer M. Lueoend;Marina Tintelnot-Blomley;Grit Laue;Karen Beltz;Barbara Vogg;Peter Schmid;Wilfried Frieauff;Derya R. Shimshek;Matthias Staufenbiel;Laura H. Jacobson
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Alzheimer’s disease BACE-1 Inhibitor Amyloid-β Neuroinflammation;
33.Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

机译：下调ANP32A通过阿尔茨海默病模型中的染色质重塑来挽救突触和记忆丧失
- 作者：Gao-Shang Chai;Qiong Feng;Zhi-Hao Wang;Yu Hu;Dong-Sheng Sun;Xiao-Guang Li;Dan Ke;Hong-Lian Li;Gong-Ping Liu;Jian-Zhi Wang
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Alzheimer’s disease ANP32A Histone acetylation Synapse Memory;
34.Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimers disease mouse model: mechanism for deficient glutamatergic transmission?

机译：年龄依赖性的三重转基因阿尔茨海默氏病小鼠模型海马星形胶质细胞中谷氨酰胺合成酶表达的下降：谷氨酸能缺乏传递的机制？
- 作者：Markel Olabarria;Harun N Noristani;Alexei Verkhratsky;José J Rodríguez
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Astroglia Alzheimers disease glutamine synthetase GFAP amyloid beta excitotoxicity hippocampus plasticity;
35.Associations between brain microstructures metabolites and cognitive deficits during chronic HIV-1 infection of humanized mice

机译：人源化小鼠的慢性HIV-1感染过程中脑微结构代谢产物和认知缺陷之间的关联
- 作者：Michael D Boska;Prasanta K Dash;Jaclyn Knibbe;Adrian A Epstein;Sidra P Akhter;Natasha Fields;Robin High;Edward Makarov;Stephen Bonasera;Harris A Gelbard;Larisa Y Poluektova;Howard E Gendelman;Santhi Gorantla
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- sup1/supH magnetic resonance spectroscopy Behavioral and cognitive deficits Diffusion tensor imaging HIV-1 Humanized mice;
36.O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

机译：O-GlcNAcylation增强了淀粉样β前体蛋白（APP）的非淀粉样生成过程
- 作者：Kristin Jacobsen;Kerstin Iverfeldt
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
37.Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons

机译：Frataxin缺乏症揭示胰岛素样生长因子I对神经元的细胞背景依赖性作用
- 作者：Carolina Franco;Silvia Fernández;Ignacio Torres-Alemán
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Friedreich’s ataxia Frataxin Insulin-like growth factor 1 Neuroprotection;
38.MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

机译：MicroRNA-7靶向Nod样受体蛋白3炎性体以调节帕金森氏病发病机理中的神经炎症
- 作者：Yan Zhou;Ming Lu;Ren-Hong Du;Chen Qiao;Chun-Yi Jiang;Ke-Zhong Zhang;Jian-Hua Ding;Gang Hu
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- microRNA-7 NLRP3 inflammasome α-Synuclein Neuroinflammation Parkinson’s disease;
39.C-terminal part of alpha-synuclein mediates its activity in promoting proliferation of dopaminergic cells

机译：α-突触核蛋白的C端部分介导其促进多巴胺能细胞增殖的活性
- 作者：Juanjuan Yin;Tao Wang;Junyan Han;Chen Zhang;Qiulan Ma;Xin Li;Furong Cheng;Guangwei Liu;Yaohua Li;Kenji Uéda;Piu Chan;Shun Yu
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
40.Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

机译：Calpain-1和脯氨酰内肽酶可产生阿尔茨海默氏症相关的神经颗粒性脑脊髓液碎片
- 作者：Bruno Becker;Faisal Hayat Nazir;Gunnar Brinkmalm;Elena Camporesi;Hlin Kvartsberg;Erik Portelius;Martina Boström;Marie Kalm;Kina Höglund;Maria Olsson;Henrik Zetterberg;Kaj Blennow
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Neurogranin Calpain Prolyl endopeptidase Postsynaptic protein IQ domain Biomarker Alzheimer’s disease;
41.Dioxins and related environmental contaminants increase TDP-43 levels

机译：二恶英和相关环境污染物会增加TDP-43的水平
- 作者：Peter E. A. Ash;Elizabeth A. Stanford;Ali Al Abdulatif;Alejandra Ramirez-Cardenas;Heather I. Ballance;Samantha Boudeau;Amanda Jeh;James M. Murithi;Yorghos Tripodis;George J. Murphy;David H. Sherr;Benjamin Wolozin
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Neurodegeneration ALS Protein aggregation Promoter Transcription Gene regulation Toxicants Alpha-synuclein Ataxin-2 Fus;
42.Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

机译：额颞痴呆相关的N279K tau突变体破坏了亚细胞囊泡运输并诱导了iPSC衍生的神经干细胞的细胞应激
- 作者：Melissa C. Wren;Jing Zhao;Chia-Chen Liu;Melissa E. Murray;Yuka Atagi;Mary D. Davis;Yuan Fu;Hirotaka J. Okano;Kotaro Ogaki;Audrey J. Strongosky;Pawel Tacik;Rosa Rademakers;Owen A. Ross;Dennis W. Dickson;Zbigniew K. Wszolek;Takahisa Kanekiyo;Guojun Bu
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- FTDP-17 iPSCs N279K Neural stem cells PPND Tau;
43.Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa

机译：Prpf31突变导致斑马鱼视网膜色素变性模型中的前mRNA剪接缺陷和杆感光细胞变性
- 作者：Jun Yin;Jan Brocher;Utz Fischer;Christoph Winkler
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Retinitis pigmentosa (RP) PRPF31 AD5 mutation SP117 mutation haploinsufficiency dominant-negative rod degeneration apoptosis splicing defect;
44.Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

机译：培养物中神经元膜胆固醇的增加概括了阿尔茨海默氏病的早期表型
- 作者：Catherine Marquer;Jeanne Laine;Luce Dauphinot;Linda Hanbouch;Camille Lemercier-Neuillet;Nathalie Pierrot;Koen Bossers;Mickael Le;Fabian Corlier;Caroline Benstaali;Frédéric Saudou;Gopal Thinakaran;Nathalie Cartier;Jean-Noël Octave;Charles Duyckaerts;Marie-Claude Potier
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Alzheimer’s disease Amyloid precursor protein Cholesterol Endosomes Neurons Axonal transport;
45.FcgRIIb mediates amyloid-β neurotoxicity and memory impairment in a model of Alzheimer’s disease

机译：FcgRIIb在阿尔茨海默氏病模型中介导淀粉样β神经毒性和记忆障碍
- 作者：Yong-Keun Jung
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
46.Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

机译：小鼠肉瘤突变中融合基因的表达概括了FUS蛋白病变的神经病理学并提供了疾病发病机理的见解
- 作者：Christophe Verbeeck;Qiudong Deng;Mariely DeJesus-Hernandez;Georgia Taylor;Carolina Ceballos-Diaz;Jannet Kocerha;Todd Golde;Pritam Das;Rosa Rademakers;Dennis W Dickson;Thomas Kukar
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Fused in sarcoma proteinopathies Transgenic mouse models Adeno-associated virus Neuronal cytoplasmic inclusions Ubiquitin p62/SQSTM1 α-internexin PABP-1 Stress granules RNA dysfunction;
47.Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson’s Disease

机译：对五个孟德尔基因和帕金森氏病全基因组关联研究中的顶级基因进行重新测序分析
- 作者：Bruno A. Benitez;Albert A. Davis;Sheng Chih Jin;Laura Ibanez;Sara Ortega-Cubero;Pau Pastor;Jiyoon Choi;Breanna Cooper;Joel S. Perlmutter;Carlos Cruchaga
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- Parkinson’s Association study SNCA LRRK2 PARKIN PINK1 DJ-1 MAPT GBA rare variants gene-based analysis;
48.Exploring the role of common regulatory variants in the etiology of late-onset Alzheimer’s disease

机译：探索常见调节变异体在晚期阿尔茨海默氏病病因中的作用
- 作者：Hao Wang;Min Zhu;Jian Wang;Yue Sun;Yu Tao;Qin He;Xiang Xu;Li Chen;David Saffen
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
49.Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

机译：小胶质细胞的早期溶酶体成熟缺陷触发了原粒蛋白敲除小鼠其他脑细胞的溶酶体活性增强
- 作者：Julia K. Götzl;Alessio-Vittorio Colombo;Katrin Fellerer;Anika Reifschneider;Georg Werner;Sabina Tahirovic;Christian Haass;Anja Capell
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Frontotemporal lobar degeneration Microglia Neurodegeneration Progranulin Lysosome Cathepsin;
50.Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease

机译：在帕金森氏病大鼠模型中胆碱能足小神经元神经元的药物遗传学刺激可逆转运动功能障碍
- 作者：Ilse S. Pienaar;Sarah E. Gartside;Puneet Sharma;Vincenzo De Paola;Sabine Gretenkord;Dominic Withers;Joanna L. Elson;David T. Dexter
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Cholinergic Deep brain stimulation DREADD Parkinson’s disease Pedunculopontine nucleus;
51.C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

机译：C-Jun N末端激酶控制TDP-43在氧化应激诱导的应激颗粒中的积累
- 作者：Jodi Meyerowitz;Sarah J Parker;Laura J Vella;Dominic CH Ng;Katherine A Price;Jeffrey R Liddell;Aphrodite Caragounis;Qiao-Xin Li;Colin L Masters;Takashi Nonaka;Masato Hasegawa;Marie A Bogoyevitch;Katja M Kanninen;Peter J Crouch;Anthony R White
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- TDP-43 stress granules JNK kinases oxidative stress paraquat hnRNP;
52.Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

机译：TDP-43突变体不会在体内和体外损害线粒体的生物能。
- 作者：Hibiki Kawamata;Pablo Peixoto;Csaba Konrad;Gloria Palomo;Kirsten Bredvik;Meri Gerges;Federica Valsecchi;Leonard Petrucelli;John M. Ravits;Anatoly Starkov;Giovanni Manfredi
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- TDP-43 TAR DNA-binding protein 43 Mitochondria Bioenergetics Calcium ALS;
53.Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice

机译：穿心莲内酯可减轻AβPPswe/ PS-1小鼠的认知障碍
- 作者：Felipe G Serrano;Cheril Tapia-Rojas;Francisco J Carvajal;Juan Hancke;Waldo Cerpa;Nibaldo C Inestrosa
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Alzheimer’s disease AβPP/PS-1 mice Water maze LTD GSK-3β;
54.Analysis of TDP-43 and its binding partners in neurodegenerative diseases

机译：TDP-43及其结合伴侣在神经退行性疾病中的分析
- 作者：Wejdan Kattuah;Claire Troakes;Tibor Hortobagyi;Boris Rogelj;Christopher Shaw
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
55.Endogenous TDP-43 but not FUS contributes to stress granule assembly via G3BP

机译：内源性TDP-43（而非FUS）通过G3BP促进应力颗粒的组装
- 作者：Anaïs Aulas;Stéphanie Stabile;Christine Vande Velde
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- TDP-43 Stress granules FUS/TLS G3BP TIA-1 ALS Cell death Oxidative stress;
56.In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells

机译：cJun N末端激酶抑制剂对视网膜神经节细胞的体外和体内神经保护作用
- 作者：Byung-Jin Kim;Sean M. Silverman;Yang Liu;Robert J. Wordinger;Iok-Hou Pang;Abbot F. Clark
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- Retinal ischemia c-Jun N-terminal kinase (JNK) Retinal ganglion cells JNK inhibitors Electroretinography;
57.Investigation of genetic variants regulating the expression of metabotropic glutamate receptor subtype 5 (GRM5) mRNA in human brain

机译：调节人脑代谢型谷氨酸受体5亚型（GRM5）mRNA表达的遗传变异研究
- 作者：Jian Wang;David Saffen
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
58.Regulation of Fe65 during neuronal differentiation

机译：Fe65在神经元分化过程中的调节
- 作者：Niina Koistinen;Kristin Jacobsen;Kerstin Iverfeldt
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
59.A brain-targeted modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

机译：在多系统萎缩的小鼠模型中以脑为靶点的修饰神经毒素（kallikrein-6）减少了α-突触核蛋白的积累
- 作者：Brian Spencer;Elvira Valera;Edward Rockenstein;Margarita Trejo-Morales;Anthony Adame;Eliezer Masliah
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
60.The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

机译：Trem2 R47H阿尔茨海默氏症的风险变异损害剪接并降低小鼠而非人类的Trem2 mRNA和蛋白质
- 作者：Xianyuan Xiang;Thomas M. Piers;Benedikt Wefers;Kaichuan Zhu;Anna Mallach;Bettina Brunner;Gernot Kleinberger;Wilbur Song;Marco Colonna;Jochen Herms;Wolfgang Wurst;Jennifer M. Pocock;Christian Haass
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Alzheimer’s disease Microglia Neurodegeneration TREM2 Pre-mRNA splicing Human microglia;
61.Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

机译：rTg4510小鼠中O-GlcNAcase的抑制导致O-GlcNAc tau升高以及tauopathy和脑脊液tau减少
- 作者：Nicholas B. Hastings;Xiaohai Wang;Lixin Song;Brent D. Butts;Diane Grotz;Richard Hargreaves;J. Fred Hess;Kwok-Lam Karen Hong;Cathy Ruey-Ruey Huang;Lynn Hyde;Maureen Laverty;Julie Lee;Diane Levitan;Sherry X. Lu;Maureen Maguire;Veeravan Mahadomrongkul;Ernest J. McEachern;Xuesong Ouyang;Thomas W. Rosahl;Harold Selnick;Michaela Stanton;Giuseppe Terracina;David J. Vocadlo;Ganfeng Wang;Joseph L. Duffy;Eric M. Parker;Lili Zhang
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Tau OGA O-GlcNAc Alzheimer’s disease Tauopathy Neurodegeneration;
62.Renin angiotensin system and gender differences in dopaminergic degeneration

机译：肾素血管紧张素系统和多巴胺能变性的性别差异
- 作者：Ana I Rodriguez-Perez;Rita Valenzuela;Belen Joglar;Pablo Garrido-Gil;Maria J Guerra;Jose L Labandeira-Garcia
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- angiotensin estrogen menopause NADPH-oxidase complex neurodegeneration oxidative stress Parkinson sex differences;
63.Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

机译：可溶性apoE /Aβ复合物：APOE4引起的AD风险的机制和治疗靶标
- 作者：Leon M Tai;Shipra Mehra;Varsha Shete;Steve Estus;G William Rebeck;Guojun Bu;Mary Jo LaDu
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Alzheimer’s disease Amyloid beta Apolipoprotein E Apolipoprotein E/amyloid beta complex Oligomeric amyloid beta Lipoprotein Lipidation;
64.Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells

机译：甲酰肽受体参与晚期糖基化终产物（RAGE）受体和淀粉样β1-42诱导的神经胶质细胞信号转导
- 作者：Alexander Slowik;Julika Merres;Anne Elfgen;Sandra Jansen;Fabian Mohr;Christoph J Wruck;Thomas Pufe;Lars-Ove Brandenburg
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Alzheimer disease Amyloid beta 1–42 S100B Formyl peptide receptor Glial cell Astrocytes Microglia RAGE Signal transduction;
65.Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain

机译：网络驱动的血浆蛋白质组学揭示了阿尔茨海默氏症大脑中的分子变化
- 作者：Philipp A. Jaeger;Kurt M. Lucin;Markus Britschgi;Badri Vardarajan;Ruo-Pan Huang;Elizabeth D. Kirby;Rachelle Abbey;Bradley F. Boeve;Adam L. Boxer;Lindsay A. Farrer;NiCole Finch;Neill R. Graff-Radford;Elizabeth Head;Matan Hoffree;Ruochun Huang;Hudson Johns;Anna Karydas;David S. Knopman;Andrey Loboda;Eliezer Masliah;Ramya Narasimhan;Ronald C. Petersen;Alexei Podtelezhnikov;Suraj Pradhan;Rosa Rademakers;Chung-Huan Sun;Steven G. Younkin;Bruce L. Miller;Trey Ideker;Tony Wyss-Coray
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
66.Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation

机译：5-脂氧合酶/半胱氨酰白三烯受体1参与鱼藤酮和MPP +诱导的BV2小胶质细胞活化
- 作者：Yanfang Wang;Xiaoyan Zhang;Chengtan Li;Jianbo Zhao;Erqing Wei;Lihui Zhang
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
67.Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging

机译：淀粉样蛋白前体蛋白家族成员在应激信号和衰老中的细胞保护功能
- 作者：Arpita Kundu;Andreas Zymny;Steffi Chang;Nelli Röhner;Donat Kögel
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
68.Mice lacking caspase-2 are protected from behavioral changes but not pathology in the YAC128 model of Huntington disease

机译：在亨廷顿病的YAC128模型中保护缺乏caspase-2的小鼠免受行为改变但不受病理影响
- 作者：Jeffrey B Carroll;Amber L Southwell;Rona K Graham;Jason P Lerch;Dagmar E Ehrnhoefer;Li-Ping Cao;Wei-Ning Zhang;Yu Deng;Nagat Bissada;R Mark Henkelman;Michael R Hayden
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Huntingtons Disease neurodegeneration caspase magnetic resonance imaging;
69.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

机译：纹状体内注射α-突触核蛋白可导致广泛的突触核病而与神经解剖学连接无关
- 作者：Zachary A. Sorrentino;Mieu M.T. Brooks;Vincent Hudson III;Nicola J. Rutherford;Todd E. Golde;Benoit I. Giasson;Paramita Chakrabarty
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- α-synuclein Amyloid Prion Striatum Dopaminergic Neurodegeneration Astrocyte;
70.Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

机译：通过靶向Pde6δ修饰Rap1信号转导在阿尔茨海默氏病模型中具有神经保护作用
- 作者：Michael Dumbacher;Tom Van Dooren;Katrien Princen;Koen De Witte;Mélissa Farinelli;Sam Lievens;Jan Tavernier;Wim Dehaen;Stefaan Wera;Joris Winderickx;Sara Allasia;Amuri Kilonda;Stéphane Spieser;Arnaud Marchand;Patrick Chaltin;Casper C. Hoogenraad;Gerard Griffioen
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Alzheimer’s disease Hyperexcitability Neuroprotection Pde6δ Rap1;
71.The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease

机译：RAB39B p.G192R突变导致X连锁显性帕金森氏病
- 作者：Ignacio F. Mata;Yongwoo Jang;Chun-Hyung Kim;David S. Hanna;Michael O. Dorschner;Ali Samii;Pinky Agarwal;John W. Roberts;Olga Klepitskaya;David R. Shprecher;Kathryn A. Chung;Stewart A. Factor;Alberto J. Espay;Fredy J. Revilla;Donald S. Higgins;Irene Litvan;James B. Leverenz;Dora Yearout;Miguel Inca-Martinez;Erica Martinez;Tiffany R. Thompson;Brenna A. Cholerton;Shu-Ching Hu;Karen L. Edwards;Kwang-Soo Kim;Cyrus P. Zabetian
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
72.Trafficking regulation of proteins in Alzheimer’s disease

机译：蛋白质在阿尔茨海默氏病中的调节作用
- 作者：Shangtong Jiang;Yanfang Li;Xian Zhang;Guojun Bu;Huaxi Xu;Yun-wu Zhang
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- α-secretase Amyloid beta (A4) precursor protein β-secretase Beta-site APP-cleaving enzyme 1 γ-secretase A Disintegrin and Metalloprotease 10 Alzheimer’s disease Trafficking;
73.Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

机译：改良的秀丽隐杆线虫的淀粉样β（Aβ1-42）毒性模型在筛选阿尔茨海默氏病药物中的用途
- 作者：Gawain McColl;Blaine R Roberts;Tara L Pukala;Vijaya B Kenche;Christine M Roberts;Christopher D Link;Timothy M Ryan;Colin L Masters;Kevin J Barnham;Ashley I Bush;Robert A Cherny
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Amyloid beta peptide Alzheimer’s disease Caenorhabditis elegans 8-hydroxyquinoline PBT2 and drug screen;
74.Tau mutant A152T a risk factor for FTD/PSP induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

机译：Tau突变体A152T是FTD / PSP的危险因素可诱导线粒体Tauopathy模型中的神经元功能障碍和寿命缩短而与聚集无关
- 作者：Ghulam Jeelani Pir;Bikash Choudhary;Eckhard Mandelkow;Eva-Maria Mandelkow
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
75.Alzheimer’s disease candidate gene PION is differentially expressed in human prefrontal cortex

机译：阿尔茨海默氏病候选基因PION在人类前额叶皮层中差异表达
- 作者：Min Zhu;David Saffen
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
76.Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

机译：阿尔茨海默氏病大脑的深层蛋白质组网络分析揭示了与疾病相关的RNA结合蛋白和RNA剪接的改变
- 作者：Erik C. B. Johnson;Eric B. Dammer;Duc M. Duong;Luming Yin;Madhav Thambisetty;Juan C. Troncoso;James J. Lah;Allan I. Levey;Nicholas T. Seyfried
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Alzheimer’s disease Proteomics Proteogenomics RNA binding protein RNA splicing;
77.Downregulation of CREB expression in Alzheimers brain and in Aβ-treated rat hippocampal neurons

机译：下调阿尔茨海默氏症和Aβ治疗的大鼠海马神经元中CREB表达的下调
- 作者：Subbiah Pugazhenthi;Maorong Wang;Serena Pham;Chun-I Sze;Christopher B Eckman
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Alzheimers disease CREB Oxidative stress Apoptosis Tg2576 mice Laser capture microdissection;
78.Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain

机译：使用腺相关病毒（AAV）载体在小鼠前脑中表达tau来解释tau在神经变性中的作用
- 作者：Aurélien Lathuilière;Stéphanie Papin;Matthias Cacquevel;Paolo Paganetti;Andreas Muhs;Graham Knott;Bernard Schneider;Patrick Aebischer
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
79.Phosphorylation of tau at Y18 but not tau-fyn binding is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

机译：tau在原代神经元培养物中调节NMDA受体依赖性兴奋性毒性需要Y18处的tau磷酸化而不是tau-fyn结合
- 作者：Takashi Miyamoto;Liana Stein;Reuben Thomas;Biljana Djukic;Praveen Taneja;Joseph Knox;Keith Vossel;Lennart Mucke
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Calcium Excitotoxicity Fyn NMDARs Phosphorylation Tau Y18;
80.Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

机译：乙草胺通过调节DAF-16 / FOXO靶基因表达改善神经退行性疾病的表型
- 作者：Xi Chen;Hannah V. McCueF;Shi Quan Wong;Sudhanva S. Kashyap;Brian C. Kraemer;Jeff W. Barclay;Robert D. Burgoyne;Alan Morgan
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Adult onset neuronal lipofuscinosis Frontotemporal dementia Neurodegeneration Aging Caenorhabditis elegans Neuroblastoma;
81.Ryanodine receptors: physiological function and deregulation in Alzheimer disease

机译：Ryanodine受体：阿尔茨海默病的生理功能和失调
- 作者：Dolores Del Prete;Frédéric Checler;Mounia Chami
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Ryanodine receptor Calcium Alzheimer disease Endoplasmic reticulum Neurodegeneration Presenilin Amyloid precursor protein Amyloid beta;
82.Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

机译：溶酶体蛋白水解缺陷和轴突运输是早期致病事件随着年龄的增长而恶化导致转基因APP / PS1海马中APP代谢增加和突触Abeta增加
- 作者：Manuel Torres;Sebastian Jimenez;Raquel Sanchez-Varo;Victoria Navarro;Laura Trujillo-Estrada;Elisabeth Sanchez-Mejias;Irene Carmona;Jose Carlos Davila;Marisa Vizuete;Antonia Gutierrez;Javier Vitorica
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- Alzheimer’s disease PS1/APP transgenic model Dystrophic neurites Tau phosphorylation. Cathepsin activity APP processing Abeta production;
83.A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer’s disease

机译：在多种家族性小鼠模型和新型偶发性阿尔茨海默氏病模型中进行疾病修饰的多功能治疗方法
- 作者：Jia Luo;Sue H. Lee;Lawren VandeVrede;Zhihui Qin;Manel Ben Aissa;John Larson;Andrew F. Teich;Ottavio Arancio;Yohan D’Souza;Ahmed Elharram;Kevin Koster;Leon M. Tai;Mary Jo LaDu;Brian M. Bennett;Gregory R. J. Thatcher
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- CREB activation NO/cGMP signaling CMZ NMZ Neuroprotection Alzheimer’s disease modifying approach Mixed pathology dementia AD mouse models Aldh2sup−/−/sup mice;
84.Neuroprotective effect of Curcumin involved in increasing the protein levels of UCP2 and inhibiting oxidative stress induced by chronic cerebral ischemia in vitro

机译：姜黄素的神经保护作用涉及增加UCP2的蛋白水平并抑制慢性脑缺血诱导的氧化应激
- 作者：Minna Gao;Li Liu;Peng Zhang;Gang Yu;Yu Li
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
85.ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

机译：ABI3和PLCG2错义变体是高加索人和非裔美国人神经退行性疾病的危险因素
- 作者：Olivia J Conway;Minerva M Carrasquillo;Xue Wang;Jenny M Bredenberg;Joseph S Reddy;Samantha L Strickland;Curtis S Younkin;Jeremy D Burgess;Mariet Allen;Sarah J Lincoln;Thuy Nguyen;Kimberly G Malphrus;Alexandra I Soto;Ronald L Walton;Bradley F Boeve;Ronald C Petersen;John A Lucas;Tanis J Ferman;William P Cheshire;Jay A van Gerpen;Ryan J Uitti;Zbigniew K Wszolek;Owen A Ross;Dennis W Dickson;Neill R Graff-Radford;Nilüfer Ertekin-Taner
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- ABI3 PLCG2 Alzheimer’s disease (AD) Progressive supranuclear palsy (PSP) Parkinson’s disease (PD) Dementia with Lewy bodies (DLB) Multiple system atrophy (MSA) African-American Genetic association Expression;
86.A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

机译：甘氨酸拉链基序在体内和体外介导有毒的β-淀粉样低聚物的形成
- 作者：Virginia Fonte;Vishantie Dostal;Christine M Roberts;Patrick Gonzales;Pascale Lacor;Jordi Magrane;Natalie Dingwell;Emily Y Fan;Michael A Silverman;Gretchen H Stein;Christopher D Link
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Alzheimers disease C. elegans pore-forming toxin glycine motif;
87.Analysis of in vivo turnover of tau in a mouse model of tauopathy

机译：在tauopathy小鼠模型中tau体内转换的分析。
- 作者：Kaoru Yamada;Tirth K. Patel;Katja Hochgräfe;Thomas E. Mahan;Hong Jiang;Floy R. Stewart;Eva-Maria Mandelkow;David M. Holtzman
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Alzheimer’s disease Clearance Half-life Extracellular tau Tauopathy model;
88.Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

机译：帕金森氏病和多系统萎缩症的自身免疫抗体下降；迈向免疫治疗策略的一步
- 作者：Tomasz Brudek;Kristian Winge;Jonas Folke;Søren Christensen;Karina Fog;Bente Pakkenberg;Lars Østergaard Pedersen
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Parkinson’s disease Multiple System Atrophy Alpha-synuclein Synuclein Autoantibodies Plasma;
89.Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation

机译：鉴定抑制tau过度磷酸化的微管亲和力调节激酶的有效抑制剂
- 作者：Alison Levy;Michelle Newman;Janet Brownlees;Denise Harding;Joanne Osborne;Stephen Lewis;Kevin Gillen;Gareth Hall;Chido Mpamhanga;Andy Merritt;Debra Taylor;Ed Mclver
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
90.Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease

机译：成人神经干细胞的表观遗传调控：对阿尔茨海默氏病的影响
- 作者：Carlos P Fitzsimons;Emma van Bodegraven;Marijn Schouten;Roy Lardenoije;Konstantinos Kompotis;Gunter Kenis;Mark van den Hurk;Marco P Boks;Caroline Biojone;Samia Joca;Harry WM Steinbusch;Katie Lunnon;Diego F Mastroeni;Jonathan Mill;Paul J Lucassen;Paul D Coleman;Daniel LA van den Hove;Bart PF Rutten
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- Adult neurogenesis Epigenetics Alzheimer’s disease DNA methylation Histone modifications MicroRNAs Stem cell Induced pluripotent stem cell;
91.Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

机译：Caspase-9介导丹麦痴呆敲入小鼠的突触可塑性和记忆缺陷：caspase-9抑制提供治疗性保护
- 作者：Robert Tamayev;Nsikan Akpan;Ottavio Arancio;Carol M Troy;Luciano D’Adamio
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
92.Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

机译：酪蛋白激酶-1δ抑制剂靶向TDP-43磷酸化：一种治疗额颞痴呆的新策略
- 作者：Carolina Alquezar;Irene G. Salado;Ana de la Encarnación;Daniel I. Pérez;Fermín Moreno;Carmen Gil;Adolfo López de Munain;Ana Martínez;Ángeles Martín-Requero
- 期刊名称：《Molecular Neurodegeneration》 | 2016年第-1期
- FTLD-TDP Lymphocytes Cell proliferation TDP-43 CK-1δ CDK6;
93.Testosterone regulates Arp2/3 expression by DNA methylation in hippocampus

机译：睾丸激素通过海马中的DNA甲基化调节Arp2 / 3表达
- 作者：Liang Zhou;Ximeng Zhang;Xuefei Wu;Huan Yang;Kaiyin Zhong;Hecheng Wang;Ting Zhou;Tianxiao Sheng;Yawei Tong;Dongsheng Fan;Dehua Chui
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第Suppl 1期
94.Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimers disease suggests a role for rs3846662 and HMGCR splicing in disease risk

机译：胆固醇相关多态性与阿尔茨海默氏病之间全球关联性的评估表明rs3846662和HMGCR剪接在疾病风险中的作用
- 作者：Christopher R Simmons;Fanggeng Zou;Steven G Younkin;Steven Estus
- 期刊名称：《Molecular Neurodegeneration》 | 2011年第-1期
- Alzheimer genetics cholesterol GWAS SNP HMGCR statin;
95.Dysregulation of protein trafficking in neurodegeneration

机译：神经变性中蛋白质运输的失调。
- 作者：Xin Wang;Timothy Huang;Guojun Bu;Huaxi Xu
- 期刊名称：《Molecular Neurodegeneration》 | 2014年第-1期
- β-amyloid precursor protein β-secretase γ-secretase Sorting nexin The retromer complex Ras-related GTP-binding protein Alzheimer’s disease Down syndrome Parkinson’s disease Endocytic trafficking;
96.A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

机译：C9ORF72 BAC小鼠模型概括了ALS / FTD的关键表观遗传扰动
- 作者：Rustam Esanov;Gabriela Toro Cabrera;Nadja S. Andrade;Tania F. Gendron;Robert H. Brown Jr.;Michael Benatar;Claes Wahlestedt;Christian Mueller;Zane Zeier
- 期刊名称：《Molecular Neurodegeneration》 | 2017年第-1期
- Amyotrophic lateral sclerosis C9ORF72 BAC mouse Induced pluripotent stem cells DNA methylation Hydroxymethylation R-loops;
97.Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

机译：他汀类药物通过基于自噬的非常规分泌途径诱导星形胶质细胞分泌胰岛素降解酶
- 作者：Sung Min Son;Seokjo Kang;Heesun Choi;Inhee Mook-Jung
- 期刊名称：《Molecular Neurodegeneration》 | 2015年第-1期
- Statin Insulin-degrading enzyme (IDE) Autophagy-based unconventional secretion Amyloid-β (Aβ) Alzheimer’s disease (AD);
98.Amyloid-β drives a type-1 interferon mediated neuro-inflammatory response in Alzheimer’s disease

机译：淀粉样蛋白β驱动阿尔茨海默氏病的1型干扰素介导的神经炎症反应
- 作者：Myles Minter;Juliet Taylor;Moses Zhang;Paul Adlard;Peter Crack
- 期刊名称：《Molecular Neurodegeneration》 | 2013年第Suppl 1期
99.Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

机译：淀粉样β或TAU病理学诱导的神经元miRNA失调
- 作者：Annerieke Sierksma;Ashley Lu;Evgenia Salta;Elke Vanden Eynden;Zsuzsanna Callaerts-Vegh;Rudi D’Hooge;David Blum;Luc Buée;Mark Fiers;Bart De Strooper
- 期刊名称：《Molecular Neurodegeneration》 | 2018年第-1期
- Alzheimer’s disease microRNA miRNA-seq In situ hybridization miR-mimic;
100.Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

机译：EVP-0015962对γ-分泌酶的调节减少了Tg2576小鼠的淀粉样蛋白沉积和行为缺陷
- 作者：Kathryn Rogers;Kevin M Felsenstein;Lori Hrdlicka;Zhiming Tu;Faris Albayya;Winnie Lee;Sarah Hopp;Mary-Jo Miller;Darcie Spaulding;Zhiyong Yang;Hilliary Hodgdon;Scott Nolan;Melody Wen;Don Costa;Jean-Francois Blain;Emily Freeman;Bart De Strooper;Veerle Vulsteke;Louise Scrocchi;Henrik Zetterberg;Erik Portelius;Birgit Hutter-Paier;Daniel Havas;Michael Ahlijanian;Dorothy Flood;Liza Leventhal;Gideon Shapiro;Holger Patzke;Richard Chesworth;Gerhard Koenig
- 期刊名称：《Molecular Neurodegeneration》 | 2012年第-1期
- γ-secretase Modulation NSAID Cognition Amyloid Alzheimer’s disease;

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