Chemical composition, antibacterial, antioxidant and tyrosinase inhibitory activities of glycosides from aerial parts of Eryngium tricuspidatum L.

摘要

Two new phenolic glucosides, together with six known compounds, were isolated from the aerial part of Eryngium tricuspidatum L. (Apiaceae). The structures of the new compounds were established as 2-hydroxy- 3,5-dimethyl-acetophenon-4-O-beta-D-glucopyranoside (1) and 2,3-dimethyl-4-hydroxymethylphenyl- 1-hydroxymethyl-O-beta-D-glucopyranoside (2) on the basis of detailed spectroscopic data including MS, 1D, and 2D NMR. The antibacterial, tyrosinase inhibitory and DPPH radical scavenging activities of hydromethanolic extract, fractions, and the eight isolated compounds were evaluated. The antibacterial assay showed a moderate activity for magnolioside (4) against Staphylococcus aureus CIP 53.154. Compound 7 (quercetin 3-O-beta-D-glucopyranosyl-(1 -> 6)-O-beta-D-galactopyranoside) had moderate DPPH radical scavenging activity whereas compounds 2 exhibited good inhibitory effect against mushroom tyrosinase. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.