Structure-activity relationships of natural and synthetic neo-clerodane diterpenes from Teucrium against colorado potato beetle larvae

摘要

Treatment of potato leaf disks with ten neo-clerodane diterpenes isolated from Teucrium and with ten of their synthetic derivatives, resulted in a significant antifeedant activity against Leptinotarsa decemlineata larvae in both choice and no-choice assays for nine of the natural products and three of the hemisynthetic compounds. Changes in the antifeedant activity were associated with certain structural features of the compounds and some significant aspects of the structure-activity relationship are discussed.