Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue

摘要

Objective: To evaluate the efficacy and safety of intralesional injection of pingyangmycin for the treatment of microcystic lymphatic malformations (LMs) in the tongue. Methods: Eighteen patients with tongue microcystic LMs were treated with intralesional injection of pingyangmycin. The concentration of the drug was 1 mg/mL with an addition of dexamethasone. Repeated injections were performed at an interval of 3-4 weeks. The results were evaluated by clinical examinations and Doppler ultrasonography scan. The follow-up period was 12 months to eight years after the last treatment and the mean follow-up time was three years. All patients received 1-8 injections (mean, 3.0 injections) for the whole course of treatment. The total dose of pingyangmycin administered was 8-64 mg (mean, 24 mg). Results: Fifteen patients had complete response with no cosmetic or functional problems. Three patients with macroglossia had a reduction of 50-90% in the lesion size and needed secondary surgery. No serious complications were encountered. Conclusion: The results suggested that intralesional injection of pingyangmycin is an effective and safe treatment for microcystic LMs in the tongue, and can be used as the first-line treatment protocol.