Advantages of organophosphorus synthesis in ionic liquids: 'Green' approaches to useful phosphorus-substituted building blocks

摘要

Novel examples concerning the application of ionic liquids as a promoting reaction media in organophosphorus chemistry are discussed. Imidazolium ionic liquids were found to accelerate the Michaelis-Arbuzov reaction allowing to perform it under very mild conditions. Both phosphonium and imidazolium ILs give the possibility to perform easily direct amidation of phosphotyl acetic acids by various amines. Nucleophilic displacement reaction in a series of bromoalkylphosphonates was carried out in quantitative yield to afford azidoalkylphosphonates using the [bmim][PF6]/H2O system.