Synthesis, anti-HIV, and antifungal activity of new benzensulfonamides bearing the 2,5-disubstituted-1,3,4-oxadiazole moiety

摘要

A series of novel chiral and achiral N-[1-(1,3,4-oxadiazol-2ylthio)alkyll-4-methyl/chloro/methoxybenzenesulfonamides 5a-l were prepared by the reaction of 4-(4-methyl, chloro, methoxyphenylsulfonamido)alkyl carboxylic acid hydrazides 4a-l with CS2 and KOH. Another series of new secondary benzenesulfonamides 10a-j and bis-benzenesulfonamides 11a-j have been synthesized by a new approach using Et3N and dimethylaminopyridine. All synthesized compounds were characterized by physical, microanalytical, and spectral data. Some of the synthesized compounds were screened in vitro for their anti-HIV and antifungal activities.