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JACC: Basic to Translational Science

【机译】：JaCC：从基础到转化科学

ISSN：-
出版周期：Seven times a year
语言：English

起始发布年份：2016
出版者：[New York] : Elsevier on behalf of the American College of Cardiology Foundation,
出版地：United States

NLM刊名缩写：JACC Basic Transl Sci

数据库引入：PubMed: v1n1-2, 2016-, PMC

MeSH词表主题词：Translational Medical Research*

备注：Some issues combined. Numbering from archive of all online content page.展开▼

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1.Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia

机译：与载脂蛋白E2基因型相关的脂蛋白（a）减少赋予家族性高胆固醇血症的心血管保护
- 作者：Valentin Blanchard;Mikaël Croyal;Ilya Khantalin;Stéphane Ramin-Mangata;Kévin Chemello;Brice Nativel;Dirk. J. Blom;A. David Marais;Gilles Lambert
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第3期
2.Circulating Pro-Vascular Progenitor Cell Depletion During Type 2 Diabetes

机译：2型糖尿病期间循环前血管祖细胞的消耗
- 作者：Daniella C. Terenzi;Mohammed Al-Omran;Adrian Quan;Hwee Teoh;Subodh Verma;David A. Hess
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
3.Phase II Trials in Drug Development and Adaptive Trial Design

机译：药物开发和适应性试验设计的第二阶段试验
- 作者：Gail A. Van Norman
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第3期
4.Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway

机译：Depteptidyl Peptidase-4抑制作用通过增强胰岛素样生长因子-1信号通路来预防血管钙化
- 作者：Olivier Varennes;Aurélien Mary;Giampiero Bricca;Saïd Kamel;Jeremy Bellien
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
5.Emerging Therapeutics for the Treatment of Light Chain and Transthyretin Amyloidosis

机译：新兴治疗轻链和运甲状腺素蛋白淀粉样变性的疗法
- 作者：Kathleen W. Zhang;Keith E. Stockerl-Goldstein;Daniel J. Lenihan
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第3期
6.Chest Compressions During Sustained Inflation During Cardiopulmonary Resuscitation in Newborn Infants Translating Evidence From Animal Studies to the Bedside

机译：新生婴儿心肺复苏期间持续通气期间的胸部按压将动物研究的证据转移到床边
- 作者：Georg M. Schmölzer
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
7.Fibroblasts in the Infarcted Remodeling and Failing Heart

机译：梗死重塑和心脏衰竭的成纤维细胞
- 作者：Claudio Humeres;Nikolaos G. Frangogiannis
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第3期
8.Therapeutic Genome Editing in Cardiovascular Diseases

机译：心血管疾病的治疗基因组编辑
- 作者：David M. German;Shoukhrat Mitalipov;Anusha Mishra;Sanjiv Kaul
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
9.Q4 Vital Signs

机译：Q4生命体征
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第3期
10.What Are the Off-Target Effects of Plan S For Translational Investigators?

机译：计划 S对翻译研究人员的脱靶效应是什么？
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
11.Correction

机译：更正
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第1期
12.Development and Validation of a Novel Cuff-Less Blood Pressure Monitoring Device

机译：新型无袖血压监测装置的开发和验证
- 作者：Naoki Watanabe;Yasuko K. Bando;Taiji Kawachi;Hiroshi Yamakita;Kouki Futatsuyama;Yoshikazu Honda;Hisae Yasui;Kazuyuki Nishimura;Takahiro Kamihara;Takahiro Okumura;Hideki Ishii;Takahisa Kondo;Toyoaki Murohara
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
13.Percutaneous Sampling of Local Biomolecule Gradients Across Coronary Artery Atherosclerotic Plaques

机译：跨冠状动脉粥样硬化斑块局部生物分子梯度的经皮采样。
- 作者：Nick E.J. West;Joseph P. Corrigan;Richard H.G. Owen;Stephen P. Hoole;Adam J. Brown;Stephen Blatcher;Andrew C. Newby
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
14.The Slow Evolution of Blood Pressure Monitoring

机译：血压监测的缓慢发展
- 作者：Florian Rader;Ronald G. Victor
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
15.Is Protein Kinase C Inhibition the Tip of the Iceberg in New Therapeutics for Acutely Decompensated Heart Failure?

机译：蛋白激酶C抑制是急性失代偿性心力衰竭新疗法中的冰山一角吗？
- 作者：David R. Pimental;Flora Sam
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
16.Cardiac Macrophages Reactive Oxygen Species and Development of Left Ventricular Dysfunction

机译：心脏巨噬细胞活性氧种类和左心室功能障碍的发展
- 作者：Yiming Wang;Slava Epelman
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
17.Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction

机译：实验性急性心肌梗死后LCZ696（Sa屈/缬沙坦）的心脏保护作用
- 作者：Masanobu Ishii;Koichi Kaikita;Koji Sato;Daisuke Sueta;Koichiro Fujisue;Yuichiro Arima;Yu Oimatsu;Tatsuro Mitsuse;Yoshiro Onoue;Satoshi Araki;Megumi Yamamuro;Taishi Nakamura;Yasuhiro Izumiya;Eiichiro Yamamoto;Sunao Kojima;Shokei Kim-Mitsuyama;Hisao Ogawa;Kenichi Tsujita
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
18.Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

机译：Ruboxistaurin对蛋白激酶C的抑制作用可在射血分数降低的心衰猪模型中增加收缩力并减小心脏大小
- 作者：Thomas E. Sharp III;Hajime Kubo;Remus M. Berretta;Timothy Starosta;Markus Wallner;Giana J. Schena;Alexander R. Hobby;Daohai Yu;Danielle M. Trappanese;Jon C. George;Jeffery D. Molkentin;Steven R. Houser
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
19.NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling

机译：NADPH氧化酶4驱动的心脏巨噬细胞极化可防止心肌梗塞诱发的重塑
- 作者：Heloise Mongue-Din;Ashish S. Patel;Yee H. Looi;David J. Grieve;Narayana Anilkumar;Alexander Sirker;Xuebin Dong;Alison C. Brewer;Min Zhang;Alberto Smith;Ajay M. Shah
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
20.Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury

机译：老化的人多能间质基质细胞可通过神经元衍生的神经营养因子恢复活力并改善损伤后的心脏功能
- 作者：Hui-Fang Song;Sheng He;Shu-Hong Li;Wen-Juan Yin;Jun Wu;Jian Guo;Zheng-Bo Shao;Xiao-Yan Zhai;Hui Gong;Li Lu;Fang Wei;Richard D. Weisel;Jun Xie;Ren-Ke Li
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
21.Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

机译：同种异体PW1pos / Pax7neg间质细胞的移植增强了猪骨骼肌损伤的内源性修复
- 作者：Fiona C. Lewis;Beverley J. Cottle;Victoria Shone;Giovanna Marazzi;David Sassoon;Cheyenne C.S. Tseng;Patricia Y.W. Dankers;Steven A.J. Chamuleau;Bernardo Nadal-Ginard;Georgina M. Ellison-Hughes
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
22.Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models

机译：通过增加儿茶酚胺能性心动过速模型中线粒体Ca2 +的摄取来抑制心律失常
- 作者：Maria K. Schweitzer;Fabiola Wilting;Simon Sedej;Lisa Dreizehnter;Nathan J. Dupper;Qinghai Tian;Alessandra Moretti;Ilaria My;Ohyun Kwon;Silvia G. Priori;Karl-Ludwig Laugwitz;Ursula Storch;Peter Lipp;Andreas Breit;Michael Mederos y Schnitzler;Thomas Gudermann;Johann Schredelseker
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
23.Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

机译：超声微泡空化术治疗导管插入性血管痉挛
- 作者：Shelby Kutty;Na Liu;Jia Zhou;Yunbin Xiao;Juefei Wu;David A. Danford;John Lof;Feng Xie;Thomas R. Porter
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
24.Molecular Epidemiology of Heart Failure

机译：心力衰竭的分子流行病学
- 作者：J. Gustav Smith
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
25.Murine Models of Heart Failure With Preserved Ejection Fraction

机译：保留射血分数的心力衰竭小鼠模型
- 作者：Maria Valero-Muñoz;Warren Backman;Flora Sam
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
26.Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease

机译：内皮细胞和免疫细胞衍生的细胞外小泡在心血管健康和疾病的调节中
- 作者：Felix Jansen;Qian Li;Alexander Pfeifer;Nikos Werner
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
27.Truth and Truthiness in Translational Research

机译：翻译研究中的真理与真理
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2017年第6期
28.Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

机译：原发性二尖瓣关闭不全的病理生理学中左心房排空分数和胰酶活化的降低
- 作者：Brittany Butts;Mustafa I. Ahmed;Navkaranbir S. Bajaj;Pamela Cox Powell;Betty Pat;Silvio Litovsky;Himanshu Gupta;Steven G. Lloyd;Thomas S. Denney;Xiaoxia Zhang;Inmaculada Aban;Sakthivel Sadayappan;James W. McNamara;Michael J. Watson;Carlos M. Ferrario;James F. Collawn;Clifton Lewis;James E. Davies;Louis J. Dell’Italia
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- chymase;
- fibrosis;
- left atrium;
- left ventricle;
- mitral regurgitation;
- mitral valve;
29.A New Chapter in the Biology of Mitral Regurgitation as Told by the Left Atrium

机译：左心房诉说的二尖瓣反流生物学的新篇章
- 作者：Blase A. Carabello
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- chymase;
- left atrium;
- mitral regurgitation;
30.Deletion of Socs3 Expression in Aortic Smooth Muscle Cells Ameliorates Aortic Dissection

机译：删除主动脉平滑肌细胞中的Socs3表达可改善主动脉夹层
- 作者：Michael P. Murphy;Justin R. King;Katherin E. Leckie
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- aortic dissection;
- inflammation;
- Jak/Stat;
- smooth muscle cells;
31.Paracrine Factors in Uremic Cardiomyopathy

机译：尿毒症心肌病的旁分泌因子
- 作者：Carmen C. Sucharov
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- exosome;
- miRNA;
- pyroptosis;
- uremic cardiomyopathy;
32.Are the Cardiorenal Benefits of SGLT2 Inhibitors Due to Inhibition of the Sympathetic Nervous System?

机译：SGLT2抑制剂的心脏肾益处是否归因于交感神经系统的抑制？
- 作者：Subodh Verma
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- cardiorenal benefits;
- mechanisms;
- SGLT2 inhibitors;
- sympathetic nervous system;
33.The Importance of Overcoming Resistance

机译：克服抵抗的重要性
- 作者：Norman A. Paradis
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- coronary perfusion pressure;
- CPR;
- lactic acid;
- pulmonary vasodilation;
- sodium nitroprusside;
34.Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

机译：平滑肌细胞中Socs3的基因缺失改善了小鼠的主动脉夹层
- 作者：Saki Hirakata;Hiroki Aoki;Satoko Ohno-Urabe;Michihide Nishihara;Aya Furusho;Norifumi Nishida;Sohei Ito;Makiko Hayashi;Hideo Yasukawa;Tsutomu Imaizumi;Sinichi Hiromatsu;Hiroyuki Tanaka;Yoshihiro Fukumoto
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- aortic dissection;
- inflammation;
- Jak/Stat;
- smooth muscle cells;
35.Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy

机译：巨噬细胞源性Mir-155调节尿毒症性心肌病心肌细胞的焦磷酸化和肥大
- 作者：Bin Wang;Ze-Mu Wang;Jia-Ling Ji;Weihua Gan;Aiqing Zhang;Hao-Jie Shi;Hao Wang;Linli Lv;Zuolin Li;Taotao Tang;Jie Du;Xiaonan H. Wang;Bi-Cheng Liu
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- exosome;
- FoxO3a;
- miR-155;
- pyroptosis;
- uremic cardiomyopathy;
36.SGLT2 Inhibitor–Induced Sympathoinhibition

机译：SGLT2抑制剂诱导的交感神经抑制
- 作者：Lakshini Y. Herat;Aaron L. Magno;Caroline Rudnicka;Jana Hricova;Revathy Carnagarin;Natalie C. Ward;Angelique Arcambal;Marcio G. Kiuchi;Geoff A. Head;Markus P. Schlaich;Vance B. Matthews
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- denervation;
- heart;
- hypertension;
- kidney;
- SGLT2;
- sympathetic nervous system;
37.Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements

机译：硝普钠加强心肺复苏可通过肺血管舒张改善血流导致更高的氧气需求
- 作者：Adrian Ripeckyj;Marinos Kosmopoulos;Kadambari Shekar;Claire Carlson;Rajat Kalra;Jennifer Rees;Tom P. Aufderheide;Jason A. Bartos;Demetris Yannopoulos
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- cardiopulmonary resuscitation;
- coronary perfusion pressure;
- lactic acid;
- pulmonary vasodilation;
- sodium nitroprusside;
38.Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure

机译：克隆性造血：将炎症与心脏衰竭联系起来的新步骤
- 作者：Yoshimitsu Yura;Soichi Sano;Kenneth Walsh
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
- DNMT3A;
- Il-1β inflammasome;
- JAK2;
- TET2;
- TNF-α;
39.Intracoronary Delivery of Mitochondria to Prevent Ischemia–Reperfusion Injury

机译：冠状动脉内线粒体预防缺血再灌注损伤
- 作者：Alberto Aimo;Michele Emdin;Claudio Passino
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
40.Reply

机译：回复
- 作者：James D. McCully;Sitaram M. Emani;Pedro J. del Nido
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第2期
41.Comparative Transcriptomics of Ex Vivo Patient-Derived Endothelial Cells Reveals Novel Pathways Associated With Type 2 Diabetes Mellitus

机译：前体外患者来源的内皮细胞的比较转录组学揭示了与2型糖尿病相关的新途径
- 作者：Joshua A. Beckman;Sean P. Doherty;Zachary B. Feldman;Emily S. Banks;Javid Moslehi;Iris Z. Jaffe;Naomi M. Hamburg;Quanhu Sheng;Jonathan D. Brown
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- endothelial cells;
- gene expression;
- diabetes mellitus;
- endothelial cell dysfunction;
42.Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin

机译：炎症削弱了心肌微血管内皮细胞的增强作用依帕列净可恢复其功能
- 作者：Rio P. Juni;Diederik W.D. Kuster;Max Goebel;Michiel Helmes;René J.P. Musters;Jolanda van der Velden;Pieter Koolwijk;Walter J. Paulus;Victor W.M. van Hinsbergh
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- contraction and relaxation;
- endothelial cell–derived nitric oxide;
- empagliflozin;
- heart failure;
- oxidative stress;
43.Platelet Acetyl-CoA Carboxylase Phosphorylation

机译：血小板乙酰辅酶A羧化酶磷酸化
- 作者：Shakeel Kautbally;Sophie Lepropre;Marie-Blanche Onselaer;Astrid Le Rigoleur;Audrey Ginion;Christophe De Meester de Ravenstein;Jerome Ambroise;Karim Z. Boudjeltia;Marie Octave;Odile Wéra;Alexandre Hego;Joël Pincemail;Jean-Paul Cheramy-Bien;Thierry Huby;Martin Giera;Bernhard Gerber;Anne-Catherine Pouleur;Bruno Guigas;Jean-Louis Vanoverschelde;Joelle Kefer;Luc Bertrand;Cécile Oury;Sandrine Horman;Christophe Beauloye
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- AMPK;
- acetyl-CoA carboxylase;
- coronary artery disease;
- lipidomics;
- platelet;
44.Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

机译：是相关蛋白（YAP）促进糖尿病心脏压力超负荷引起的功能障碍
- 作者：Shohei Ikeda;Risa Mukai;Wataru Mizushima;Peiyong Zhai;Shin-ichi Oka;Michinari Nakamura;Dominic P. Del Re;Sebastiano Sciarretta;Chiao-Po Hsu;Hiroaki Shimokawa;Junichi Sadoshima
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- diabetes;
- diabetic cardiomyopathy;
- Hippo pathway;
- pressure overload;
45.Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

机译：酒精暴饮诱发的心血管功能障碍涉及内源性大麻素–CB1-R信号传导
- 作者：Janos Paloczi;Csaba Matyas;Resat Cinar;Zoltan V. Varga;György Hasko;Thomas H. Schindler;George Kunos;Pal Pacher
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- binge alcohol drinking;
- cannabinoids;
- contractility;
- endocannabinoids;
46.Empagliflozin and Protecting Microvascular Support of Heart Mechanics

机译：依帕列净和保护心脏机械的微血管支持
- 作者：Chris Sorel Mantsounga;Alan R. Morrison
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- cardiomyocyte;
- empagliflozin;
- endothelial cell;
- heart failure;
- microvasculature;
47.The Hippo in the Clinic

机译：河马在诊所
- 作者：Sheldon H. Gottlieb
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- diabetes;
- diastolic heart failure;
- Hippo pathway;
- mouse model metabolic syndrome;
- Yes-associated protein (YAP);
48.The Detrimental Effects of Alcohol and Cannabinoids on Cardiovascular Function

机译：酒精和大麻素对心血管功能的有害影响
- 作者：Fabrizio Montecucco;Federico Carbone
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- alcohol;
- cardiovascular dysfunction;
- endocannabinoids;
49.Atrial Myopathy

机译：心房肌病
- 作者：Mark J. Shen;Rishi Arora;José Jalife
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
- atrial fibrillation;
- atrial myopathy;
- electrophysiology;
- thrombosis;
50.Current Education of Physicians: Lost in Translation?

机译：当前的医师教育：迷失在翻译中？
- 作者：Andrew I. Schafer;Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第5期
51.A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy

机译：一种通过冠状动脉线粒体递送保护心肌的新型生物策略：安全性和有效性
- 作者：Borami Shin;Mossab Y. Saeed;Jesse J. Esch;Alvise Guariento;David Blitzer;Kamila Moskowitzova;Giovanna Ramirez-Barbieri;Arzoo Orfany;Jerusha K. Thedsanamoorthy;Douglas B. Cowan;James A. Inkster;Erin R. Snay;Steven J. Staffa;Alan B. Packard;David Zurakowski;Pedro J. del Nido;James D. McCully
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- ischemia-reperfusion injury;
- mitochondria;
- mitochondrial transplantation;
- myocardial protection;
52.Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

机译：白细胞介素5与斑块形成和心血管事件的关系
- 作者：Anki Knutsson;Harry Björkbacka;Pontus Dunér;Gunnar Engström;Christoph J. Binder;Anna Hultgårdh Nilsson;Jan Nilsson
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- interleukin 5;
- atherosclerosis;
- myocardial infarction;
- stroke;
53.Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

机译：通过长期口服甲酰肽受体激动剂治疗可保护梗死后心脏的结构和功能
- 作者：Ricardo A. García;Bruce R. Ito;John A. Lupisella;Nancy A. Carson;Mei-Yin Hsu;Gayani Fernando;Madeleine Heroux;Michel Bouvier;Elizabeth Dierks;Ellen K. Kick;David A. Gordon;Jian Chen;Gabe Mintier;Marilyn Carrier;Stéphane St-Onge;Himanshu Shah;Jordan Towne;Marcela Sotelo Bucardo;Xiuying Ma;Carol S. Ryan;Nicholas R. Wurtz;Jacek Ostrowski;Francisco J. Villarreal
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- agonist;
- Compound 43;
- formyl peptide receptor;
- heart failure;
- myocardial infarction;
54.Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction

机译：Seipin基因敲除小鼠通过保留射血分数导致心力衰竭
- 作者：Bo Bai;Wulin Yang;Yanyun Fu;Hannah Lee Foon;Wan Ting Tay;Kangmin Yang;Cuiting Luo;Jayantha Gunaratne;Philip Lee;Michael R. Zile;Aimin Xu;Calvin W.L. Chin;Carolyn S.P. Lam;Weiping Han;Yu Wang
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- fibrosis;
- heart failure with preserved ejection fraction;
- neutrophil;
- seipin;
- titin;
55.Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP

机译：PDEV抑制和BNP对临床前收缩期功能障碍的容量扩大的心脏对肾脏的反应
- 作者：Siu-Hin Wan;Isabel Torres-Courchoud;Paul M. McKie;Joshua P. Slusser;Margaret M. Redfield;John C. Burnett;Jr.;David O. Hodge;Horng H. Chen
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- B-type natriuretic peptide;
- cardiorenal;
- heart failure;
- nesiritide;
- phosphodiesterase inhibition;
- systolic dysfunction;
56.The New Promise of Mitochondrial Transplantation for Myocardial Recovery

机译：线粒体移植对心肌恢复的新承诺
- 作者：W.H. Wilson Tang
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- coronary blood flow;
- heart failure;
- ischemic-reperfusion;
- mitochondrial transplant;
57.Interleukin 5 Contributes to Human Atherosclerosis Development But not to Thrombotic Complications

机译：白介素5有助于人类动脉粥样硬化的发展但不有助于血栓形成并发症。
- 作者：Hafid Ait-Oufella;Soraya Taleb;Alain Tedgui
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- atherosclerosis;
- interleukin 5;
- myocardial infarction;
- stroke;
58.Therapeutic Treatment Approaches Post–Myocardial Infarction

机译：心肌梗死后的治疗方法
- 作者：Rysa Zaman;Slava Epelman
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- formyl peptide receptor;
- macrophages;
- monocytes;
- myocardial infarction;
59.The Bslc2–/– Mouse

机译：Bslc2 – / –鼠标
- 作者：Fadi N. Salloum;Stefano Toldo
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- HFpEF;
- lean diabetic;
- seipin;
60.CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

机译：CFTR治疗药物可正常化小鼠心力衰竭和蛛网膜下腔出血模型的脑灌注不足
- 作者：Darcy Lidington;Jessica C. Fares;Franziska E. Uhl;Danny D. Dinh;Jeffrey T. Kroetsch;Meghan Sauvé;Firhan A. Malik;Frank Matthes;Lotte Vanherle;Arman Adel;Abdul Momen;Hangjun Zhang;Roozbeh Aschar-Sobbi;Warren D. Foltz;Hoyee Wan;Manabu Sumiyoshi;R. Loch Macdonald;Mansoor Husain;Peter H. Backx;Scott P. Heximer;Anja Meissner;Steffen-Sebastian Bolz
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
61.Targeting Muscles in the Brain to Enhance Cerebral Perfusion

机译：靶向大脑中的肌肉以增强脑灌注
- 作者：Jin-Moo Lee;Abhinav Diwan;Gregory J. Zipfel
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
62.Paradoxical Cardiorenal Responses Following Acute Vasodilator/Natriuretic Treatment in Presystolic Heart Failure

机译：收缩期前心衰患者急性血管扩张剂/钠尿治疗后心肾反应异常
- 作者：Tamar S. Polonsky;George L. Bakris
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- glomerular filtration rate;
- natriuresis;
- nesiritide;
- systolic heart failure;
63.Epigenetics in Cardiac Hypertrophy and Heart Failure

机译：心脏肥大和心脏衰竭的表观遗传学
- 作者：Chia-Feng Liu;W.H. Wilson Tang
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
- cardiac hypertrophy;
- epigenetics;
- heart failure;
64.Correction

机译：更正
- 期刊名称：《JACC: Basic to Translational Science》 | 2019年第8期
65.Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial

机译：β3-肾上腺素能激动剂治疗心力衰竭继发性慢性肺动脉高压的设计
- 作者：Ines Garcia-Lunar;Isabel Blanco;Leticia Fernández-Friera;Susanna Prat-Gonzàlez;Paloma Jordà;Javier Sánchez;Daniel Pereda;Sandra Pujadas;Mercedes Rivas;Eduard Solé-Gonzalez;Jorge Vázquez;Zorba Blázquez;Juan García-Picart;Pedro Caravaca;Noemí Escalera;Pablo Garcia-Pavia;Juan Delgado;Javier Segovia-Cubero;Valentín Fuster;Eulalia Roig;Joan Albert Barberá;Borja Ibanez;Ana García-Álvarez
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- adrenoreceptors;
- imaging;
- pulmonary hypertension;
- treatment;
66.In Situ Immune Profiling of Heart Transplant Biopsies Improves Diagnostic Accuracy and Rejection Risk Stratification

机译：心脏活检的原位免疫分析可提高诊断准确性和排斥风险分层
- 作者：Eliot G. Peyster;Chichung Wang;Felicia Ishola;Bethany Remeniuk;Clifford Hoyt;Michael D. Feldman;Kenneth B. Margulies
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- allograft rejection;
- immune checkpoint molecules;
- immune regulation;
- quantitative immunohistochemistry;
67.Immune Cell Profiling and Risk Stratification

机译：免疫细胞分析和风险分层
- 作者：M. Elizabeth H. Hammond
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- allograft rejection;
- immune checkpoint molecules;
- immune regulation;
- quantitative immunohistochemistry;
68.Shining a Light on Venous Thromboembolism

机译：照亮静脉血栓栓塞
- 作者：Yogendra Kanthi;Aditya Sharma
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- animal models;
- coagulation;
- deep vein thrombosis;
- pulmonary embolism;
- venous thrombosis;
69.Targeting Phosphorylcholine in Established Atherosclerosis?

机译：针对已建立的动脉粥样硬化的磷酸胆碱？
- 作者：Dimitrios Tsiantoulas
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- atherosclerosis;
- coronary flow reserve;
- inflammation;
70.In Vivo Imaging of Venous Thrombus and Pulmonary Embolism Using Novel Murine Venous Thromboembolism Model

机译：使用新型小鼠静脉血栓栓塞模型进行静脉血栓和肺栓塞的活体成像
- 作者：Mitsumasa Okano;Tetsuya Hara;Makoto Nishimori;Yasuhiro Irino;Seimi Satomi-Kobayashi;Masakazu Shinohara;Ryuji Toh;Farouc A. Jaffer;Tatsuro Ishida;Ken-ichi Hirata
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- 2-photon microscopy;
- deep vein thrombosis;
- imaging;
- pulmonary embolism;
- venous thromboembolism;
71.Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

机译：抗磷酸胆碱的治疗性抗体可保留冠状动脉功能并减轻动脉粥样硬化小鼠的血管18F-FDG摄取。
- 作者：Mia Ståhle;Johanna M.U. Silvola;Sanna Hellberg;Margreet de Vries;Paul H.A. Quax;Jeffrey Kroon;Petteri Rinne;Alwin de Jong;Heidi Liljenbäck;Nina Savisto;Anna Wickman;Erik S.G. Stroes;Seppo Ylä-Herttuala;Pekka Saukko;Tommy Abrahamsson;Knut Pettersson;Juhani Knuuti;Anne Roivainen;Antti Saraste
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- atherosclerosis;
- coronary flow reserve;
- inflammation;
72.Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

机译：系统分析将WAVE2复合物牵连到发育性左侧梗阻性心脏缺陷的发病机理中
- 作者：Jonathan J. Edwards;Andrew D. Rouillard;Nicolas F. Fernandez;Zichen Wang;Alexander Lachmann;Sunita S. Shankaran;Brent W. Bisgrove;Bradley Demarest;Nahid Turan;Deepak Srivastava;Daniel Bernstein;John Deanfield;Alessandro Giardini;George Porter;Richard Kim;Amy E. Roberts;Jane W. Newburger;Elizabeth Goldmuntz;Martina Brueckner;Richard P. Lifton;Christine E. Seidman;Wendy K. Chung;Martin Tristani-Firouzi;H. Joseph Yost;Avi Ma’ayan;Bruce D. Gelb
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- congenital heart disease;
- systems biology;
- translational genomics;
73.Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

机译：动物研究在临床试验中预测毒性的局限性
- 作者：Gail A. Van Norman
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- animal research;
- drug development;
- toxicity;
- translational research;
74.Targeting Vascular Calcification in Chronic Kidney Disease

机译：针对慢性肾脏疾病的血管钙化
- 作者：Adam J. Nelson;Paolo Raggi;Myles Wolf;Alexander M. Gold;Glenn M. Chertow;Matthew T. Roe
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
- chronic kidney disease;
- dialysis;
- medial calcification;
- vascular calcification;
75.JACC: Basic to Translational Science 2019 Young Author Award Winner

机译：JACC：基础科学与转化科学2019青年作者奖获得者
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
76.JACC: Basic to Translational Science 2019 Young Author Award Winner

机译：JACC：基础科学与转化科学2019青年作者奖获得者
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
77.Chinese Health Care Workers and COVID-19

机译：中国医护人员和COVID-19
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第4期
78.Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction

机译：保留射血分数的心衰患者氧利用的周围决定因素
- 作者：Payman Zamani;Elizabeth A. Proto;Jeremy A. Mazurek;Stuart B. Prenner;Kenneth B. Margulies;Raymond R. Townsend;Daniel P. Kelly;Zoltan Arany;David C. Poole;Peter D. Wagner;Julio A. Chirinos
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- adiposity;
- aerobic capacity;
- exercise;
- HFpEF;
- oxygen transport;
79.Decoding the Pathophysiology of HFpEF With High-Resolution Phenotyping

机译：高分辨率表型分析HFpEF的病理生理学
- 作者：Nicholas E. Houstis
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- diffusion;
- exercise intolerance;
- HFpEF;
- peripheral oxygen extraction;
80.Reversing Heart Failure With a Ventricular Anchoring Device

机译：用心室锚定装置逆转心衰
- 作者：J. Eduardo Rame
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- left ventricular systolic dysfunction;
- mitral valve;
- secondary mitral regurgitation;
81.Perking Up Strategies to Control Restenosis

机译：制定策略以控制再狭窄
- 作者：Dario F. Riascos-Bernal
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- ER stress;
- neointima;
- PERK;
- restenosis;
- thrombosis;
82.Cardioprotection Autoretroperfusion and Therapeutic Hypothermia

机译：心脏保护自身再灌注和治疗性体温过低
- 作者：Mohamed El Farissi;Nico H.J. Pijls
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- autoperfusion;
- cardioprotection;
- hypothermia;
- primary PCI;
- reperfusion injury;
- ST-segment elevation myocardial infarction;
83.Heart Failure With Preserved Ejection Fraction in Women

机译：女性保留射血分数的心力衰竭
- 作者：Matthias Barton;Matthias R. Meyer
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- contractility;
- diastolic;
- estrogen;
- estrogen receptors;
- fibrosis;
- heart failure;
- HFpEF;
- HFrEF;
- hormone therapy;
- menopause;
- myocardial;
- PDE5;
- phosphodiesterase-5;
- signaling;
- sildenafil;
- systolic;
84.Dynamic Augmentation of Left Ventricle and Mitral Valve Function With an Implantable Soft Robotic Device

机译：植入式软机器人装置动态增强左心室和二尖瓣功能
- 作者：Mossab Y. Saeed;David Van Story;Christopher J. Payne;Isaac Wamala;Borami Shin;Daniel Bautista-Salinas;David Zurakowski;Pedro J. del Nido;Conor J. Walsh;Nikolay V. Vasilyev
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- left ventricular systolic dysfunction;
- mitral valve;
- secondary mitral regurgitation;
- soft robotic;
85.PERK Inhibition Mitigates Restenosis and Thrombosis

机译：抑制PERK可减轻再狭窄和血栓形成
- 作者：Bowen Wang;Mengxue Zhang;Go Urabe;Yitao Huang;Guojun Chen;Debra Wheeler;David J. Dornbos;III;Allyson Huttinger;Shahid M. Nimjee;Shaoqin Gong;Lian-Wang Guo;K. Craig Kent
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- endothelial cells;
- PERK;
- restenosis;
- smooth muscle cells;
- thrombosis;
86.Selective Autoretroperfusion Provides Substantial Cardioprotection in Swine

机译：选择性自体回输可为猪提供充分的心脏保护作用
- 作者：Jenny S. Choy;Zachary C. Berwick;Brandon D. Kalasho;Lijuan Fu;Deepak L. Bhatt;Jose A. Navia;Ghassan S. Kassab
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- acute myocardial infarction;
- cardioprotection;
- focal mild-hypothermia;
- selective autoretroperfusion;
87.Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

机译：雌激素受体-α非核信号传导赋予心脏保护作用对cGMP-PDE5的抑制作用至关重要
- 作者：Nobuaki Fukuma;Eiki Takimoto;Kazutaka Ueda;Pangyen Liu;Miyu Tajima;Yu Otsu;Taro Kariya;Mutsuo Harada;Haruhiro Toko;Kaori Koga;Robert M. Blanton;Jr.;Richard H. Karas;Issei Komuro
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- cyclic GMP;
- estradiol;
- heart failure;
- non-nuclear signaling;
- sGC stimulator;
88.Iron and Heart Failure

机译：铁与心的衰竭
- 作者：Kambiz Ghafourian;Jason S. Shapiro;Lauren Goodman;Hossein Ardehali
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
- heart failure;
- intravenous iron;
- iron chelation;
- iron deficiency;
89.What I Learned From the Impeachment Process

机译：我从弹Process过程中学到了什么
- 作者：Douglas L. Mann
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第3期
90.Stabilizing Peri-Stent Restenosis Using a Novel Therapeutic Carrier

机译：使用新型治疗载体稳定支架周围再狭窄
- 作者：Patrick H. Kee;Melanie R. Moody;Shao-Ling Huang;Hyunggun Kim;Xing Yin;Tao Peng;Susan T. Laing;Melvin E. Klegerman;Mohammad H. Rahbar;Deborah Vela;Curtis Genstler;Kevin J. Haworth;Christy K. Holland;David D. McPherson
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- atherosclerosis;
- in-stent restenosis;
- nitric oxide;
- pioglitazone;
- ultrasound contrast agent;
91.Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

机译：骨髓细胞预接种与非接种生物可吸收经导管肺动脉瓣置换的差异性小叶重塑
- 作者：Emanuela S. Fioretta;Valentina Lintas;Anna Mallone;Sarah E. Motta;Lisa von Boehmer;Petra E. Dijkman;Nikola Cesarovic;Etem Caliskan;Héctor Rodriguez Cetina Biefer;Miriam Lipiski;Mareike Sauer;Matilde Putti;Henk M. Janssen;Serge H. Söntjens;Anthal I.P.M. Smits;Carlijn V.C. Bouten;Maximilian Y. Emmert;Simon P. Hoerstrup
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
92.Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

机译：Celastrol通过抑制NADPH氧化酶2在瓣膜间质细胞中减轻主动脉瓣钙化。
- 作者：Huibing Liu;Libo Wang;Yating Pan;Xuehui Wang;Yuan Ding;Chaoyuan Zhou;Ajay M. Shah;Guoan Zhao;Min Zhang
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- fibrosis;
- Nox2;
- reactive oxygen species;
- stenosis;
- tripterine;
- valve interstitial cells;
93.Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

机译：声动力学疗法通过巨噬细胞凋亡诱导的内皮细胞凋亡抑制了动脉粥样硬化斑块中的新血管形成。
- 作者：Jianting Yao;Weiwei Gao;Yu Wang;Lu Wang;Kamal Diabakte;Jinyang Li;Jiemei Yang;Yongxing Jiang;Yuerong Liu;Shuyuan Guo;Xuezhu Zhao;Zhengyu Cao;Xi Chen;Qiannan Li;Haiyu Zhang;Wei Wang;Zhen Tian;Bicheng Li;Fang Tian;Guodong Wu;Shirin Pourteymour;Xi Huang;Fancheng Tan;Xiaoru Cao;Zhuowen Yang;Kang Li;Yan Zhang;Yong Li;Zhiguo Zhang;Hong Jin;Ye Tian
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- apoptosis-induced apoptosis;
- atherosclerotic plaque;
- endothelial cell;
- macrophage;
- neovascularization;
- sonodynamic therapy;
94.Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

机译：X因子的心脏表达在压力超负荷中介导心脏肥大和纤维化
- 作者：Xinji Guo;Mikhail A. Kolpakov;Bahman Hooshdaran;William Schappell;Tao Wang;Satoru Eguchi;Katherine J. Elliott;Douglas G. Tilley;A. Koneti Rao;Patricia Andrade-Gordon;Matthew Bunce;Chintala Madhu;Steven R. Houser;Abdelkarim Sabri
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- activated coagulation factor X;
- cardiac hypertrophy;
- coagulation;
- fibrosis;
- protease-activated receptors;
- rivaroxaban;
95.In-Stent Restenosis

机译：支架内再狭窄
- 作者：Anna Lena Lahmann;Michael Joner
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- liposomes;
- percutaneous coronary intervention;
- restenosis;
- ultrasound;
96.Subject- and Leaflet-Specific Remodeling of Polymeric Heart Valves for In Situ Tissue Engineering

机译：原位组织工程聚合物心脏瓣膜的主题和瓣叶特定改造。
- 作者：Petra Mela
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- clinical translation;
- endogenous regeneration;
- heart valves;
- in situ tissue engineering;
- scaffold remodeling;
97.Ancient Remedy for a Modern Disease

机译：现代疾病的古老疗法
- 作者：Calvin Yeang;Sotirios Tsimikas
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- antioxidants;
- aortic stenosis;
- aortic valve replacement;
- echocardiography;
- oxidative stress;
- oxidized phospholipids;
98.Sonodynamic Therapy of Atherosclerotic Plaques

机译：动脉粥样硬化斑块的声动力疗法
- 作者：Tilman Ziegler;Christian Kupatt
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- angiogenesis;
- atherosclerosis;
- sonodynamic therapy;
- VEGF-A;
99.Factor Xa Inhibition A New Strategy for Prevention of Adverse Cardiac Remodeling in Early Stages?

机译：因子Xa抑制是一种预防早期不良心脏重塑的新策略吗？
- 作者：Biykem Bozkurt
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- anticoagulation;
- direct oral anticoagulant;
- factor X;
- factor Xa;
- fibrosis;
- heart failure;
- hypertrophy;
- inflammation;
- rivaroxaban;
- ventricular remodeling;
100.Targeting the Mitochondria in Heart Failure

机译：针对心脏衰竭的线粒体
- 作者：Hani N. Sabbah
- 期刊名称：《JACC: Basic to Translational Science》 | 2020年第1期
- cardiolipin;
- heart failure;
- mitochondria;
- myocardial energetics;
- oxidative phosphorylation;