Synthesis of Certain 2'-Deoxy-3',5'-di-O-benzyl-4'-thio_nucleosides Using Natural Phosphate Doped with Trifluoromethanesulfonic Acid as Catalyst

O. Moukha-Chafiq; J. A. Secrist III; H. B. Lazrek

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Synthesis of Certain 2'-Deoxy-3',5'-di-O-benzyl-4'-thio_nucleosides Using Natural Phosphate Doped with Trifluoromethanesulfonic Acid as Catalyst

机译：以三氟甲磺酸为催化剂的天然磷酸盐合成某些2'-脱氧-3'，5'-二-O-苄基-4'-硫代核苷

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A series of 2'-deoxy-4'-thionucleosides are synthesized by coupling 1-O-acetyl-2 deoxy-3,5-di-O-benzyl-4-thio-D-erythro-pentufuranose to trimethylsilylated nucleobases using natural phosphate doped with trifluoromethanesulfonic acid as catalyst. The detail of this one-pot method and the comparison between the percentage of a and β-2'-deoxy-4'-thionucleosides with those described previously are also reported.

机译：通过使用天然磷酸酯将1-O-乙酰基-2脱氧-3,5-二-O-苄基-4-硫代-D-赤型-戊呋喃糖偶联到三甲基甲硅烷基化的碱基上来合成一系列2'-脱氧-4'-硫代核苷掺杂有三氟甲磺酸作为催化剂。还报道了这种一锅法的细节以及α和β-2'-脱氧-4'-硫代核苷的百分比与先前描述的那些之间的比较。

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《Phosphorus, Sulfur, and Silicon and the Related Elements》 |2009年第1期|共6页
作者
O. Moukha-Chafiq; J. A. Secrist III; H. B. Lazrek;
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原文格式 PDF
正文语种 eng
中图分类 543C0053;
关键词
2'-Deoxy-3'; 5'-di-O-benzyl-4'-thionucleosides; natural phosphate; trifluo_romethanesulfonic acid;

机译：2'-脱氧-3';5'-二-O-苄基-4'-硫代核苷;天然磷酸酯;三氟甲烷磺酸;

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1. Synthesis of Certain 2'-Deoxy-3',5'-di-O-benzyl-4'-thio_nucleosides Using Natural Phosphate Doped with Trifluoromethanesulfonic Acid as Catalyst [J] . O. Moukha-Chafiq, J. A. Secrist III, H. B. Lazrek Phosphorus, Sulfur, and Silicon and the Related Elements . 2009,第1期

机译：以三氟甲磺酸为催化剂的天然磷酸盐合成某些2'-脱氧-3'，5'-二-O-苄基-4'-硫代核苷
2. Building blocks for polyamide nucleic acids: facile synthesis using potassium fluoride doped natural phosphate as basic catalyst. [J] . Alahiane A, Taourirte M, Rochdi A, Nucleosides, nucleotides and nucleic acids . 2003,第2期

机译：聚酰胺核酸的基本组成部分：使用氟化钾掺杂的天然磷酸盐作为碱性催化剂的简便合成。
3. One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst. [J] . Lazrek HB, Baddi L, Smietana M, Nucleosides, nucleotides and nucleic acids . 2008,第10a11期

机译：使用掺杂的天然磷酸盐作为路易斯酸催化剂，一锅法合成抗病毒药阿昔洛韦和其他核苷衍生物。
4. Mutants of Phenylalanine Dehydrogenase: New Bio-Catalysts in the Asymmetric Synthesis and Racemic Resolution of Non-Natural Amino Acids [C] . Eamonn Moynihan, Francesca Paradisi, Paul C. Engel International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

机译：苯丙氨酸脱氢酶的突变体：非天然氨基酸的不对称合成和外消旋分辨率的新生物催化剂
5. Enzymes as catalysts for organic synthesis: Kinetic resolution of unnatural amino acids and alpha-chiral carboxylic acids using acylase I and in situ regeneration of NAD from NADH using lactate dehydrogenase [D] . Chenault, Henry Keith 1989

机译：酶作为有机合成的催化剂：使用酰基转移酶I动力学分解非天然氨基酸和α-手性羧酸，使用乳酸脱氢酶从NADH原位再生NAD
6. Synthesis of P- and N-doped carbon catalysts for the oxygen reduction reaction via controlled phosphoric acid treatment of folic acid [O] . Rieko Kobayashi, Takafumi Ishii, Yasuo Imashiro, 2019

机译：通过叶酸的受控磷酸处理合成用于氧还原反应的P和N掺杂碳催化剂
7. Acidity and reactivity of trifluoromethanesulfonic acid in liquid and solid acid catalysts [O] . MARZIANO N.C, RONCHIN L., TORTATO C, 2001

机译：液体和固体酸催化剂中三氟甲磺酸的酸度和反应性
8. Zirconium-titanium phosphate acid catalysts synthesized by sol gel techniques. [R] . Jackson, N. B., Thoma, S. G., Kohler, S., 1998

机译：溶胶 - 凝胶技术合成的锆 - 钛磷酸催化剂。

Synthesis of Certain 2'-Deoxy-3',5'-di-O-benzyl-4'-thio_nucleosides Using Natural Phosphate Doped with Trifluoromethanesulfonic Acid as Catalyst

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