Aminophosphinic Acids in a Pyridine Series, Part 2: Synthesis of 2-, 3-, and 4-Pyridyl Derivatives of 1-(Benzylamino)-methyl-H-phosphinic Acids

摘要

New 2-pyridyl, 3-pyridyl, and 4-pyridyl derivatives of 1-[N-(benzyl)amino]-methyl-H-phosphinic acid were prepared by the addition of bis(trimethylsilyl)phosphonite to the corresponding imines and subsequent methanolysis of the addition products. Treatment of the 2-pyridyl- and 1-(4-pyridyl)-1-(benzylamino)-methyl-Hphosphinic acids with aqueous mineral acids leads to cleavage and formation of the corresponding secondary amines and phosphorous acid (H_3PO_3).