High-Molecular-Weight HPMA-Based Polymer Drug Carriers for Delivery to Tumor

摘要

In this work, design and synthesis of high-molecular-weight N-(2-hydroxypropyl) methacrylamide-based polymer drug delivery systems tailored for cancer therapy is summarized. Moreover, the influence of their architecture on tumor accumulation and in vivo anti-cancer efficacy is discussed. Mainly, the high-molecular-weight delivery systems, such as branched, grafted, multi-block, star-like or micellar systems, with molecular weights greater than the renal threshold are discussed and reviewed in detail.