Pleiotropic effects of negative energy balance in the postpartum dairy cow onsplenic gene expression: repercussions for innate and adaptive immunity

摘要

This early postpartum period is also associated with adramatic increase in the rate of liver blood flow and metabo-lism that can compromise liver function and result in produc-tion diseases such as ketosis and fatty liver (30, 73). Fatty livercan affect up to 50% of cows in early lactation (36) and canimpair liver function such as synthesis and biotransformationof metabolites and proteins and the elimination of toxic wasteproducts (6).