(3R,8R)-5-hydro-3,8-diethyl-1,6-dioxa-4,9-diaza-5-phosphaspiro[4.4]nonane. Synthesis, structural and spectroscopic properties

摘要

(3R, 8R)-5-Hydro-3,8-diethyl-1,6-dioxa-4,9-diaza-5-spiro [4.4]nonane (1) was prepared by the reaction of (R)-2-aminobutanol-1 with P(Et-2)(3). A mixture of diastereoisomers with different phosphorus center configurations was obtained. Compound 1 was studied by the following set of methods: NMR P-31, C-13, N-15, IR spectroscopy, mass-spectrometry, ultra-centrifugation and single crystal X-ray diffraction analysis. The phosphorus atom is a slightly distorted trigonal bipyramid with the two oxygen atoms in apical positions and the nitrogen atoms in equatorial positions. [References: 13]