Brewinga drug delivery platform

摘要

A pH responsive film that releases drugs to kill cancer cells could find applications from implant coatings to drug delivery systems, say scientists in the US and Korea.Paula Hammond from Massachusetts Institute of Technology, Cambridge, and colleagues created the film by trapping polymeric spheres in a multilayered surface. To make the spheres they attached a hydrophobic chemotherapeutic agent -doxorubicin - to abiocompatible polymer using a labile, pH-responsive linker. On adding a buffer, the drug-loaded polymer forms a suspension of spherical hydrophobic micelles in the aqueous liquid. The researchers then integrated the micelles into thin films using a layer-by-layer (LbL) deposition technique.