Imaging with Semiconductor Quantum Dots

摘要

Multininctional nanoparticle probes bas-ed on semiconductor quantum dots(QDs)have been developed for cancer targeting and imaging in living animals.The struc-tural design involves encapsulating lumi-nescent QDs with an ABC triblock copoly-mer and linking this amphiphilic polymer to tumour-targeting ligands and drug-de-livery functionalities.In vivo targeting stu-dies of human prostate cancer growing in nude mice indicate that the QD probes ac-cumulate at tumours both by the en-hanced permeability and retention of tumour sites and by antibody binding to can-cer-specific cell surface biomarkers.