eLife

【机译】：网上生活

ISSN：-
出版周期：
语言：English

起始发布年份：2012
出版者：Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
出版地：England

数据库引入：PubMed: v1, 2012-, PMC

MeSH词表主题词：Biological Science Disciplines*; Medicine

备注：Mode of access: World Wide Web. Description based on first issue; title from展开▼

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1.Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

机译：石墨烯诱导能量转移解决膜动态多蛋白复合物的纳米镜解剖
- 作者：Nadia Füllbrunn;Zehao Li;Lara Jorde;Christian P Richter;Rainer Kurre;Lars Langemeyer;Changyuan Yu;Carola Meyer;Jörg Enderlein;Christian Ungermann;Jacob Piehler;Changjiang You
- 期刊名称：《eLife》 | 2021年第-1期
- S. cerevisiae;
2.Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

机译：由解离和相关州的差异脂质溶剂化能量动力驱动的膜转运蛋白二聚化
- 作者：Rahul Chadda;Nathan Bernhardt;Elizabeth G Kelley;Susana CM Teixeira;Kacie Griffith;Alejandro Gil-Ley;Tuğba N Öztürk;Lauren E Hughes;Ana Forsythe;Venkatramanan Krishnamani;José D Faraldo-Gómez;Janice L Robertson
- 期刊名称：《eLife》 | 2021年第-1期
- E. coli;
3.Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

机译：两种不同抑制剂人TRPC5通道抑制的结构基础
- 作者：Kangcheng Song;Miao Wei;Wenjun Guo;Li Quan;Yunlu Kang;Jing-Xiang Wu;Lei Chen
- 期刊名称：《eLife》 | 2021年第-1期
- Human;
4.Pore mutation N617D in the skeletal muscle DHPR blocks Ca

机译：骨骼肌DHPR阻塞CA中的孔突变N617D
- 作者：Anamika Dayal;Monica L Fernández-Quintero;Klaus R Liedl;Manfred Grabner
- 期刊名称：《eLife》 | 2021年第-1期
- Mouse;
5.Molecular structures of the eukaryotic retinal importer ABCA4

机译：真核视网膜进口剂ABCA4的分子结构
- 作者：Fangyu Liu;James Lee;Jue Chen
- 期刊名称：《eLife》 | 2021年第-1期
- Human;
6.A critical residue in the α

机译：α中的临界残留物
- 作者：Joseph W Nors;Shipra Gupta;Marcel P Goldschen-Ohm
- 期刊名称：《eLife》 | 2021年第-1期
- Xenopus;
7.ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

机译：ATP和大信号代谢物通量通过Caspase-is活化的Pannexin 1通道
- 作者：Adishesh K Narahari;Alex JB Kreutzberger;Pablo S Gaete;Yu-Hsin Chiu;Susan A Leonhardt;Christopher B Medina;Xueyao Jin;Patrycja W Oleniacz;Volker Kiessling;Paula Q Barrett;Kodi S Ravichandran;Mark Yeager;Jorge E Contreras;Lukas K Tamm;Douglas A Bayliss
- 期刊名称：《eLife》 | 2021年第-1期
- None;
8.Disrupting enzyme fluidity

机译：破坏酶流动性
- 作者：Ganesh Srinivasan Anand;*
- 期刊名称：《eLife》 | 2021年第-1期
- None;
9.Archaeal chromatin ‘slinkies’ are inherently dynamic complexes with deflected DNA wrapping pathways

机译：archaeal染色质Slinkies是固有的动态复合物具有偏转的DNA包装途径
- 作者：Samuel Bowerman;Jeff Wereszczynski;Karolin Luger
- 期刊名称：《eLife》 | 2021年第-1期
- None;
10.Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

机译：超极化对ATP门控通道P2X2结构重排的电压钳缺失分析
- 作者：Rizki Tsari Andriani;Yoshihiro Kubo
- 期刊名称：《eLife》 | 2021年第-1期
- Xenopus;
11.The crystal structure of bromide-bound

机译：溴化物的晶体结构
- 作者：Hai Li;Chia-Ying Huang;Elena G Govorunova;Oleg A Sineshchekov;Adrian Yi;Kenneth J Rothschild;Meitian Wang;Lei Zheng;John L Spudich
- 期刊名称：《eLife》 | 2021年第-1期
- Other;
12.Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

机译：在肌肉烟碱受体中的通道门控与离子渗透之间的耦合
- 作者：John R Strikwerda;Steven M Sine
- 期刊名称：《eLife》 | 2021年第-1期
- None;
13.Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca

机译：CAS的Serca-Phospolamban膜复合物的构建依据的结构基础
- 作者：Daniel K Weber;U Venkateswara Reddy;Songlin Wang;Erik K Larsen;Tata Gopinath;Martin B Gustavsson;Razvan L Cornea;David D Thomas;Alfonso De Simone;Gianluigi Veglia
- 期刊名称：《eLife》 | 2021年第-1期
- E. coli;
14.Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

机译：通过TRNA改性和滑动密码子配对的MRNA阅读框架调节的结构见解
- 作者：Eric D Hoffer;Samuel Hong;S Sunita;Tatsuya Maehigashi;Ruben L Gonzalez Jnr;Paul C Whitford;Christine M Dunham
- 期刊名称：《eLife》 | 2020年第-1期
15.Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

机译：线粒体丙酮酸载体是最佳的棕色脂肪热量所必需的
- 作者：Vanja Panic;Stephanie Pearson;James Banks;Trevor S Tippetts;Jesse N Velasco-Silva;Sanghoon Lee;Judith Simcox;Gisela Geoghegan;Claire L Bensard;Tyler van Ry;Will L Holland;Scott A Summers;James Cox;Gregory S Ducker;Jared Rutter;Claudio J Villanueva
- 期刊名称：《eLife》 | 2020年第-1期
16.Talin-activated vinculin interacts with branched actin networks to initiate bundles

机译：瞳孔激活的vinculin与分支的actin网络相互作用以启动捆绑包
- 作者：Rajaa Boujemaa-Paterski;Bruno Martins;Matthias Eibauer;Charlie T Beales;Benjamin Geiger;Ohad Medalia
- 期刊名称：《eLife》 | 2020年第-1期
17.Underground isoleucine biosynthesis pathways in E. coli

机译：大肠杆菌的地下异氨酸生物合成途径
- 作者：Charles AR Cotton;Iria Bernhardsgrütter;Hai He;Simon Burgener;Luca Schulz;Nicole Paczia;Beau Dronsella;Alexander Erban;Stepan Toman;Marian Dempfle;Alberto De Maria;Joachim Kopka;Steffen N Lindner;Tobias J Erb;Arren Bar-Even
- 期刊名称：《eLife》 | 2020年第-1期
18.A physicochemical perspective of aging from single-cell analysis of pH macromolecular and organellar crowding in yeast

机译：酵母中单细胞分析衰老的理化视角
- 作者：Sara N Mouton;David J Thaller;Matthew M Crane;Irina L Rempel;Owen T Terpstra;Anton Steen;Matt Kaeberlein;C Patrick Lusk;Arnold J Boersma;Liesbeth M Veenhoff
- 期刊名称：《eLife》 | 2020年第-1期
19.Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

机译：高突变扫描的G蛋白偶联受体的结构和功能表征
- 作者：Eric M Jones;Nathan B Lubock;AJ Venkatakrishnan;Jeffrey Wang;Alex M Tseng;Joseph M Paggi;Naomi R Latorraca;Daniel Cancilla;Megan Satyadi;Jessica E Davis;M Madan Babu;Ron O Dror;Sriram Kosuri
- 期刊名称：《eLife》 | 2020年第-1期
20.Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

机译：SKD3（人CLPB）是一种有效的线粒体蛋白质解淀粉其灭活了3-甲基戊烯酸核尿蛋白联系突变
- 作者：Ryan R Cupo;James Shorter
- 期刊名称：《eLife》 | 2020年第-1期
21.A novel DNA primase-helicase pair encoded by SCCmec elements

机译：由SCCMEC元素编码的新型DNA预级螺旋酶对
- 作者：Aleksandra Bebel;Melissa A Walsh;Ignacio Mir-Sanchis;Phoebe A Rice
- 期刊名称：《eLife》 | 2020年第-1期
22.Serine phosphorylation regulates the P-type potassium pump KdpFABC

机译：丝氨酸磷酸化调节P型钾泵KDPFABC
- 作者：Marie E Sweet;Xihui Zhang;Hediye Erdjument-Bromage;Vikas Dubey;Himanshu Khandelia;Thomas A Neubert;Bjørn P Pedersen;David L Stokes
- 期刊名称：《eLife》 | 2020年第-1期
23.Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice

机译：SIRT1和SIRT6之间的协同作用有助于识别DNA破裂并提高DNA损伤反应和在人和小鼠中的修复
- 作者：Fanbiao Meng;Minxian Qian;Bin Peng;Linyuan Peng;Xiaohui Wang;Kang Zheng;Zuojun Liu;Xiaolong Tang;Shuju Zhang;Shimin Sun;Xinyue Cao;Qiuxiang Pang;Bosheng Zhao;Wenbin Ma;Zhou Songyang;Bo Xu;Wei-Guo Zhu;Xingzhi Xu;Baohua Liu
- 期刊名称：《eLife》 | 2020年第-1期
24.Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

机译：Nucleosome-CHD4染色质Remodeler结构地图人类疾病突变
- 作者：Lucas Farnung;Moritz Ochmann;Patrick Cramer
- 期刊名称：《eLife》 | 2020年第-1期
25.Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

机译：Moyamoya疾病因子RNF213是一种巨大的E3连接酶其具有Dynein样芯和不同的泛素转移机制
- 作者：Juraj Ahel;Anita Lehner;Antonia Vogel;Alexander Schleiffer;Anton Meinhart;David Haselbach;Tim Clausen
- 期刊名称：《eLife》 | 2020年第-1期
26.Chemical and structural investigation of the paroxetine-human serotonin transporter complex

机译：帕罗西汀 - 人血清素转运蛋白复合物的化学和结构研究
- 作者：Jonathan A Coleman;Vikas Navratna;Daniele Antermite;Dongxue Yang;James A Bull;Eric Gouaux
- 期刊名称：《eLife》 | 2020年第-1期
27.A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

机译：单分子分辨率下人体端粒酶延伸和展开平行端粒型G-四配合的机制
- 作者：Bishnu P Paudel;Aaron Lavel Moye;Hala Abou Assi;Roberto El-Khoury;Scott B Cohen;Jessica K Holien;Monica L Birrento;Siritron Samosorn;Kamthorn Intharapichai;Christopher G Tomlinson;Marie-Paule Teulade-Fichou;Carlos González;Jennifer L Beck;Masad J Damha;Antoine M van Oijen;Tracy M Bryan
- 期刊名称：《eLife》 | 2020年第-1期
28.Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

机译：测量腹股沟蛋白笼中的蛋白质稳定性显示出大量的稳定化
- 作者：Ilia Korobko;Hisham Mazal;Gilad Haran;Amnon Horovitz
- 期刊名称：《eLife》 | 2020年第-1期
29.Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

机译：含铁钢和谷胱甘肽的变化促进了胶叶炎秀丽隐杆线虫衰老和脆弱
- 作者：Nicole L Jenkins;Simon A James;Agus Salim;Fransisca Sumardy;Terence P Speed;Marcus Conrad;Des R Richardson;Ashley I Bush;Gawain McColl
- 期刊名称：《eLife》 | 2020年第-1期
30.Atomic structure of a mitochondrial complex I intermediate from vascular plants

机译：来自血管植物中中间体的线粒体复合物的原子结构
- 作者：Maria Maldonado;Abhilash Padavannil;Long Zhou;Fei Guo;James A Letts
- 期刊名称：《eLife》 | 2020年第-1期
31.Controlling protein function by fine-tuning conformational flexibility

机译：通过微调构象灵活性来控制蛋白质功能
- 作者：Sonja Schmid;Thorsten Hugel
- 期刊名称：《eLife》 | 2020年第-1期
32.A two-lane mechanism for selective biological ammonium transport

机译：一种用于选择性生物铵运输的双线机制
- 作者：Gordon Williamson;Giulia Tamburrino;Adriana Bizior;Mélanie Boeckstaens;Gaëtan Dias Mirandela;Marcus G Bage;Andrei Pisliakov;Callum M Ives;Eilidh Terras;Paul A Hoskisson;Anna Maria Marini;Ulrich Zachariae;Arnaud Javelle
- 期刊名称：《eLife》 | 2020年第-1期
33.How to measure and evaluate binding affinities

机译：如何测量和评估结合亲和力
- 作者：Inga Jarmoskaite;Ishraq AlSadhan;Pavanapuresan P Vaidyanathan;Daniel Herschlag
- 期刊名称：《eLife》 | 2020年第-1期
34.Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

机译：CRISPR环核酸酶CRN3 / CSX3的四分离化促进了循环寡核苷酸切割
- 作者：Januka S Athukoralage;Stuart McQuarrie;Sabine Grüschow;Shirley Graham;Tracey M Gloster;Malcolm F White
- 期刊名称：《eLife》 | 2020年第-1期
35.Diverse nucleosome Site-Selectivity among histone deacetylase complexes

机译：组蛋白脱乙酰酶复合物中不同的核小体遗址 - 选择性
- 作者：Zhipeng A Wang;Christopher J Millard;Chia-Liang Lin;Jennifer E Gurnett;Mingxuan Wu;Kwangwoon Lee;Louise Fairall;John WR Schwabe;Philip A Cole
- 期刊名称：《eLife》 | 2020年第-1期
36.Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

机译：通过激酶的调节区段破裂寡聚型Camkii枢刺
- 作者：Deepti Karandur;Moitrayee Bhattacharyya;Zijie Xia;Young Kwang Lee;Serena Muratcioglu;Darren McAffee;Ethan D McSpadden;Baiyu Qiu;Jay T Groves;Evan R Williams;John Kuriyan
- 期刊名称：《eLife》 | 2020年第-1期
37.Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

机译：细菌激素治疗抗疟疾生物合成的生化基础
- 作者：Iti Kapoor;Philip Olivares;Satish K Nair
- 期刊名称：《eLife》 | 2020年第-1期
38.High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

机译：多个5-HT3AR-SetROR复合物的高分辨率结构揭示了一种竞争性抑制的新机制
- 作者：Sandip Basak;Arvind Kumar;Steven Ramsey;Eric Gibbs;Abhijeet Kapoor;Marta Filizola;Sudha Chakrapani
- 期刊名称：《eLife》 | 2020年第-1期
39.The architecture of EMC reveals a path for membrane protein insertion

机译：EMC的结构揭示了膜蛋白插入的路径
- 作者：John P ODonnell;Ben P Phillips;Yuichi Yagita;Szymon Juszkiewicz;Armin Wagner;Duccio Malinverni;Robert J Keenan;Elizabeth A Miller;Ramanujan S Hegde
- 期刊名称：《eLife》 | 2020年第-1期
40.Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

机译：线粒体脂肪酸合成坐标哺乳动物线粒体氧化代谢
- 作者：Sara M Nowinski;Ashley Solmonson;Scott F Rusin;J Alan Maschek;Claire L Bensard;Sarah Fogarty;Mi-Young Jeong;Sandra Lettlova;Jordan A Berg;Jeffrey T Morgan;Yeyun Ouyang;Bradley C Naylor;Joao A Paulo;Katsuhiko Funai;James E Cox;Steven P Gygi;Dennis R Winge;Ralph J DeBerardinis;Jared Rutter
- 期刊名称：《eLife》 | 2020年第-1期
41.Structural insight into toxin secretion by contact-dependent growth inhibition transporters

机译：通过接触依赖性生长抑制转运蛋白对毒素分泌的结构洞察
- 作者：Jeremy Guerin;Istvan Botos;Zijian Zhang;Karl Lundquist;James C Gumbart;Susan K Buchanan
- 期刊名称：《eLife》 | 2020年第-1期
42.Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes

机译：染色质Remodeler RSC的专业化可以动员部分未包装的核心
- 作者：Alisha Schlichter;Margaret M Kasten;Timothy J Parnell;Bradley R Cairns
- 期刊名称：《eLife》 | 2020年第-1期
43.Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

机译：细菌OTU脱硫酶调节军团菌感染的底物泛素
- 作者：Donghyuk Shin;Anshu Bhattacharya;Yi-Lin Cheng;Marta Campos Alonso;Ahmad Reza Mehdipour;Gerbrand J van der Heden van Noort;Huib Ovaa;Gerhard Hummer;Ivan Dikic
- 期刊名称：《eLife》 | 2020年第-1期
44.Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

机译：MCM2和RAD53对抗DDK绑定到许可复制的拮抗控制
- 作者：Syafiq Abd Wahab;Dirk Remus
- 期刊名称：《eLife》 | 2020年第-1期
45.The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

机译：通过节段标记显示的AKT的pH结构型调节的结构决定因子
- 作者：Nam Chu;Thibault Viennet;Hwan Bae;Antonieta Salguero;Andras Boeszoermenyi;Haribabu Arthanari;Philip A Cole
- 期刊名称：《eLife》 | 2020年第-1期
46.Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

机译：单分子聚（a）尾SEQ显示LARP4在MRNA寿命中反对过硬化大部分对短尾部的影响
- 作者：Sandy Mattijssen;James R Iben;Tianwei Li;Steven L Coon;Richard J Maraia
- 期刊名称：《eLife》 | 2020年第-1期
47.Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

机译：在Cohesin中的DNA运输涉及通过SCC2夹紧在有关的头部顶部并通过SCC3夹紧环内
- 作者：James E Collier;Byung-Gil Lee;Maurici Brunet Roig;Stanislav Yatskevich;Naomi J Petela;Jean Metson;Menelaos Voulgaris;Andres Gonzalez Llamazares;Jan Löwe;Kim A Nasmyth
- 期刊名称：《eLife》 | 2020年第-1期
48.Mechanistic insights into volatile anesthetic modulation of K2P channels

机译：机械洞察K2P频道的挥发性调制
- 作者：Aboubacar Wague;Thomas T Joseph;Kellie A Woll;Weiming Bu;Kiran A Vaidya;Natarajan V Bhanu;Benjamin A Garcia;Crina M Nimigean;Roderic G Eckenhoff;Paul M Riegelhaupt
- 期刊名称：《eLife》 | 2020年第-1期
49.Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

机译：结构揭示了Micu1-Micu2的线粒体Ca2 +单百+的尿道
- 作者：Chongyuan Wang;Agata Jacewicz;Bryce D Delgado;Rozbeh Baradaran;Stephen Barstow Long
- 期刊名称：《eLife》 | 2020年第-1期
50.Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

机译：发现分子胶水促进CDK12-DDB1相互作用以触发细胞周期蛋白k降解
- 作者：Lu Lv;Peihao Chen;Longzhi Cao;Yamei Li;Zhi Zeng;Yue Cui;Qingcui Wu;Jiaojiao Li;Jian-Hua Wang;Meng-Qiu Dong;Xiangbing Qi;Ting Han
- 期刊名称：《eLife》 | 2020年第-1期
51.Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

机译：结构见解进入人体线粒体钙二百月的CA2 +依赖性网
- 作者：Yan Wang;Yan Han;Ji She;Nam X Nguyen;Vamsi K Mootha;Xiao-chen Bai;Youxing Jiang
- 期刊名称：《eLife》 | 2020年第-1期
52.Task specialization across research careers

机译：跨研究职业的任务专业化
- 作者：Nicolas Robinson-Garcia;*;Rodrigo Costas;*;Cassidy R Sugimoto;*;Vincent Larivière;*;Gabriela F Nane;*
- 期刊名称：《eLife》 | 2020年第-1期
53.Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

机译：SEC和BAM转译的膜膜结合用于细菌外膜生物
- 作者：Sara Alvira;Daniel W Watkins;Lucy Troman;William J Allen;James S Lorriman;Gianluca Degliesposti;Eli J Cohen;Morgan Beeby;Bertram Daum;Vicki AM Gold;J Mark Skehel;Ian Collinson
- 期刊名称：《eLife》 | 2020年第-1期
54.Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

机译：在核糖体上的分氯化物折叠过程中逐渐压实新生肽
- 作者：Marija Liutkute;Manisankar Maiti;Ekaterina Samatova;Jörg Enderlein;Marina V Rodnina
- 期刊名称：《eLife》 | 2020年第-1期
55.Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

机译：用组合完整的图书馆揭示蛋白质 - 蛋白质相互作用特异性的基础
- 作者：Thuy-Lan V Lite;Robert A Grant;Isabel Nocedal;Megan L Littlehale;Monica S Guo;Michael T Laub
- 期刊名称：《eLife》 | 2020年第-1期
56.A molecular dual carriageway

机译：分子双车道
- 作者：William J Allen;*;Ian Collinson;*
- 期刊名称：《eLife》 | 2020年第-1期
57.POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan

机译：Pomk通过大1介导的矩形伸长率来调节Dystoglycan功能
- 作者：Ameya S Walimbe;Hidehiko Okuma;Soumya Joseph;Tiandi Yang;Takahiro Yonekawa;Jeffrey M Hord;David Venzke;Mary E Anderson;Silvia Torelli;Adnan Manzur;Megan Devereaux;Marco Cuellar;Sally Prouty;Saul Ocampo Landa;Liping Yu;Junyu Xiao;Jack E Dixon;Francesco Muntoni;Kevin P Campbell
- 期刊名称：《eLife》 | 2020年第-1期
58.ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

机译：CLPAP蛋白水解不需要CLPA相对于CLPP的旋转序列
- 作者：Sora Kim;Kristin L Zuromski;Tristan A Bell;Robert T Sauer;Tania A Baker
- 期刊名称：《eLife》 | 2020年第-1期
59.Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

机译：PHACTR1 / PP1磷酸酶全酶底物特异性的分子基础
- 作者：Roman O Fedoryshchak;Magdalena Přechová;Abbey M Butler;Rebecca Lee;Nicola OReilly;Helen R Flynn;Ambrosius P Snijders;Noreen Eder;Sila Ultanir;Stephane Mouilleron;Richard Treisman
- 期刊名称：《eLife》 | 2020年第-1期
60.Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

机译：Caenorhabditis elefans的模块化代谢物组件取决于羧基酯酶和粘结体相关的细胞器的形成
- 作者：Henry H Le;Chester JJ Wrobel;Sarah M Cohen;Jingfang Yu;Heenam Park;Maximilian J Helf;Brian J Curtis;Joseph C Kruempel;Pedro Reis Rodrigues;Patrick J Hu;Paul W Sternberg;Frank C Schroeder
- 期刊名称：《eLife》 | 2020年第-1期
61.Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

机译：mRNA的烷基化损伤导致核糖体停滞和通过细菌的跨转换拯救
- 作者：Erica N Thomas;Kyusik Q Kim;Emily P McHugh;Thomas Marcinkiewicz;Hani S Zaher
- 期刊名称：《eLife》 | 2020年第-1期
62.Transport mechanism of P4 ATPase phosphatidylcholine flippases

机译：P4 ATP酶磷脂酰胆碱烫伤的转运机理
- 作者：Lin Bai;Qinglong You;Bhawik K Jain;H Diessel Duan;Amanda Kovach;Todd R Graham;Huilin Li
- 期刊名称：《eLife》 | 2020年第-1期
63.Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

机译：vemp的精细互动分析以及负责其易位耦合逮捕取消的机制
- 作者：Ryoji Miyazaki;Yoshinori Akiyama;Hiroyuki Mori
- 期刊名称：《eLife》 | 2020年第-1期
64.Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

机译：抗微生物肽αecin对细菌翻译终止的基因组
- 作者：Kyle Mangano;Tanja Florin;Xinhao Shao;Dorota Klepacki;Irina Chelysheva;Zoya Ignatova;Yu Gao;Alexander S Mankin;Nora Vázquez-Laslop
- 期刊名称：《eLife》 | 2020年第-1期
65.Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

机译：钙释放活化钙通道奥海的Cryo-EM结构在开放构象中
- 作者：Xiaowei Hou;Ian R Outhwaite;Leanne Pedi;Stephen Barstow Long
- 期刊名称：《eLife》 | 2020年第-1期
66.In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters

机译：体外重构动态相互作用的能量耦合因子输送器的整体膜亚基
- 作者：Inda Setyawati;Weronika K Stanek;Maria Majsnerowska;Lotteke J Y M Swier;Els Pardon;Jan Steyaert;Albert Guskov;Dirk J Slotboom
- 期刊名称：《eLife》 | 2020年第-1期
67.A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

机译：基材结合的Synaptojanin1的结构在其机制和疾病突变的影响下提供了新的见解
- 作者：Jone Paesmans;Ella Martin;Babette Deckers;Marjolijn Berghmans;Ritika Sethi;Yannick Loeys;Els Pardon;Jan Steyaert;Patrik Verstreken;Christian Galicia;Wim Versées
- 期刊名称：《eLife》 | 2020年第-1期
68.Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

机译：使用高尺寸外周血流量细胞计量自然杀伤细胞亚集表型表型数据表型数据型数据型数据型数据型数据型数据鉴定数据
- 作者：Simon P Hood;Georgina Cosma;Gemma A Foulds;Catherine Johnson;Stephen Reeder;Stéphanie E McArdle;Masood A Khan;A Graham Pockley
- 期刊名称：《eLife》 | 2020年第-1期
69.AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival

机译：Ar磷酸化和CHK2激酶活性调节IR稳定的AR-CHK2相互作用和前列腺癌生存
- 作者：Huy Q Ta;Natalia Dworak;Melissa L Ivey;Devin G Roller;Daniel Gioeli
- 期刊名称：《eLife》 | 2020年第-1期
70.Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

机译：将免疫抑制肿瘤微环境解剖到胶质母细胞瘤芯片中的优化PD-1免疫疗法
- 作者：Xin Cui;Chao Ma;Varshini Vasudevaraja;Jonathan Serrano;Jie Tong;Yansong Peng;Michael Delorenzo;Guomiao Shen;Joshua Frenster;Renee-Tyler Tan Morales;Weiyi Qian;Aristotelis Tsirigos;Andrew S Chi;Rajan Jain;Sylvia C Kurz;Erik P Sulman;Dimitris G Placantonakis;Matija Snuderl;Weiqiang Chen
- 期刊名称：《eLife》 | 2020年第-1期
71.Dissecting transcriptional amplification by MYC

机译：解剖通过Myc的转录扩增
- 作者：Zuqin Nie;Chunhua Guo;Subhendu K Das;Carson C Chow;Eric Batchelor;S Stoney Simons Jnr;David Levens
- 期刊名称：《eLife》 | 2020年第-1期
72.MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

机译：梅斯介导的抑制人类前列腺癌生长和转移通过丙二酮蛋白酶多糖的调控
- 作者：Calvin VanOpstall;Srikanth Perike;Hannah Brechka;Marc Gillard;Sophia Lamperis;Baizhen Zhu;Ryan Brown;Raj Bhanvadia;Donald J Vander Griend
- 期刊名称：《eLife》 | 2020年第-1期
73.Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

机译：结合缺失Glut1和Glut3损害肺腺癌生长
- 作者：Caroline Contat;Pierre-Benoit Ancey;Nadine Zangger;Silvia Sabatino;Justine Pascual;Stéphane Escrig;Louise Jensen;Christine Goepfert;Bernard Lanz;Mario Lepore;Rolf Gruetter;Anouk Rossier;Sabina Berezowska;Christina Neppl;Inti Zlobec;Stéphanie Clerc-Rosset;Graham William Knott;Jeffrey C Rathmell;E Dale Abel;Anders Meibom;Etienne Meylan
- 期刊名称：《eLife》 | 2020年第-1期
74.A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

机译：由推定的LNCRNA编码的小蛋白质调节人结肠直肠癌细胞中的凋亡和致瘤性
- 作者：Xiao Ling Li;Lőrinc Pongor;Wei Tang;Sudipto Das;Bruna R Muys;Matthew F Jones;Sarah B Lazar;Emily A Dangelmaier;Corrine CR Hartford;Ioannis Grammatikakis;Qinyu Hao;Qinyu Sun;Aaron Schetter;Jennifer L Martindale;BinWu Tang;Lisa M Jenkins;Ana I Robles;Robert L Walker;Stefan Ambs;Raj Chari;Svetlana A Shabalina;Myriam Gorospe;S Perwez Hussain;Curtis C Harris;Paul S Meltzer;Kannanganattu V Prasanth;Mirit I Aladjem;Thorkell Andresson;Ashish Lal
- 期刊名称：《eLife》 | 2020年第-1期
75.Cancer systems immunology

机译：癌症系统免疫学
- 作者：Nathan E Reticker-Flynn;Edgar G Engleman
- 期刊名称：《eLife》 | 2020年第-1期
76.Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

机译：人的抗病是一种雄激抑制的存活因子调节PUFA氧化以保护前列腺肿瘤细胞免受脱裂病变
- 作者：Zeyad D Nassar;Chui Yan Mah;Jonas Dehairs;Ingrid JG Burvenich;Swati Irani;Margaret M Centenera;Madison Helm;Raj K Shrestha;Max Moldovan;Anthony S Don;Jeff Holst;Andrew M Scott;Lisa G Horvath;David J Lynn;Luke A Selth;Andrew J Hoy;Johannes V Swinnen;Lisa M Butler
- 期刊名称：《eLife》 | 2020年第-1期
77.Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

机译：Ostrox-Cre标志着具有促致骨骼肿瘤的CD45和CD45 +基质群体的不同子集具有促致瘤瘤的特征
- 作者：Biancamaria Ricci;Eric Tycksen;Hamza Celik;Jad I Belle;Francesca Fontana;Roberto Civitelli;Roberta Faccio
- 期刊名称：《eLife》 | 2020年第-1期
78.MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

机译：3月5日介导通过激酶抑制剂驱动的NOXA依赖性MCL1降解和综合应力反应激活
- 作者：Seiji Arai;Andreas Varkaris;Mannan Nouri;Sen Chen;Lisha Xie;Steven P Balk
- 期刊名称：《eLife》 | 2020年第-1期
79.NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

机译：Nurd Subunit CHD4调节横纹肌肉瘤中的超增强剂可访问性代表了一般的肿瘤依赖
- 作者：Joana G Marques;Berkley E Gryder;Blaz Pavlovic;Yeonjoo Chung;Quy A Ngo;Fabian Frommelt;Matthias Gstaiger;Young Song;Katharina Benischke;Dominik Laubscher;Marco Wachtel;Javed Khan;Beat W Schäfer
- 期刊名称：《eLife》 | 2020年第-1期
80.A perspective on HPK1 as a novel immuno-oncology drug target

机译：HPK1作为一种新型免疫肿瘤药物目标的透视
- 作者：Sansana Sawasdikosol;Steven Burakoff
- 期刊名称：《eLife》 | 2020年第-1期
81.Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

机译：鉴定靶向线粒体呼吸络合物的抗癌化学治疗剂的新型毒性细胞
- 作者：Zoe A Stephenson;Robert F Harvey;Kenneth R Pryde;Sarah Mistry;Rachel E Hardy;Riccardo Serreli;Injae Chung;Timothy EH Allen;Mark Stoneley;Marion MacFarlane;Peter M Fischer;Judy Hirst;Barrie Kellam;Anne E Willis
- 期刊名称：《eLife》 | 2020年第-1期
82.Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

机译：抑制IRE1α-内切核酸酶活性降低肝细胞癌小鼠模型中的肿瘤负担
- 作者：Nataša Pavlović;Carlemi Calitz;Kess Thanapirom;Guiseppe Mazza;Krista Rombouts;Pär Gerwins;Femke Heindryckx
- 期刊名称：《eLife》 | 2020年第-1期
83.Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

机译：含有非洲中心肿瘤预测P53 Variant Pro47ser的小鼠和人体细胞中的MTOR活性和代谢效率增加
- 作者：Keerthana Gnanapradeepan;Julia I-Ju Leu;Subhasree Basu;Thibaut Barnoud;Madeline Good;Joyce V Lee;William J Quinn;Che-Pei Kung;Rexford Ahima;Joseph A Baur;Kathryn E Wellen;Qin Liu;Zachary T Schug;Donna L George;Maureen E Murphy
- 期刊名称：《eLife》 | 2020年第-1期
84.The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

机译：Zebrafish模型鉴定双保护剂对顺铂诱导的耳蛋白和肾毒性的鉴定
- 作者：Jaime N Wertman;Nicole Melong;Matthew R Stoyek;Olivia Piccolo;Stewart Langley;Benno Orr;Shelby L Steele;Babak Razaghi;Jason N Berman
- 期刊名称：《eLife》 | 2020年第-1期
85.Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

机译：复制研究：通过竞争内源MRNA对肿瘤抑制器PTEN的编码抑制性调节
- 作者：Hongyan Wang;Hanna S Radomska;Mitch A Phelps;Elizabeth Iorns;Rachel Tsui;Alexandria Denis;Nicole Perfito;Timothy M Errington
- 期刊名称：《eLife》 | 2020年第-1期
86.A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

机译：靶向谷氨酰胺成瘾治疗人肝癌的强大药物组合策略
- 作者：Haojie Jin;Siying Wang;Esther A Zaal;Cun Wang;Haiqiu Wu;Astrid Bosma;Fleur Jochems;Nikita Isima;Guangzhi Jin;Cor Lieftink;Roderick Beijersbergen;Celia R Berkers;Wenxin Qin;Rene Bernards
- 期刊名称：《eLife》 | 2020年第-1期
87.Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

机译：在胰腺导管腺癌中解剖细胞类型特异性代谢
- 作者：Allison N Lau;Zhaoqi Li;Laura V Danai;Anna M Westermark;Alicia M Darnell;Raphael Ferreira;Vasilena Gocheva;Sharanya Sivanand;Evan C Lien;Kiera M Sapp;Jared R Mayers;Giulia Biffi;Christopher R Chin;Shawn M Davidson;David A Tuveson;Tyler Jacks;Nicholas J Matheson;Omer Yilmaz;Matthew G Vander Heiden
- 期刊名称：《eLife》 | 2020年第-1期
88.Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

机译：乳腺癌细胞的三维生长增强了未联系的Ghrelin和AZP-531的抗肿瘤作用
- 作者：CheukMan C Au;John B Furness;Kara Britt;Sofya Oshchepkova;Heta Ladumor;Kai Ying Soo;Brid Callaghan;Celine Gerard;Giorgio Inghirami;Vivek Mittal;Yufeng Wang;Xin Yun Huang;Jason A Spector;Eleni Andreopoulou;Paul Zumbo;Doron Betel;Lukas Dow;Kristy A Brown
- 期刊名称：《eLife》 | 2020年第-1期
89.Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

机译：KLF5的重新促使在前体态到食管腺癌的进展期间激活细胞周期签名
- 作者：Connor Rogerson;Samuel Ogden;Edward Britton;Yeng Ang;Andrew D Sharrocks
- 期刊名称：《eLife》 | 2020年第-1期
90.Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

机译：癌症相关的成纤维细胞及其对肿瘤免疫和免疫疗法的影响
- 作者：Richard Lee Barrett;Ellen Puré
- 期刊名称：《eLife》 | 2020年第-1期
91.The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

机译：Testis蛋白ZNF165是SMAD3辅因子其坐标其在三阴性乳腺癌中致癌致型TGFβ信号传导
- 作者：Zane A Gibbs;Luis C Reza;Chun-Chun Cheng;Jill M Westcott;Kathleen McGlynn;Angelique W Whitehurst
- 期刊名称：《eLife》 | 2020年第-1期
92.Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

机译：通过基于Report-C的CRISPR / CAS9屏幕MLLR白血病Hoxa9牙髓功能询问
- 作者：Hao Zhang;Yang Zhang;Xinyue Zhou;Shaela Wright;Judith Hyle;Lianzhong Zhao;Jie An;Xujie Zhao;Ying Shao;Beisi Xu;Hyeong-Min Lee;Taosheng Chen;Yang Zhou;Xiang Chen;Rui Lu;Chunliang Li
- 期刊名称：《eLife》 | 2020年第-1期
93.PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

机译：PTEN和DNA-PK响应于人乳腺癌中的WEE1抑制来确定敏感性和恢复
- 作者：Andrä Brunner;Aldwin Suryo Rahmanto;Henrik Johansson;Marcela Franco;Johanna Viiliäinen;Mohiuddin Gazi;Oliver Frings;Erik Fredlund;Charles Spruck;Janne Lehtiö;Juha K Rantala;Lars-Gunnar Larsson;Olle Sangfelt
- 期刊名称：《eLife》 | 2020年第-1期
94.Sperm-specific COX6B2 enhances oxidative phosphorylation proliferation and survival in human lung adenocarcinoma

机译：精子特异性COX6B2增强人肺腺癌中的氧化磷酸化增殖和生存期
- 作者：Chun-Chun Cheng;Joshua Wooten;Zane A Gibbs;Kathleen McGlynn;Prashant Mishra;Angelique W Whitehurst
- 期刊名称：《eLife》 | 2020年第-1期
95.Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

机译：通过NSCLC球体中的EGFR信号传导的垂直抑制标记的协同作用显示SOS1是EGFR-突变癌症的治疗靶标
- 作者：Patricia L Theard;Erin Sheffels;Nancy E Sealover;Amanda J Linke;David J Pratico;Robert L Kortum
- 期刊名称：《eLife》 | 2020年第-1期
96.Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

机译：大规模函数屏幕的综合分析识别强大的癌症相关遗传相互作用
- 作者：Christopher J Lord;Niall Quinn;Colm J Ryan
- 期刊名称：《eLife》 | 2020年第-1期
97.Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

机译：在卵巢小细胞癌中的Smarca4 / BRG1的重新表达高钙型（SCCOHT）通过AP-1依赖性机制促进上皮样基因签名
- 作者：Krystal Ann Orlando;Amber K Douglas;Aierken Abudu;Yemin Wang;Basile Tessier-Cloutier;Weiping Su;Alec Peters;Larry S Sherman;Rayvon Moore;Vinh Nguyen;Gian Luca Negri;Shane Colborne;Gregg B Morin;Friedrich Kommoss;Jessica D Lang;William PD Hendricks;Elizabeth A Raupach;Patrick Pirrotte;David G Huntsman;Jeffrey M Trent;Joel S Parker;Jesse R Raab;Bernard E Weissman
- 期刊名称：《eLife》 | 2020年第-1期
98.The mitochondrial paradox

机译：线粒体悖论
- 作者：Sophie L Penman;*;Rebecca L Jensen;*;Robyn T Kiy;*;Amy E Chadwick;*
- 期刊名称：《eLife》 | 2020年第-1期
99.A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

机译：小鼠和人类前列腺的单细胞阿特拉斯揭示了上皮祖细胞的异质性和保护
- 作者：Laura Crowley;Francesco Cambuli;Luis Aparicio;Maho Shibata;Brian D Robinson;Shouhong Xuan;Weiping Li;Hanina Hibshoosh;Massimo Loda;Raul Rabadan;Michael M Shen
- 期刊名称：《eLife》 | 2020年第-1期
100.Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

机译：细胞毒性T细胞介导运动诱导的肿瘤生长减少
- 作者：Helene Rundqvist;Pedro Veliça;Laura Barbieri;Paulo A Gameiro;David Bargiela;Milos Gojkovic;Sara Mijwel;Stefan Markus Reitzner;David Wulliman;Emil Ahlstedt;Jernej Ule;Arne Östman;Randall S Johnson
- 期刊名称：《eLife》 | 2020年第-1期